Phenolic substrates and suicide inactivation of tyrosinase: Kinetics and mechanism

Biochemical Journal

Volumn 416, Issue 3, 2008, Pages 431-440

  Muñoz Muñoz, Jose L ^a   García Molina, Francisco ^a   García Ruiz, Pedro A ^a   Molina Alarcón, Milagros ^b   Tudela, Jose ^a   García Cánovas, Francisco ^a   Rodríguez López, Jose N ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

Deprotonation; Diaxial; Equatorial; Mechanism based inhibitor; Mushroom tyrosinase; Suicide inactivation

Indexed keywords

ANALYTICAL EXPRESSIONS; COPLANARITY; COPPER ATOMS; DIAXIAL; DIPHENOL; ENZYMATIC REACTION; EQUATORIAL; GENERAL BASE; HYDROPHOBIC EFFECT; HYDROXYL GROUPS; KINETIC ANALYSIS; KINETICS AND MECHANISM; MUSHROOM TYROSINASE; NUCLEOPHILIC ATTACK; ORDER OF MAGNITUDE; PHENOLIC SUBSTRATES; PROTONATED; SUICIDE INACTIVATION; THREE ORDERS OF MAGNITUDE; TRANSITION PHASE;

ATOMS; CHEMICAL ATTACK; COMPLEXATION; HYDROGEN; HYDROGEN PEROXIDE; HYDROPHOBICITY; OXIDATION; OXYGEN; PHASE TRANSITIONS; PHENOLS; PROTON TRANSFER; PROTONS; RATE CONSTANTS; SUBSTRATES;

COPPER;

CARBON; COPPER; HYDROXYL GROUP; MONOPHENOL MONOOXYGENASE; PEROXIDE; PHENOL DERIVATIVE; QUINONE DERIVATIVE; ANTIOXIDANT; FUNGAL PROTEIN; PYROGALLOL;

ARTICLE; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME KINETICS; EXPERIMENTAL DESIGN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; AGARICALES; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; NUCLEAR MAGNETIC RESONANCE;

BASIDIOMYCOTA;

AGARICALES; ANTIOXIDANTS; FUNGAL PROTEINS; MOLECULAR STRUCTURE; MONOPHENOL MONOOXYGENASE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; PHENOLS; PYROGALLOL; QUINONES; SUBSTRATE SPECIFICITY;

EID: 58949103292     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20080892     Document Type: Article

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