Acid challenge delays gastric pressure adaptation, blocks gastric emptying and stimulates gastric fluid secretion in the rat

Neurogastroenterology and Motility

Volumn 15, Issue 1, 2003, Pages 45-55

  Holzer, P ^a   Painsipp, E ^a   Jocic, M ^a   Heinemann, A ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Coeliac ganglion; Extrinsic innervation of the stomach; Gastric emptying; Gastric motor activity; Nitric oxide; Vagus nerve

Indexed keywords

HYDROCHLORIC ACID; NITRIC OXIDE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ARTICLE; CATHETER; CONTROLLED STUDY; DYSPEPSIA; FEMALE; INNERVATION; MOTOR ACTIVITY; MOTOR DYSFUNCTION; NERVE TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PYLORUS; RAT; STOMACH EMPTYING; STOMACH JUICE; STOMACH PRESSURE; STOMACH SECRETION;

ANIMALS; CELIAC PLEXUS; ENZYME INHIBITORS; FEMALE; GANGLIONECTOMY; GASTRIC EMPTYING; GASTRIC JUICE; GASTROINTESTINAL MOTILITY; HYDROCHLORIC ACID; NEURAL PATHWAYS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; VAGOTOMY; VAGUS NERVE;

EID: 0037294055     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2982.2003.00382.x     Document Type: Article

References (32)

1. Mayer EA. The physiology of gastric storage and emptying. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract, 3rd edn. New York: Raven Press, 1994: 929-76.
2. Kellow JE, Delvaux M, Azpiroz F, Camilleri M, Thompson DG, Quigley EMM. Principles of applied neurogastroenterology: physiology/motility-sensation. In: Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead WE, eds. Rome II - The Functional Gastrointestinal Disorders. McLean: Degnon Associates, 2000: 91-156.
3. Allescher HD, Bockenhoff A, Knapp G, Wienbeck M, Hartung J. Treatment of non-ulcer dyspepsia: a meta-analysis of placebo-controlled prospective studies. Scand J Gastroenterol 2001; 36: 934-41.
4. Quartero AO, Numans ME, de Melker RA, Hoes AW, de Wit NJ. Dyspepsia in primary care: acid suppression as effective as prokinetic therapy. A randomized clinical trial. Scand J Gastroenterol 2001; 36: 942-7.
5. 2-receptor antagonists in the treatment of functional (nonulcer) dyspepsia: a meta-analysis of randomized controlled clinical trials. Aliment Pharmacol Ther 2001; 15: 1291-9.
6. Schwartz MP, Samsom M, Van Berge Henegouwen GP, Smout AJ. Effect of inhibition of gastric acid secretion on antropyloroduodenal motor activity and duodenal acid hypersensitivity in functional dyspepsia. Aliment Pharmacol Ther 2001; 15: 1921-8.
7. Son HJ, Rhee PL, Kim JJ, Koh KC, Paik SW, Rhee JC. Hypersensitivity to acid in ulcer-like functional dyspepsia. Korean J Intern Med 1997; 12: 188-92.
8. Samsom M, Verhagen MA, vanBerge Henegouwen GP, Smout AJ. Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients. Gastroenterology 1999; 116: 515-20.
9. Collen MJ, Loebenberg MJ. Basal gastric acid secretion in nonulcer dyspepsia with or without duodenitis. Dig Dis Sci 1989; 34: 246-50.
10. Read NW. Functional dyspepsia: a case of indecision. Gastroenterology 1999; 116: 761-2.
11. Coffin B, Chollet R, Flourié B et al. Intraluminal modulation of gastric sensitivity to distension: effects of hydrochloric acid and meal. Am J Physiol 2001; 280: G904-9.
12. Hatakeyama Y, Matsuo M, Tomoi M, Ohtsuka M, Shimomura K. Luminal dilution caused by certain mild irritants and capsaicin contributes to their gastric mucosal protection. Am J Physiol 1995; 268: G200-6.
13. Cervero F, McRitchie HA. Neonatal capsaicin does not affect unmyelinated efferent fibers of the autonomic nervous system: functional evidence. Brain Res 1982; 239: 283-8.
14. Lu YX, Owyang C. Duodenal acid-induced gastric relaxation is mediated by multiple pathways. Am J Physiol 1999; 276: G1501-6.
15. Schuligoi R, Jocic M, Heinemann A, Schöninkle E, Pabst MA, Holzer P. Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents. Gastroenterology 1998; 115: 649-60.
16. Van der Schaar PJ, Lamers CBHW, Masclee AAM. Acid suppression enhances postprandial relaxation of the fundus in patients with functional dyspepsia. Neurogastroenterol Mot 2000; 12: 271.
17. Desai KM, Zembowicz A, Sessa WC, Vane JR. Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proc Natl Acad Sci USA 1991; 88: 11490-4.
18. Desai KM, Sessa WC, Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 1991; 351: 477-9.
19. Hennig GW, Brookes SJH, Costa M. Excitatory and inhibitory motor reflexes in the isolated guinea-pig stomach. J Physiol (London) 1997; 501: 197-212.
20. Takahashi T, Owyang C. Characterization of vagal pathways mediating gastric accommodation reflex in rats. J Physiol (London) 1997; 504: 479-88.
21. Uno H, Arakawa T, Fukuda T, Higuchi K, Kobayashi K. Involvement of capsaicin-sensitive sensory nerves in gastric adaptive relaxation in isolated guinea-pig stomachs. Digestion 1997; 58: 232-9.
22. Holzer P, Lippe IT. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 1988; 27: 981-7.
23. Holzer P, Lippe IT. Gastric mucosal hyperemia due to acid backdiffusion depends on splanchnic nerve activity. Am J Physiol 1992; 262: G505-9.
24. Holzer P. Reflex gastric motor inhibition caused by intraperitoneal bradykinin: antagonism by Hoe 140, a bradykinin antagonist. Peptides 1992; 13: 1073-7.
25. Heinemann A, Wachter CH, Holzer P. Differential regulation of mesenteric and femoral blood flow in the rat as revealed by computerized data acquisition and evaluation. J Auton Pharmacol 1998; 18: 39-48.
26. Rees DD, Palmer RMJ, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990; 101: 746-752.
27. Allescher HD, Daniel EE, Dent J, Fox JE, Kostolanska F. Neural reflex of the canine pylorus to intraduodenal acid infusion. Gastroenterology 1989; 96: 18-28.
28. Yuan SY, Costa M, Brookes SJH. Neuronal control of the pyloric sphincter of the guinea-pig. Neurogastroenterol Mot 2001; 13: 187-98.
29. Allescher HD, Daniel EE, Dent J, Fox JE, Kostolanska F. Extrinsic and intrinsic neural control of pyloric sphincter pressure in the dog. J Physiol (London) 1988; 401: 17-38.
30. Malbert CH, Mathis C, Laplace JP. Vagal control of pyloric resistance. Am J Physiol 1995; 269: G558-69.
31. De Ponti F, Giaroni C, Cosentino M, Lecchini S, Frigo G. Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol Ther 1996; 69: 59-78.
32. Ishiguchi T, Nishioka S, Takahashi T. Inhibitory neural pathway regulating gastric emptying in rats. J Auton Nerv Syst 2000; 79: 45-51.