S-ethyl-N,N-dipropylthiocarbamate exposure and cancer incidence among male pesticide applicators in the agricultural health study: A prospective cohort

Environmental Health Perspectives

Volumn 116, Issue 11, 2008, Pages 1541-1546

  van Bemmel, Dana M ^a   Visvanathan, Kala ^b   Beane Freeman, Laura E ^a   Coble, Joseph ^a   Hoppin, Jane A ^c   Alavanja, Michael C R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Agriculture; Cancer; EPTC; Herbicide; Neoplasms; Occupational exposure; Pesticides; Thiocarbamates

Indexed keywords

BUTYLATE; DICAMBA; ETHYL N,N DIPROPYLTHIOCARBAMATE; METRIBUZIN; PESTICIDE; TRIFLURALIN; UNCLASSIFIED DRUG; EPTC; HERBICIDE; THIOCARBAMIC ACID DERIVATIVE;

ADULT; AGED; AGRICULTURAL WORKER; ARTICLE; BLADDER CANCER; CANCER INCIDENCE; CANCER RISK; CHEMICAL CARCINOGENESIS; COHORT ANALYSIS; COLON CANCER; CONTROLLED STUDY; FOLLOW UP; HUMAN; LEUKEMIA; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; NONHODGKIN LYMPHOMA; OCCUPATIONAL CANCER; OCCUPATIONAL CARCINOGENESIS; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; PESTICIDE SPRAYING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CANCER; RECTUM CANCER; CHEMICALLY INDUCED DISORDER; INCIDENCE; MIDDLE AGED; NEOPLASM; OCCUPATIONAL DISEASE; UNITED STATES;

ADULT; AGRICULTURAL WORKERS' DISEASES; COHORT STUDIES; HERBICIDES; HUMANS; INCIDENCE; IOWA; MALE; MIDDLE AGED; NEOPLASMS; NORTH CAROLINA; THIOCARBAMATES;

EID: 58849153656     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11371     Document Type: Article

References (42)

1. Abu-Qare AW, Duncan HJ. 2002. Photodegradation of the herbicide EPTC and the safener dichlormid, alone and in combination. Chemosphere 46(8):1183-1189.
2. Acquavella JF, Alexander BH, Mandel JS, Burns CJ, Gustin 2006. Exposure misclassification in studies of agricultural pesticides: insights from biomonitoring. Epidemiology 17(1):69-74.
3. Acquavella JF, Delzell E, Cheng H, Lynch CF, Johnson G. 2004. Mortality and cancer incidence among alachlor manufacturing workers 1968-99. Occup Environ Med 61(8):680-685.
4. Acquavella JF, Riordan SG, Anne M, Lynch CF, Collins JJ, Ireland BK, et al. 1996. Evaluation of mortality and cancer incidence among alachlor manufacturing workers. Environ Health Perspect 104:728-733.
5. Alavanja MC, Samanic C, Dosemeci M, Lubin J, Tarone R, Lynch CF, et al. 2003. Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol 157(9):800-814.
6. Alavanja MC, Sandler DP, Lynch CF, Knott C, Lubin JH, Tarone R, et al. 2005. Cancer incidence in the agricultural health study. Scand J Work Environ Health 31(suppl 1):39-45.
7. Alavanja MC, Sandler DP, McMaster SB, Zahm SH, McDonnell CJ, Lynch CF, et al. 1996. The Agricultural Health Study. Environ Health Perspect 104:362-369.
8. Beane Freeman LE, Bonner MR, Blair A, Hoppin JA, Sandler DP, Lubin JH, et al. 2005. Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon. Am J Epidemiol 162(11):1070-1079.
9. Blair A, Tarone R, Sandler D, Lynch CF, Rowland A, Wintersteen W, et al. 2002. Reliability of reporting on lifestyle and agricultural factors by a sample of participants in the Agricultural Health Study from Iowa. Epidemiology 13(1):94-99.
10. Blair A, Zahm SH. 1991. Cancer among farmers. Occup Med 6(3):335-354.
11. Brown LM, Blair A, Gibson R, Everett GD, Cantor KP, Schuman LM, et al. 1990. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Res 50(20):6585-6591.
12. Calderon-Segura ME, Gomez-Arroyo S, Molina-Alvarez B, Villalobos-Pietrini R, Calderon-Ezquerro C, Cortes-Eslava J, et al. 2007. Metabolic activation of herbicide products by Vicia faba detected in human peripheral lymphocytes using alkaline single cell gel electrophoresis. Toxicol In Vitro 21(6):1143-1154.
13. Calderon-Segura ME, Gomez-Arroyo S, Villalobos-Pietrini R, Espinosa-Ramirez M. 1999. In vivo and in vitro promutagen activation by Vicia faba of thiocarbamate herbicides molinate and butylate to products inducing sister chromatid exchanges in human lymphocyte cultures. Mutat Res 438(2):81-88.
14. Cantor KP, Blair A, Everett G, Gibson R, Burmeister LF, Brown LM, et al. 1992. Pesticides and other agricultural risk factors for non-Hodgkin's lymphoma among men in Iowa and Minnesota. Cancer Res 52(9):2447-2455.
15. Chen YS, Casida JE. 1978. Thiocarbamate herbicide metabolism: microsomal oxygenase metabolism of EPTC involving mono- and dioxygenation at the sulfur and hydroxylation at each alkyl carbon. J Agric Food Chem 26(1):263-267.
16. Coble J, Arbuckle T, Lee W, Alavanja M, Dosemeci M. 2005. The validation of a pesticide exposure algorithm using biological monitoring results. J Occup Environ Hyg 2(3):194-201.
17. De Roos AJ, Zahm SH, Cantor KP, Weisenburger DD, Holmes FF, Burmeister LF, et al. 2003. Integrative assessment of multiple pesticides as risk factors for non-Hodgkin's lymphoma among men. Occup Environ Med 60(9):E11.
18. Dickie BC. 1987. Two-year oral feeding study of the oncogenicity and chronic toxicity of EPTC in rats: Hazelton Laboratories America, Inc. PPG Industries, Inc. Study No. 6100-106. DPR Vol. 117-069 No. 55491. Washington, DC:Department of Pesticide Regulation.
19. Dosemeci M, Alavanja MC, Rowland AS, Mage D, Zahm SH, Rothman N, et al. 2002. A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg 46(2):245-260.
20. Forastiere F, Quercia A, Miceli M, Settimi L, Terenzoni B, Rapiti E, et al. 1993. Cancer among farmers in central Italy. Scand J Work Environ Health 19(6):382-389.
21. Georgian L, Moraru I, Draghicescu T, Dinu I, Ghizelea G. 1983. Cytogenetic effects of alachlor and mancozeb. Mutat Res 116(3-4):341-348.
22. Hoppin JA, Yucel F, Dosemeci M, Sandler DP. 2002. Accuracy of self-reported pesticide use duration information from licensed pesticide applicators in the Agricultural Health Study. J Expo Anal Environ Epidemiol 12(5):313-318.
23. Hubbell JP, Casida JE. 1977. Metabolic fate of the N,N-dialkylcarbamoyl moiety of thiocarbamate herbicides in rats and corn. J Agric Food Chem 25(2):404-413.
24. Kawashima K, Fujii T. 2003. The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life Sci 74(6):675-696.
25. Lee WJ, Hoppin JA, Blair A, Lubin JH, Dosemeci M, Sandler DP, et al. 2004. Cancer incidence among pesticide applicators exposed to alachlor in the Agricultural Health Study. Am J Epidemiol 159(4):373-380.
26. Lee WJ, Sandler DP, Blair A, Samanic C, Cross AJ, Alavanja MC. 2007. Pesticide use and colorectal cancer risk in the Agricultural Health Study. Int J Cancer 121(2):339-346.
27. Nagy I, Schoofs G, Compernolle F, Proost P, Vanderleyden J, de Mot R. 1995. Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde dehydrogenase. J Bacteriol 177(3):676-687.
28. National Institutes of Health. 2004. Agricultural Health Study. Available: http://www.aghealth.org [accessed 15 January 2007].
29. Purdue MP, Jarvholm B, Bergdahl IA, Hayes RB, Baris D. 2006. Occupational exposures and head and neck cancers among Swedish construction workers. Scand J Work Environ Health 32(4):270-275.
30. Rusiecki JA, De Roos A, Lee WJ, Dosemeci M, Lubin JH, Hoppin JA, et al. 2004. Cancer incidence among pesticide applicators exposed to atrazine in the Agricultural Health Study. J Natl Cancer Inst 96(18):1375-1382.
31. Samanic C, Rusiecki J, Dosemeci M, Hou L, Hoppin JA, Sandler DP, et al. 2006. Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health study. Environ Health Perspect 114:1521-1526.
32. Smulders CJ, Bueters TJ, Van Kleef RG, Vijverberg HP. 2003. Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. Toxicol Appl Pharmacol 193(2):139-146.
33. Smulders CJ, Van Kleef RG, de Groot A, Gotti C, Vijverberg HP. 2004. A noncompetitive, sequential mechanism for inhibition of rat alpha4beta2 neuronal nicotinic acetylcholine receptors by carbamate pesticides. Toxicol Sci 82(1):219-227.
34. Staub RE, Sparks SE, Quistad GB, Casida JE. 1995. S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors. Chem Res Toxicol 8(8):1063-1069.
35. Tisdel M, Kehoe S, Carter JL, Leber AP. 1986. Oncogenicity study in mice with EPTC: Hazelton Laboratories America, Inc. PPG Industries Inc. Study No. 6100-I 04. DPR Vol. 117-049 No. 45704. Washington, DC:Department of Pesticide Regulation.
36. U.S. EPA. 1999. Prevention, Pesticides, and Toxic Substances EPA-738-F-00-011. Washington, DC:U.S. Environmental Protection Agency.
37. U.S. EPA. 2002. Pesticide Industry Sales and Usage. 1998 and 1999 Market Estimates EPA-733-R-02-001. Washington, DC:Office of Prevention, Pesticides, and Toxic Substances. U.S. EPA. December 2006. Regulatory Determinations Support Documents for Selected Contaminants from the Second Drinking Water Contaminant Candidate List (CCL2) 815-D-06-007. Washington, DC:U.S. Environmental Protection Agency.
38. U.S. Geological Survey. 2004. 1997 Pesticide Use Maps. Reston, VA:U.S. Geological Survey.
39. Waddell BL, Zahm SH, Baris D, Weisenburger DD, Holmes F, Burmeister LF, et al. 2001. Agricultural use of organophosphate pesticides and the risk of non-Hodgkin's lymphoma among male farmers (United States). Cancer Causes Control 12(6):509-517.
40. World Health Organization. 1990. International Classification of Diseases for Oncology. 2nd ed. Geneva:World Health Organization.
41. Zheng T, Zahm SH, Cantor KP, Weisenburger DD, Zhang Y, Blair A. 2001. Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphoma. J Occup Environ Med 43(7):641-649.
42. Zimmerman LJ, Valentine HL, Valentine WM. 2004. Characterization of S-(N,N-dialkylaminocarbonyl)cysteine adducts and enzyme inhibition produced by thiocarbamate herbicides in the rat. Chem Res Toxicol 17(2):258-267.