CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes

Journal of Autoimmunity

Volumn 32, Issue 1, 2009, Pages 70-77

  Fousteri, Georgia ^a   Dave, Amy ^a   Juntti, Therese ^a   von Herrath, Matthias ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

CD8+ effector memory response; Insulitis; Integrin CD103 ( E 7); LCMV; Type 1 diabetes (T1D)

Indexed keywords

ANTIVIRUS AGENT; CD103 ANTIGEN;

ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; DISEASE SEVERITY; EXPERIMENTAL MOUSE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS MENINGITIS;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, CD8; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; EPITOPES, T-LYMPHOCYTE; FEMALE; INSULIN; INTEGRIN ALPHA CHAINS; INTERFERON-GAMMA; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PANCREAS; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA; VIRAL PROTEINS; VIRUS DISEASES;

EID: 58849109805     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2008.12.001     Document Type: Article

References (41)

1. Andrew D.P., Rott L.S., Kilshaw P.J., and Butcher E.C. Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes. Eur J Immunol 26 (1996) 897-905
2. Cepek K.L., Parker C.M., Madara J.L., and Brenner M.B. Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol 150 (1993) 3459-3470
3. Geiger B., and Ayalon O. Cadherins. Annu Rev Cell Biol 8 (1992) 307-332
4. Kilshaw P.J. Expression of the mucosal T cell integrin alpha M290 beta 7 by a major subpopulation of dendritic cells in mice. Eur J Immunol 23 (1993) 3365-3368
5. Agace W.W., Higgins J.M., Sadasivan B., Brenner M.B., and Parker C.M. T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines. Curr Opin Cell Biol 12 (2000) 563-568
6. Brown D.W., Furness J., Speight P.M., Thomas G.J., Li J., Thornhill M.H., et al. Mechanisms of binding of cutaneous lymphocyte-associated antigen-positive and alphaebeta7-positive lymphocytes to oral and skin keratinocytes. Immunology 98 (1999) 9-15
7. Strauch U.G., Mueller R.C., Li X.Y., Cernadas M., Higgins J.M., Binion D.G., et al. Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction. J Immunol 166 (2001) 3506-3514
8. Smyth L.J., Kirby J.A., and Cunningham A.C. Role of the mucosal integrin alpha(E)(CD103)beta(7) in tissue-restricted cytotoxicity. Clin Exp Immunol 149 (2007) 162-170
9. Le Floc'h A., Jalil A., Vergnon I., Le Maux Chansac B., Lazar V., Bismuth G., et al. Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J Exp Med 204 (2007) 559-570
10. El-Asady R., Yuan R., Liu K., Wang D., Gress R.E., Lucas P.J., et al. TGF-{beta}-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J Exp Med 201 (2005) 1647-1657
11. Izcue A., Coombes J.L., and Powrie F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev 212 (2006) 256-271
12. Lehmann J., Huehn J., de la Rosa M., Maszyna F., Kretschmer U., Krenn V., et al. Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci U S A 99 (2002) 13031-13036
13. Huehn J., Siegmund K., Lehmann J.C., Siewert C., Haubold U., Feuerer M., et al. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 199 (2004) 303-313
14. Annacker O., Coombes J.L., Malmstrom V., Uhlig H.H., Bourne T., Johansson-Lindbom B., et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 202 (2005) 1051-1061
15. Banz A., Peixoto A., Pontoux C., Cordier C., Rocha B., and Papiernik M. A unique subpopulation of CD4+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis. Eur J Immunol 33 (2003) 2419-2428
16. Suffia I., Reckling S.K., Salay G., and Belkaid Y. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J Immunol 174 (2005) 5444-5455
17. Sather B.D., Treuting P., Perdue N., Miazgowicz M., Fontenot J.D., Rudensky A.Y., et al. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 204 (2007) 1335-1347
18. Schon M.P., Schon M., Warren H.B., Donohue J.P., and Parker C.M. Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice. J Immunol 165 (2000) 6583-6589
19. Johansson-Lindbom B., Svensson M., Pabst O., Palmqvist C., Marquez G., Forster R., et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 202 (2005) 1063-1073
20. Schon M.P., Arya A., Murphy E.A., Adams C.M., Strauch U.G., Agace W.W., et al. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol 162 (1999) 6641-6649
21. Jaensson E., Uronen-Hansson H., Pabst O., Eksteen B., Tian J., Coombes J.L., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 205 (2008) 2139-2149
22. Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204 (2007) 1757-1764
23. Hanninen A., Salmi M., Simell O., and Jalkanen S. Mucosa-associated (beta 7-integrinhigh) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior. Diabetes 45 (1996) 1173-1180
24. Yang H., Issekutz T.B., and Wright Jr. J.R. Prolongation of rat islet allograft survival by treatment with monoclonal antibodies against VLA-4 and LFA-1. Transplantation 60 (1995) 71-76
25. Feng Y., Wang D., Yuan R., Parker C.M., Farber D.L., and Hadley G.A. CD103 expression is required for destruction of pancreatic islet allografts by CD8(+) T cells. J Exp Med 196 (2002) 877-886
26. Andreasen S.O., Christensen J.E., Marker O., and Thomsen A.R. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164 (2000) 3689-3697
27. Bachmann M.F., Schwarz K., Wolint P., Meijerink E., Martin S., Manolova V., et al. Cutting edge: distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells. J Immunol 173 (2004) 2217-2221
28. Borrow P., Tishon A., Lee S., Xu J., Grewal I.S., Oldstone M.B., et al. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J Exp Med 183 (1996) 2129-2142
29. Kopf M., Ruedl C., Schmitz N., Gallimore A., Lefrang K., Ecabert B., et al. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity 11 (1999) 699-708
30. Suresh M., Whitmire J.K., Harrington L.E., Larsen C.P., Pearson T.C., Altman J.D., et al. Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J Immunol 167 (2001) 5565-5573
31. von Herrath M.G., Yokoyama M., Dockter J., Oldstone M.B., and Whitton J.L. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J Virol 70 (1996) 1072-1079
32. Hadley G.A., Rostapshova E.A., Gomolka D.M., Taylor B.M., Bartlett S.T., Drachenberg C.I., et al. Regulation of the epithelial cell-specific integrin, CD103, by human CD8+ cytolytic T lymphocytes. Transplantation 67 (1999) 1418-1425
33. Zhao D., Zhang C., Yi T., Lin C.L., Todorov I., Kandeel F., et al. In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease. Blood 112 (2008) 2129-2138
34. Ludviksson B.R., Strober W., Nishikomori R., Hasan S.K., and Ehrhardt R.O. Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice. J Immunol 162 (1999) 4975-4982
35. Andersson E.C., Christensen J.P., Scheynius A., Marker O., and Thomsen A.R. Lymphocytic choriomeningitis virus infection is associated with long-standing perturbation of LFA-1 expression on CD8+ T cells. Scand J Immunol 42 (1995) 110-118
36. Marker O., Scheynius A., Christensen J.P., and Thomsen A.R. Virus-activated T cells regulate expression of adhesion molecules on endothelial cells in sites of infection. J Neuroimmunol 62 (1995) 35-42
37. Lefrancois L., Parker C.M., Olson S., Muller W., Wagner N., Schon M.P., et al. The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response. J Exp Med 189 (1999) 1631-1638
38. Wen L., Ley R.E., Volchkov P.Y., Stranges P.B., Avanesyan L., Stonebraker A.C., et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455 (2008) 1109-1113
39. Homann D., Dyrberg T., Petersen J., Oldstone M.B., and von Herrath M.G. Insulin in oral immune "tolerance": a one-amino acid change in the B chain makes the difference. J Immunol 163 (1999) 1833-1838
40. Ma S., Huang Y., Yin Z., Menassa R., Brandle J.E., and Jevnikar A.M. Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci U S A 101 (2004) 5680-5685
41. Bosco D., Rouiller D.G., and Halban P.A. Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity. J Endocrinol 194 (2007) 21-29