The effect of the JAK inhibitor CP-690,550 on peripheral immune parameters in stable kidney allograft patients

Transplantation

Volumn 87, Issue 1, 2009, Pages 79-86

  Van Gurp, Evelien A F J ^a   Schoordijk Verschoor, Wenda ^a   Klepper, Mariska ^a   Korevaar, Sander S ^a   Chan, Gary ^b   Weimar, Willem ^a   Baan, Carla C ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b PFIZER INC   (United States)

Author keywords

Biomarkers; JAK3; Kidney transplant patients; New immunosuppression

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; ANTIBIOTIC AGENT; GAMMA INTERFERON; HEMOGLOBIN; INTERLEUKIN 2; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; INTERLEUKIN 2 RECEPTOR ALPHA; JANUS KINASE 3; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ADULT; ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIZZINESS; DRUG EFFECT; FEMALE; GASTROINTESTINAL REFLUX; GENE EXPRESSION; HERPES SIMPLEX; HUMAN; HUMAN CELL; IN VITRO STUDY; INSOMNIA; KIDNEY ALLOGRAFT; LEUKOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; NATURAL KILLER T CELL; NIGHTMARE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SIDE EFFECT; URINARY TRACT INFECTION; ALLOTRANSPLANTATION; BIOSYNTHESIS; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; HEALTH; IMMUNE SYSTEM; IMMUNOLOGY; KIDNEY TRANSPLANTATION; METABOLISM; MIDDLE AGED; T LYMPHOCYTE;

CELL PROLIFERATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HEALTH; HUMANS; IMMUNE SYSTEM; INTERFERON-GAMMA; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; JANUS KINASE 3; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PROTEIN KINASE INHIBITORS; PYRIMIDINES; PYRROLES; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 58949099253     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31818bbea7     Document Type: Article

References (18)

1. Halloran PF. Drug therapy: Immunosuppressive drugs for kidney transplantation. N Eng J Med 2004; 351: 2715.
2. Behbod F, Erwin-Cohen RA, Wang Me, et al. Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways syner-gistically prolongs the survival of rat heart allografts. J Immunol 2001; 166: 3724.
3. Changelian PS, Flamagan ME, Ball DJ, et al. Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 2003; 302: 875.
4. Kudlacz E, Perry B, Sawyer P, et al. The novel JAK-3 inhibitor CP-690,550 is a potent immunosuppressive agent in various murine models. Am J Transplant 2004; 4: 51.
5. Borie DC, Changelian PS, Larson MJ, et al. Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates. Transplantation 2005; 79: 791.
6. bright+ regulatory T cells can mediate donor nonreactivity in long-term immunosup-pressed kidney allograft patients. Am J Transplant 2006; 6: 2955.
7. van der Mast BJ, Rischen-Vos J, de Kuiper P, et al. Calcineurin inhibitor withdrawal in stable kidney transplant patients decreases the donor-specific cytotoxic T lymphocyte precursor frequency. Transplantation 2005; 80: 1220.
8. high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245.
9. Baan CC, van der Mast BJ, Klepper M, et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 2005; 80: 110.
10. Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assay. J Mol Endo 2000; 25: 169.
11. Shuai K, Liu B. Regulation of JAK-STAT signaling in the immune system. Nat Rev Immunol 2003; 3: 900.
12. O'Shea JJ, Husa M, Li D, et al. JAK3 and the pathogenesis of severe combined immunodeficiency. Mol Immunol 2004; 41: 727.
13. Yoa Z, Cui Y, Watford WT, et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc Nat Acad Sci USA 2006; 103: 1000.
14. Paniagua R, Si MS, Flores MG, et al. Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in non-human primate recipients of kidney allografts. Transplantation 2006; 80: 1283.
15. D' Cruz LM, Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 2005; 6: 1152.
16. Brown MP, Nosaka T, Tripp RA, et al. Reconstitution of early lymphoid proliferation and immune function in Jak3 deficient mice by interleukin-3. Blood 1999; 94: 1906.
17. McDyer JF, Li Z, John S, et al. IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: Disruption of both IL-12-dependent and-independent pathways of IFN-gamma production. J Immunol 2002; 169: 2736.
18. Bream JH, Hodge DL, Gonsky R, et al. A distal region in the interferon-γ gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. J Biol Chem 2004; 279: 41249.