Gastric hypersensitivity induced by oesophageal acid infusion in healthy volunteers

Neurogastroenterology and Motility

Volumn 21, Issue 2, 2009, Pages 160-169

  Van Den Elzen, B D J ^b   Tytgat, G N J ^b   Boeckxstaens, G E E ^a,b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Acid infusion; Barostat; Gastric hypersensitivity; Oesophagus; Visceral hypersensitivity

Indexed keywords

HYDROCHLORIC ACID; SODIUM CHLORIDE;

ADULT; ARTICLE; CONTROLLED STUDY; DUODENUM PH; FEMALE; GASTRIC HYPERSENSITIVITY; HUMAN; HUMAN EXPERIMENT; LOWER ESOPHAGUS SPHINCTER; MALE; PERCEPTION; PRIORITY JOURNAL; SENSORIMOTOR FUNCTION; STOMACH ACID; STOMACH DISEASE;

ACIDS; ADOLESCENT; ADULT; ANIMALS; AREA UNDER CURVE; ESOPHAGUS; FEMALE; GASTROINTESTINAL MOTILITY; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERSENSITIVITY; MALE; PLACEBOS; SENSATION; STOMACH; YOUNG ADULT;

EID: 58849101396     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01172.x     Document Type: Article

References (23)

1. Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology 2002 123 : 2108 31.
2. Stanghellini V, De Ponti F, De Giorgio R, Barbara G, Tosetti C, Corinaldesi R. New developments in the treatment of functional dyspepsia. Drugs 2003 63 : 869 92.
3. Torebjork HE, Lundberg LE, LaMotte RH. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 1992 448 : 765 80.
4. Treede RD, Meyer RA, Raja SN, Campbell JN. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol 1992 38 : 397 421.
5. Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature 1983 306 : 686 8.
6. Garrison DW, Chandler MJ, Foreman RD. Viscerosomatic convergence onto feline spinal neurons from esophagus, heart and somatic fields: effects of inflammation. Pain 1992 49 : 373 82.
7. Sarkar S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000 356 : 1154 9.
8. Talley NJ, Haque M, Wyeth JW et al. Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index. Alimen Pharmacol Ther 1999 13 : 225 35.
9. Lee KJ, Vos R, Janssens J, Tack J. Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans. Am J Physiol Gastrointest Liver Physiol 2004 286 : G278 84.
10. Lu YX, Owyang C. Duodenal acid-induced gastric relaxation is mediated by multiple pathways. Am J Physiol 1999 276 : G1501 6.
11. Holzer P, Painsipp E, Jocic M, Heinemann A. Acid challenge delays gastric pressure adaptation, blocks gastric emptying and stimulates gastric fluid secretion in the rat. Neurogastroenterol Motil 2003 15 : 45 55.
12. Brodal A. Neurological Anatomy in relation to Clinical Medicine, 3rd edn, chapter 11. Oxford : Oxford University Press, 1981 : 773 6.
13. Ozaki N, Gebhart GF. Characterization of mechanosensitive splanchnic nerve afferent fibers innervating the rat stomach. Am J Physiol Gastrointest Liver Physiol 2001 281 : G1449 59.
14. Danzer M, Jocic M, Samberger C et al. Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion. Am J Physiol Gastrointest Liver Physiol 2004 286 : G403 11.
15. Accarino AM, Azpiroz F, Malagelada JR. Attention and distraction: effects on gut perception. Gastroenterology 1997 113 : 415 22.
16. Accarino AM, Azpiroz F, Malagelada JR. Modification of small bowel mechanosensitivity by intestinal fat. Gut 2001 48 : 690 5.
17. Coffin B, Azpiroz F, Malagelada JR. Somatic stimulation reduces perception of gut distention in humans. Gastroenterology 1994 107 : 1636 42.
18. Serra J, Azpiroz F, Malagelada JR. Perception and reflex responses to intestinal distention in humans are modified by simultaneous or previous stimulation. Gastroenterology 1995 109 : 1742 9.
19. Schuligoi R, Jocic M, Heinemann A, Schoninkle E, Pabst MA, Holzer P. Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents. Gastroenterology 1998 115 : 649 60.
20. Kiviluoto T, Voipio J, Kivilaakso E. Subepithelial tissue pH of rat gastric mucosa exposed to luminal acid, barrier breaking agents, and hemorrhagic shock. Gastroenterology 1988 94 : 695 702.
21. Vogelsang H, Oberhuber G, Wyatt J. Lymphocytic gastritis and gastric permeability in patients with celiac disease. Gastroenterology 1996 111 : 73 7.
22. Lamb K, Kang YM, Gebhart GF, Bielefeldt K. Gastric inflammation triggers hypersensitivity to acid in awake rats. Gastroenterology 2003 125 : 1410 18.
23. Meddings JB, Swain MG. Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. Gastroenterology 2000 119 : 1019 28.