Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor

Neurochemical Research

Volumn 34, Issue 2, 2009, Pages 311-315

  Taha, Ameer Y ^a   Chen, Chuck T ^a   Liu, Zhen ^a   Kim, John H ^b   Mount, Howard T J ^b   Bazinet, Richard P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Brain; Brainstem; Cholesterol; Cortex; Low density lipoprotein receptor

Indexed keywords

CHLOROFORM; CHLOROTRIMETHYLSILANE; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; METHANOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN STEM; CONTROLLED STUDY; MASS FRAGMENTOGRAPHY; MICROWAVE IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BRAIN STEM; CHOLESTEROL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MICE; MICE, INBRED BALB C; RECEPTORS, LDL;

MUS;

EID: 58849121845     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9777-7     Document Type: Article

References (24)

1. JM Dietschy SD Turley 2004 Thematic review series: brain Lipids Cholesterol metabolism in the central nervous system during early development and in the mature animal J Lipid Res 45 1375 1397 10.1194/jlr.R400004-JLR200
2. H Jurevics P Morell 1995 Cholesterol for synthesis of myelin is made locally, not imported into brain J Neurochem 64 895 901
3. PJ Bennett MA Simmonds 1996 The influence of membrane cholesterol on the GABAA receptor Br J Pharmacol 117 87 92
4. MA Cortez SC Cunnane OC Snead III 2002 Brain sterols in the AY-9944 rat model of atypical absence seizures Epilepsia 43 3 8 10.1046/j.1528-1157.2002. 22401.x
5. I Serbanescu MA Ryan R Shukla MA Cortez OC Snead III SC Cunnane 2004 Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols J Lipid Res 45 2038 2043 10.1194/jlr.M400097-JLR200
6. MK Cooper CA Wassif PA Krakowiak J Taipale R Gong RI Kelley 2003 A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis Nat Genet 33 508 513 10.1038/ng1134
7. PT Kovanen SK Basu JL Goldstein MS Brown 1979 Low density lipoprotein receptors in bovine adrenal cortex II. Low density lipoprotein binding to membranes prepared from fresh tissue Endocrinology 104 610 616
8. PT Kovanen JR Faust MS Brown JL Goldstein 1979 Low density lipoprotein receptors in bovine adrenal cortex I. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells Endocrinology 104 599 609
9. SD Turley DK Burns CR Rosenfeld JM Dietschy 1996 Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep J Lipid Res 37 1953 1961
10. Y Osono LA Woollett J Herz JM Dietschy 1995 Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse J Clin Invest 95 1124 1132 10.1172/JCI117760
11. RJ Webber J Edmond 1979 The in vivo utilization of acetoacetate, d-(-)-3-hydroxybutyrate, and glucose for lipid synthesis in brain in the 18-day-old rat. Evidence for an acetyl-CoA bypass for sterol synthesis J Biol Chem 254 3912 3920
12. SL Hofmann DW Russell JL Goldstein MS Brown 1987 mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits Proc Natl Acad Sci USA 84 6312 6316 10.1073/pnas.84.17.6312
13. ES Lein MJ Hawrylycz N Ao M Ayres A Bensinger A Bernard 2007 Genome-wide atlas of gene expression in the adult mouse brain Nature 445 168 176 10.1038/nature05453
14. CT Chen DW Ma JH Kim HT Mount RP Bazinet 2008 The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations J Lipid Res 49 147 152 10.1194/jlr.M700386-JLR200
15. RP Bazinet HJ Lee CC Felder AC Porter SI Rapoport TA Rosenberger 2005 Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain Neurochem Res 30 597 601 10.1007/s11064-005-2746-5
16. ML Adams DM Sullivan RL Smith EF Richter 1986 Evaluation of direct saponification method for determination of cholesterol in meats J Assoc Off Anal Chem 69 844 846
17. J Edmond RA Korsak JW Morrow G Torok-Both DH Catlin 1991 Dietary cholesterol and the origin of cholesterol in the brain of developing rats J Nutr 121 1323 1330
18. HA Jurevics FZ Kidwai P Morell 1997 Sources of cholesterol during development of the rat fetus and fetal organs J Lipid Res 38 723 733
19. G Quan C Xie JM Dietschy SD Turley 2003 Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse Brain Res Dev Brain Res 146 87 98 10.1016/j.devbrainres.2003.09.015
20. MY Golovko EJ Murphy 2008 An improved LC-MS/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquid-liquid extraction J Lipid Res 49 893 902 10.1194/jlr.D700030-JLR200
21. E Grange J Deutsch QR Smith M Chang SI Rapoport AD Purdon 1995 Specific activity of brain palmitoyl-CoA pool provides rates of incorporation of palmitate in brain phospholipids in awake rats J Neurochem 65 2290 2298
22. GA Elder JY Cho DF English S Franciosi J Schmeidler MA Sosa 2007 Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor J Neurochem 102 1220 1231 10.1111/j.1471-4159.2007.04614.x
23. SL Boleman TL Graf HJ Mersmann DR Su LP Krook JW Savell 1998 Pigs fed cholesterol neonatally have increased cerebrum cholesterol as young adults J Nutr 128 2498 2504
24. WG Pond HJ Mersmann D Su JJ McGlone MB Wheeler EO Smith 2008 Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behavior J Nutr 138 282 286