High yield detritylation of surface-attached nucleosides with photoacid generated in an overlying solid film: Roles of translational diffusion and scavenging

Organic and Biomolecular Chemistry

Volumn 7, Issue 3, 2009, Pages 451-459

  Garland, Peter B ^a   Serafinowski, Pawel J ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; COMPUTER SYSTEM RECOVERY; MOLECULAR DYNAMICS; NUCLEOTIDES; OLIGONUCLEOTIDES; SCAVENGING; STATISTICAL MECHANICS; SURFACE DIFFUSION; SYNTHESIS (CHEMICAL);

CARBOCATION; DETRITYLATION; HIGH YIELDS; IRREVERSIBLE PROCESS; OLIGONUCLEOTIDE ARRAYS; OLIGONUCLEOTIDE SYNTHESIS; PHOTO GENERATIONS; PHOTOACID; PLANAR SURFACES; SOLID FILMS; SOLID-PHASE; TIME DEPENDENTS; TRANSLATIONAL DIFFUSIONS; TRICHLOROACETIC ACIDS; WASHING AWAY;

DILATOMETERS;

4,4' DIMETHOXYTRITYL CATION; 4,4'-DIMETHOXYTRITYL CATION; NUCLEOSIDE; PLASTICIZER; TRICHLOROACETIC ACID; TRITYL DERIVATIVE;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DIFFUSION; KINETICS; LIGHT; PHOTOLYSIS; SURFACE PROPERTY; TIME;

COMPUTER SIMULATION; DIFFUSION; KINETICS; LIGHT; MODELS, CHEMICAL; NUCLEOSIDES; PHOTOLYSIS; PLASTICIZERS; SURFACE PROPERTIES; TIME FACTORS; TRICHLOROACETIC ACID; TRITYL COMPOUNDS;

EID: 58849100861     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b813319k     Document Type: Article

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4. +; 4,4′-dimethoxytrityl carbocation; DMT-T, 5′-O-DMT-thymidine; ester 1, α-phenyl-4,5- dimethoxy-2-nitrobenzyltrichloroacetate; ester 2, α-phenyl-4,5-dimethoxy- 2,6-dinitrobenzyltrichloroacetate; ester 6, α-phenyl-5-chloro-2-nitro- benzyltrichloroacetate; ester 7, α-phenyl-5-chloro-2,6-dinitrobenzyl- trichloroacetate; MPDPS, 4-(methoxyphenyl)-diphenyl-silane; PAG, photoacid generator; PMS, poly(α-methylstyrene); TCA, trichloro-acetic acid; TPM, triphenylmethane; TPS, triphenylsilane; TPTH, triphenyltinhydride
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