Identification of del(20q) in a subset of patients diagnosed with idiopathic thrombocytopenic purpura

British Journal of Haematology

Volumn 144, Issue 5, 2009, Pages 800-802

  Soupir, Chad P ^a   Vergilio, Jo Anne ^b   Kelly, Eileen ^b   Dal Cin, Paola ^b   Kuter, David ^a   Hasserjian, Robert P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cytogenetics; Fluorescence in situ hybridization; Idiopathic thrombocytopenic purpura; Myelodysplastic syndrome; Thrombocytopenia

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; DANAZOL; GLUCOCORTICOID; HEMOGLOBIN; IMMUNOGLOBULIN; RHESUS D ANTIBODY; RITUXIMAB; ROMIPLOSTIM; VINCRISTINE;

ADULT; AGED; BONE MARROW EXAMINATION; CHROMOSOME 20Q; CHROMOSOME DELETION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; KARYOTYPING; LETTER; LEUKOCYTE COUNT; MALE; PRIORITY JOURNAL; SPLENECTOMY; THROMBOCYTE COUNT; TREATMENT OUTCOME;

ADULT; AGED; CHROMOSOMES, HUMAN, PAIR 20; FEMALE; GENE DELETION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERPHASE; KARYOTYPING; MALE; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; YOUNG ADULT;

EID: 58849153657     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07508.x     Document Type: Letter

References (10)

1. Bizzoni, L., Mazzucconi, M.G., Gentile, M., Santoro, C., Bernasconi, S., Chiarotti, F., Foa, R. Mandelli, F. (2006) Idiopathic thrombocytopenic purpura (ITP) in the elderly: clinical course in 178 patients. European Journal of Haematology, 76, 210 216.
2. Cooper, N. Bussel, J. (2006) The pathogenesis of immune thrombocytopenic purpura. British Journal of Haematology, 133, 364 374.
3. George, J.N., Woolf, S.H., Raskob, G.E., Wasser, J.S., Aledort, L.M., Ballem, P.J., Blanchette, V.S., Bussel, J.B., Cines, D.B., Kelton, J.G., Lichtin, A.E., McMillan, R., Okerbloom, J.A., Regan, D.H. Warrier, I. (1996) Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood, 88, 3 40.
4. Gupta, R., Soupir, C.P., Johari, V. Hasserjian, R.P. (2007) Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation. British Journal of Haematology, 139, 265 268.
5. Han, J.Y. Theil, K.S. (2007) Karyotypic identification of abnormal clones preceding morphological changes or occurring with no definite morphological features of myelodysplastic syndrome: a preliminary study. Laboratory Hematology, 13, 17 21.
6. Kurtin, P.J., Dewald, G.W., Shields, D.J. Hanson, C.A. (1996) Hematologic disorders associated with deletions of chromosome 20q: a clinicopathologic study of 107 patients. American Journal of Clinical Pathology, 106, 680 688.
7. Menke, D.M., Colon-Otero, G., Cockerill, K.J., Jenkins, R.B., Noel, P. Pierre, R.V. (1992) Refractory thrombocytopenia. A myelodysplastic syndrome that may mimic immune thrombocytopenic purpura. American Journal of Clinical Pathology, 98, 502 510.
8. Orazi, A., Brunning, R.D., Baumann, I. Hasserjian, R.P. (2008) Myelodysplastic syndrome, unclassifiable. In : WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (ed. by S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein, J. Thiele J.W. Vardiman p. 103. IARC, Lyon.
9. Sashida, G., Takaku, T.I., Shoji, N., Nishimaki, J., Ito, Y., Miyazawa, K., Kimura, Y., Ohyashiki, J.H. Ohyashiki, K. (2003) Clinico-hematologic features of myelodysplastic syndrome presenting as isolated thrombocytopenia: an entity with a relatively favorable prognosis. Leukaemia & Lymphoma, 44, 653 658.
10. Steensma, D.P., Dewald, G.W., Hodnefield, J.M., Tefferi, A. Hanson, C.A. (2003) Clonal cytogenetic abnormalities in bone marrow specimens without clear morphologic evidence of dysplasia: a form fruste of myelodysplasia? Leukemia Research, 27, 235 242.