Transferrin directed delivery of adriamycin to human cells

Anticancer Research

Volumn 18, Issue 3 A, 1998, Pages 1423-1427

  Singh, Mandip ^a   Atwal, Harninder ^b   Micetich, Ronald ^b  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b SynPhar Laboratories   (Canada)

Author keywords

Adriamycin; Conjugate; Drug resistance; Transferrin

Indexed keywords

DOXORUBICIN; SCHIFF BASE; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CONJUGATION; DRUG RECEPTOR BINDING; DRUG RESISTANCE; DRUG TARGETING; HEP 2 CELL; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MESOTHELIOMA; MOUSE; NONHUMAN; NUDE MOUSE; PERITONEAL CAVITY; PRIORITY JOURNAL; TUMOR CELL LINE;

ANIMALS; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG RESISTANCE, NEOPLASM; HL-60 CELLS; HUMANS; MESOTHELIOMA; MICE; MICE, NUDE; TRANSFERRIN; TUMOR CELLS, CULTURED;

EID: 0031830132     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Robbins E, ederson T: Its ntracellular localizations and possible role in cell division. Proc Natl Acad Sci USA 66: 1244, 1991.
2. Rudland PS, Durbin H, Clingan D, deAusa LJ: Iron salts and trf are specifically required for cell division of cultured 3T6 cells. Biochem Biophys Res Commun 75: 556, 1991.
3. Kohgo Y, Nittsu Y, Nishisato T, Kato J: Extemalization of transferrin receptor in established human cell lines. Cell Biol Int Rep 11: 871-879 1987.
4. Kohgo Y, Niitsu Y, Nishisato T, Urushizaki Y, Kondo H, Fukushima M, Tsushima N, and Urushizaki I: Trf receptors of tumor cells-potential tools for diagnosis and treatment of malignancies. In: Proteins of Iron Storage and Transport ed. G. Spic, J. Momtruil, R.R. Chrichton and J. Mazurier. Elsevier/North-Holland Biomedical Press, Amsterdam., pp: 155-169, 1985.
5. Hopkins CR and Trowbridge IS: Internalization and processing of trf and the transferrin receptor in human carcinoma A431 cell. J Cell Biol 97: 508-521, 1983.
6. Ahmed I, Longnecker M, Samuel J, Allen TM: Antibody-targeted delivery of adr entrapped in sterically stabilized liposomes can eradicate lung cancer in mice. Cancer Res 53: 1484-1488, 1993.
7. Williams S, Alosco TR, Mayhew E, et al: Arrest of human lung tumor xenograft growth in severe combine's immunodeficient mice using adriamycin encapsulated in sterically stabilized liposomes. Cancer Res 53: 3964-3967, 1993.
8. Noda H, Ogasawara T, Lida T, et al: Pharmacodynamics and tumoricidal effect of adriamycin entrapped in ceramide sulfate-containing liposomes. Biol Pharm Bull 17: 1246-1250, 1994.
9. Yang HM, Reisfeld, RA: Adr conjugates with a monoclonal antibody directed to a human melanoma- associated proteoglycan suppresses the growth of established tumor xenografts in nude mice. Proc Natl Acad Sci USA 85: 1189-1193, 1988.
10. Yu D, Chu TM, Yeh M, et al: Antitumor activity of adriamycin-monoclonal antibody conjugate on human bladder cancer. J Urology 140: 415-421, 1988.
11. Trail RA,Willner D, Lasch SJ, Henderson AJ, Hellstrom RA, et al: Cure of xenografted human carcinomas by BR90-doxorubicin immunoconJugates. Science 261: 212-215, 1993.
12. Sizensky JA, Barabas K, Faulk WP: Characterization of the anti-cancer activity of trf-adriamycin conjugates. Am J Reprod Immunol 27: 163-166, 1992.
13. Yeh CG, and Faulk WP: Killing of human tumor cells in culture with adriamycin conjugates of human transferrin. Clin Immunol Immunopathol 32: 1-11, 1984.
14. Barabas K, Sizensky JA, and Faulk WP: Trf conjugates of Adriamycin are cytotoxic without intercalating nuclear DNA. J Biol Chem 267: 9437-9442, 1992.
15. Berczi A, Sizensky JA, Crane F L, and Faulk WP: Diferric transferrin reduction by K562 cells. A crtitical study. Biochim Biophys Acta 1073: 562-570, 1991.
16. Lemieux P, Page M: Sensitivily of multidrug-resistant MCF-7 cells to a transferrin-adriamycin conjugate. Anticancer Res 14: 397-403, 1994.
17. Fritzer M, Barabas K, Szuts V, Berczi and others: Cytotoxicity of a transferrin- adriamycin conjugate to anthracycline-resistant cells. Int J Cancer 52: 619-623, 1992.
18. Griffin TW, Richardson C, LePage D, et al: Antitumor activity of intraperitoneal immunotoxins in a nude mouse model of human malignant mesothelioma. Cancer Res 47: 4266-4282, 1993.
19. Griffin T, Raso V: Monensin in lipid emulsion for the potentiation of ricinA chain immunotoxins. Cancer Res 51: 4316-4322, 1993.
20. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275, 1951.
21. Raso V, McGrath J: Cure of experimental human malignant mesothelioma in athymic mice by diptheria toxin. J Natl Cancer Inst 81: 622-627, 1993.
22. Sun IL, Sun EE, Crane FL, MorreDJ, Faulk WP: Inhibiton of transplasma membrane electron transport by trf-adriamycin conjugates. Biochim Biophys Acta 1105: 84-88, 1992.
23. Fritzer M, Szerkeres T, Szus V, Jarayan H, Goldenberg H: Cytotoxic effects of a Adr Trf conjugate in multidrug-resistant KB cells. Biochemical Pharmacology 51: 489-493, 1992.
24. Ruthner M, Berczi A, and Goldenberg H: interaction of a adr-trf conjugate with isolated trf receptors. Life Sci 54: 35-40, 1994.
25. Hatano T, Ohkawa K, Matsuda M: Cytotoxic effect of the protein-adr conjugates on the multidrug-resistant human myelogenous leukemia cell line, K562, in vitro. Tumor Biol 14: 288-294, 1993.
26. Kohgo Y, Kondo H, Kato J, Saski K, Tsushima N, Nishisato T, Hirayama M, Fujikawa K, Shintani N, Mogi Y, and Niitsu Y: Kinetics of internalization and cytotoxicity of Trf-neocarzinostatin conjugate in human leukemia cell line, K562. Jpn J Cancer Res 81: 91-99, 1990.
27. Martell LA, Agarwal A, Ross DA, Muraszko KM: Efficacy of Trf receptor- targeted immunotoxins in brain tumor cell lines and pediatric brain tumors. Cancer Res 53: 1348-1353, 1993.
28. Kemp JD, Thorson JA, Stewart BC, and Naumann PW: Inhibition of hematopoietic tumor growth by combined treatment with deferoxamine and IgG monoclonal antibody against the Trf receptor: evidence for a threshold model of iron deprivation toxiciry. Cancer Res 52: 4144-4148, 1992.
29. Wagner E, Gotten M, Mechtler K, Kirlappos H, Birnstiel ML: DNA-Binding trf conjugates as a functional gene-delivery agents: synthesis by linkage of polysine or ethidium homodimer to the Trf carbohydrate moiety. Bioconjugate Chem 2: 226-231, 1991.
30. Stavridis JC, Deliconstantinos G, Psallidpopulos MC, Armenakas NA, Hadjiminas DJ, and Hadjiminas J: Construction of Trf-coated liposomes for transport of exogenous DNA to bone marrow erythroblasts in rabbits. Exp Cell Res 164: 558-572, 1986.
31. Faulk WP, Taylor CC, Yeh, CJG and McIntyre JA: Preliminary clinical study of Trf-adriamycin conjugate for drug delivery to acute leukemia patients.Mol Biother 2: 57-60, 1990.