Antifungal therapy for chronic rhinosinusitis: The controversy persists

Current Opinion in Allergy and Clinical Immunology

Volumn 9, Issue 1, 2009, Pages 67-72

  Rank, Matthew A ^a   Adolphson, Cheryl R ^a   Kita, Hirohito ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC ROCHESTER   (United States)

Author keywords

Amphotericin B; Antifungal; Sinusitis

Indexed keywords

AMPHOTERICIN B; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIHISTAMINIC AGENT; ITRACONAZOLE; PLACEBO; STEROID; TERBINAFINE;

CLINICAL FEATURE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DISEASE CLASSIFICATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MEGADOSE; DRUG STABILITY; HUMAN; IMMUNE RESPONSE; NOSE POLYP; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; RHINOSINUSITIS; TREATMENT OUTCOME;

ANTIFUNGAL AGENTS; CHRONIC DISEASE; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RHINITIS; SINUSITIS; TREATMENT OUTCOME;

EID: 58849119477     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e328320d279     Document Type: Review

References (13)

1. Pleis JR, Coles R. Summary health statistics for US adults: National Health Interview Survey, 1998. National Center for Health Statistics. Vital Health Stat 2002; 10:1-113.
2. Slavin RG, Spector SL, Bernstein IL. The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol 2005; 116: S13-S47.
3. Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 2004; 114:S155-S212.
4. Scadding GK, Durham DR, Mirakian R, et al. BSACI guidelines for the management of rhinosinusitis and nasal polyposis. Clin Exp Allergy 2007; 38:260-275. A recent and concise summary of diagnostic and treatment issues concerning chronic sinusitis and nasal polyps.
5. Guidance for industry. Sinusitis: designing clinical development programs of nonantimicrobial drugs for treatment. U.S. Department of Health and Human Services Food and Drug Administration, November 2006 http://www.fda.gov/cder/ guidance/7316dft.htm. [Accessed 15 May 2008]. An important document that describes key clinical trial components and endpoints specifically related to sinusitis trials.
6. Ponikau JU, Sherris DA, Kern EB, et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 1999; 74:877-884.
7. Shin SH, Ponikau JU, Sherris DA, et al. Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol 2004; 114:1369-1375.
8. www.clinicaltrials.gov [Accessed 15 May 2008].
9. Liang KL, Su MC, Shiao JY, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol 2008; 22:52-58. The most recent controlled amphotericin trial demonstrating some symptom improvement in CRS patients without nasal polyps.
10. Ebbens FA, Scadding GK, Badia L, et al. Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 2006; 118:1149-1156.
11. Ponikau JU, Sherris DA, Weaver A, Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double- blind pilot trial. J Allergy Clin Immunol 2005; 15:125-131.
12. Kennedy DW, Kuhn FA, Hamilos DL, et al. Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope 2005; 115:1793-1799.
13. Weschta M, Rimek D, Fromanek M, et al. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 2004; 113:1122-1128.