Doxorubicin-transferrin conjugate selectively overcomes multidrug resistance in leukaemia cells

Cellular and Molecular Biology Letters

Volumn 14, Issue 1, 2009, Pages 113-127

  Łubgan, Dorota ^a   Jóźwiak, Zofia ^b   Grabenbauer, Gerhard G ^a   Distel, Luitpold V R ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF LODZ   (Poland)

Author keywords

Apoptosis; DNA double strand breaks; Doxorubicin transferrin; Multidrug resistance; Promyelocytic leukaemia

Indexed keywords

DOUBLE STRANDED DNA; DOXORUBICIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG MECHANISM; HUMAN; HUMAN CELL; IC 50; MULTIDRUG RESISTANCE; PROMYELOCYTIC LEUKEMIA; CELL NUCLEUS; CELL STRAIN HL 60; CELL SURVIVAL; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; IMMUNOHISTOCHEMISTRY; LEUKEMIA; METABOLISM; NICK END LABELING; PATHOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS;

APOPTOSIS; CELL NUCLEUS; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HL-60 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INHIBITORY CONCENTRATION 50; LEUKEMIA; RECEPTORS, TRANSFERRIN; TRANSFERRIN;

EID: 58949093276     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-008-0037-2     Document Type: Article

References (31)

1. Gewirtz, D.A. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol. 57 (1999) 727-741.
2. Singal, P.K., Iliskovic, N., Li, T. and Kumar, D. Adriamycin cardiomyopathy: pathophysiology and prevention. FASEB J. 11 (1997) 931-936.
3. Lage, H. ABC-transporters: implications on drug resistance from microorganisms to human cancers. Int. J. Antimicrob. Agents 22 (2003) 188-199. (Pubitemid 37103199)
4. Li, H. and Qian, Z.M. Transferrin/transferrin receptor-mediated drug delivery. Med. Res. Rev. 22 (2002) 225-250.
5. Hatano, T., Ohkawa, K. and Matsuda, M. Cytotoxic effect of the proteindoxorubicin conjugates on the multidrug-resistant human myelogenous leukemia cell line, K562, in vitro. Tumour Biol. 14 (1993) 288-294. (Pubitemid 23357717)
6. Kratz, F., Beyer, U., Roth, T., Tarasova, N., Collery, P., Lechenault, F., Cazabat, A., Schumacher, P., Unger, C. and Falken, U. Transferrin conjugates of doxorubicin: synthesis, characterization, cellular uptake, and in vitro efficacy. J. Pharm. Sci. 87 (1998) 338-346. (Pubitemid 28204588)
7. Daniels, T.R., Delgado, T., Rodriguez, J.A., Helguera, G. and Penichet, M.L. The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin. Immunol. 121 (2006) 144-158. (Pubitemid 44592578)
8. Singh, M. Transferrin as a targeting ligand for liposomes and anticancer drugs. Curr. Pharm. Des. 5 (1999) 443-451. (Pubitemid 29319188)
9. Wang, F., Jiang, X., Yang, D.C., Elliott, R.L. and Head, J.F. Doxorubicingallium- transferrin conjugate overcomes multidrug resistance: evidence for drug accumulation in the nucleus of drug resistant MCF-7/ADR cells. Anticancer Res. 20 (2000) 799-808. (Pubitemid 30240636)
10. Singh, M., Atwal, H. and Micetich, R. Transferrin directed delivery of adriamycin to human cells. Anticancer Res. 18 (1998) 1423-1427. (Pubitemid 28342540)
11. Berczi, A., Barabas, K., Sizensky, J.A. and Faulk, W.P. Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells. Arch. Biochem. Biophys. 300 (1993) 356-363. (Pubitemid 23225757)
12. Sun, I.L., Sun, E.E., Crane, F.L., Morre, D.J. and Faulk, W.P. Inhibition of transplasma membrane electron transport by transferrin-adriamycin conjugates. Biochim. Biophys. Acta 1105 (1992) 84-88.
13. Kobayashi, T., Ishida, T., Okada, Y., Ise, S., Harashima, H. and Kiwada, H. Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells. Int. J. Pharm. 329 (2007) 94-102. (Pubitemid 44937528)
14. Fritzer, M., Szekeres, T., Szuts, V., Jarayam, H.N. and Goldenberg, H. Cytotoxic effects of a doxorubicin-transferrin conjugate in multidrugresistant KB cells. Biochem. Pharmacol. 51 (1996) 489-493. (Pubitemid 26072568)
15. Gallagher, R., Collins, S., Trujillo, J., McCredie, K., Ahearn, M., Tsai, S., Metzgar, R., Aulakh, G., Ting, R., Ruscetti, F. and Gallo, R. Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia. Blood 54 (1979) 713-733. (Pubitemid 10227870)
16. Krishnamachary, N. and Center, M.S. The MRP gene associated with a non- P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer. Res. 53 (1993) 3658-3661. (Pubitemid 23252019)
17. Laemmli, U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685.
18. Wistop, A., Keller, U., Sprung, C.N., Grabenbauer, G.G., Sauer, R. and Distel, L.V. Individual radiosensitivity does not correlate with radiationinduced apoptosis in lymphoblastoid cell lines or CD3+ lymphocytes. Strahlenther. Onkol. 181 (2005) 326-335. (Pubitemid 40768423)
19. Lubgan, D., Distel, L., Grabenbauer, G., Jozwiak, Z. and Sauer, R. Kopplung von Doxorubicin an Transferrin ermöglicht erhöhte Wirkspiegel in multidrug-resistenten Zellen zu erreichen. Strahlenther. Onkol. 181 (2005) 95.
20. Lubgan, D., Distel, L., Grabenbauer, G.G. and Sauer, R. Selektive Therapie von Tumorzellen durch Kopplung von Doxorubicin an Transferrin. Strahlenther. Onkol. 180 (2004) 7.
21. Bryszewska, M., Piasecka, A., Zavodnik, L.B., Distel, L. and Schussler, H. Oxidative damage of Chinese hamster fibroblasts induced by t-butyl hydroperoxide and by X-rays. Biochim. Biophys. Acta 1621 (2003) 285-291. (Pubitemid 36638582)
22. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63. (Pubitemid 14203433)
23. Binaschi, M., Bigioni, M., Cipollone, A., Rossi, C., Goso, C., Maggi, C.A., Capranico, G. and Animati, F. Anthracyclines: selected new developments. Curr. Med. Chem. Anti-Canc. Agents 1 (2001) 113-130.
24. Ward, J.H., Kushner, J.P. and Kaplan, J. Transferrin receptors of human fibroblasts. Analysis of receptor properties and regulation. Biochem. J. 208 (1982) 19-26. (Pubitemid 13215391)
25. Gomme, P.T., McCann, K.B. and Bertolini, J. Transferrin: structure, function and potential therapeutic actions. Drug. Discov. Today 10 (2005) 267-273. (Pubitemid 40222220)
26. Berczi, A., Ruthner, M., Szuts, V., Fritzer, M., Schweinzer, E. and Goldenberg, H. Influence of conjugation of doxorubicin to transferrin on the iron uptake by K562 cells via receptor-mediated endocytosis. Eur. J. Biochem. 213 (1993) 427-436. (Pubitemid 23106074)
27. Daniels, T.R., Delgado, T., Helguera, G. and Penichet, M.L. The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clin. Immunol. 121 (2006) 159-176. (Pubitemid 44572972)
28. Barabas, K., Sizensky, J.A. and Faulk, W.P. Transferrin conjugates of adriamycin are cytotoxic without intercalating nuclear DNA. J. Biol. Chem. 267 (1992) 9437-9442.
29. Inoue, T., Cavanaugh, P.G., Steck, P.A., Brunner, N. and Nicolson, G.L. Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials. J. Cell. Physiol. 156 (1993) 212-217. (Pubitemid 23981332)
30. Buchholz, T.A., Davis, D.W., McConkey, D.J., Symmans, W.F., Valero, V., Jhingran, A., Tucker, S.L., Pusztai, L., Cristofanilli, M., Esteva, F.J., Hortobagyi, G.N. and Sahin, A.A. Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy. Cancer. J. 9 (2003) 33-41.
31. Sizensky, J.A., Barabas, K. and Faulk, W.P. Characterization of the anticancer activity of transferrin-adriamycin conjugates. Am. J. Reprod. Immunol. 27 (1992) 163-166.