Discovery of novel 2′,3′,4′-trihydroxy-2- phenylacetophenone derivatives as anti-gram-positive antibacterial agents

Bioscience, Biotechnology and Biochemistry

Volumn 73, Issue 1, 2009, Pages 124-128

  Goto, Hideyuki ^a   Kumada, Yuji ^b   Ashida, Hitoshi ^b   Yoshida, Ken Ichi ^b  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

2 phenylacetophenone; Antibacterial agent; Gram positve; Staphylococcus aureus

Indexed keywords

BACTERIOLOGY; ESCHERICHIA COLI; FUNCTIONAL GROUPS;

2-PHENYLACETOPHENONE; ANTI-BACTERIAL ACTIVITIES; ANTIBACTERIAL AGENT; ANTIBACTERIAL COMPOUNDS; BACILLUS SUBTILIS; GRAM-NEGATIVE STRAINS; GRAM-POSITIVE STRAINS; GRAM-POSITVE; GROWTH INHIBITIONS; INHIBITORY EFFECTS; PHENYL RINGS; PROTEUS MIRABILIS; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA; STAPHYLOCOCCUS AUREUS;

AGENTS;

ACETOPHENONE; ACETOPHENONE DERIVATIVE; ANTIINFECTIVE AGENT;

ARTICLE; BACILLUS SUBTILIS; CHEMISTRY; DRUG EFFECT; GRAM POSITIVE BACTERIUM; MICROBIOLOGICAL EXAMINATION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ACETOPHENONES; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA; PROTEUS MIRABILIS; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA; STAPHYLOCOCCUS AUREUS;

EID: 58849133370     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80532     Document Type: Article

References (11)

1. Bozdogan, B., Ednie, L., Credito, K., Kosowska, K., and Appelbaum, P. C., Derivatives of a vancomycin-resistant Staphylococcus aureus strain isolated at Hershey Medical Center. Antimicrob. Agents Chemother., 48, 4762-4765 (2004).
2. Harthug, S., Digranes, A., Hope, O., Kristiansen, B. E., Allum, A. G., and Langeland, N., Vancomycin resistance emerging in a clonal outbreak caused by ampicillin-resistant Enterococcus faecium. Clin. Microbiol. Infect., 6, 19-28 (2000).
3. Friedman, M., Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Mol. Nutr. Food Res., 51, 116-134 (2007).
4. Emami, S., Foroumadi, A., Faramarzi, M. A., and Samadi, N., Synthesis and antibacterial activity of quinolone-based compounds containing a coumarin moiety. Arch. Pharm., 341, 42-48 (2008).
5. Fokialakis, N., Lambrinidis, G., Mitsiou, D. J., Aligiannis, N., Mitakou, S., Skaltsounis, A. L., Pratsinis, H., Mikros, E., and Alexis, M. N., A new class of phytoestrogens; evaluation of the estrogenic activity of deoxybenzoins. Chem. Biol., 11, 397-406 (2004).
6. Dufresne, C., Roy, P., Wang, Z., Asante-Appiah, E., Cromlish, W., Boie, Y., Forghani, F., Desmarais, S., Wang, Q., Skorey, K., Waddleton, D., Ramachandran, C., Kennedy, B. P., Xu, L., Gordon, R., Chan, C. C., and Leblanc, Y., The development of potent non-peptidic PTP-1B inhibitors. Bioorg. Med. Chem. Lett., 14, 1039-1042 (2004).
7. Li, H. Q., Xue, J. Y., Shi, L., Gui, S. Y., and Zhu, H. L., Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. Eur. J. Med. Chem., 43, 662-667 (2008).
8. Almeida, A. A., Farah, A., Silva, D. A., Nunan, E. A., and Glória, M. B., Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. J. Agric. Food Chem., 54, 8738-8743 (2006).
9. Bernhard, H. P., Darlington, G. J., and Ruddle, F. H., Expression of liver phenotypes in cultured mouse hepatoma cells: synthesis and secretion of serum albumin. Dev. Biol., 35, 83-96 (1973).
10. Chang, Y. C., Nair, M. G., Santell, R. C., and Helferich, W. G., Microwave-mediated synthesis of anticarcinogenic isoflavones from soybeans. J. Agric. Food Chem., 42, 1869-1871 (1994).
11. Lang'at-Thoruwa, C., Kirby, G. C., Phillipson, J. D., Warhurst, D. C., Watt, R. A., and Wright, C. W., Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone. J. Nat. Prod., 66, 1486-1489 (2003).