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Volumn 37, Issue SUPPL. 1, 2009, Pages

The clinical research enterprise in critical care: What's right, what's wrong, and what's ahead?

Author keywords

Clinical trials; Intensive care; Phase II; Phase III; Priority; Research

Indexed keywords

CLINICAL RESEARCH; CLINICAL STUDY; EVIDENCE BASED MEDICINE; INTENSIVE CARE; MEDICAL PRACTICE; METHODOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROFESSIONAL PRACTICE; REVIEW; SCIENCE; SCIENTIST; ARTICLE; CLINICAL TRIAL; FINANCIAL MANAGEMENT; HUMAN; MEDICAL RESEARCH; ORGANIZATION AND MANAGEMENT;

EID: 58849099213     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318192074c     Document Type: Editorial
Times cited : (12)

References (93)
  • 1
    • 0034682246 scopus 로고    scopus 로고
    • Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
    • Kress JP, Pohlman AS, O'Connor MF, et al: Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000; 342: 1471-1477
    • (2000) N Engl J Med , vol.342 , pp. 1471-1477
    • Kress, J.P.1    Pohlman, A.S.2    O'Connor, M.F.3
  • 2
    • 10544248173 scopus 로고    scopus 로고
    • Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously
    • Ely EW, Baker AM, Dunagan DP, et al: Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med 1996; 335: 1864-1869
    • (1996) N Engl J Med , vol.335 , pp. 1864-1869
    • Ely, E.W.1    Baker, A.M.2    Dunagan, D.P.3
  • 3
    • 0033610663 scopus 로고    scopus 로고
    • Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: A randomised trial
    • Drakulovic MB, Torres A, Bauer TT, et al: Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: A randomised trial. Lancet 1999; 354:1851-1858
    • (1999) Lancet , vol.354 , pp. 1851-1858
    • Drakulovic, M.B.1    Torres, A.2    Bauer, T.T.3
  • 4
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • Rivers E, Nguyen B, Havstad S, et al: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
    • (2001) N Engl J Med , vol.345 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3
  • 5
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal as compared with traditional tidal for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342: 1301-1308
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342: 1301-1308
  • 6
    • 13444283301 scopus 로고    scopus 로고
    • Hypothermia for neuroprotection after cardiac arrest: Systematic review and individual patient data meta-analysis
    • Holzer M, Bernard SA, Hachimi-Idrissi S, et al: Hypothermia for neuroprotection after cardiac arrest: Systematic review and individual patient data meta-analysis. Crit Care Med 2005; 33:414-418
    • (2005) Crit Care Med , vol.33 , pp. 414-418
    • Holzer, M.1    Bernard, S.A.2    Hachimi-Idrissi, S.3
  • 7
    • 0343360868 scopus 로고    scopus 로고
    • A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group
    • Hebert PC, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340: 409-417
    • (1999) N Engl J Med , vol.340 , pp. 409-417
    • Hebert, P.C.1    Wells, G.2    Blajchman, M.A.3
  • 8
    • 23444461703 scopus 로고    scopus 로고
    • Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): A randomised controlled trial
    • Harvey S, Harrison DA, Singer M, et al: Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): A randomised controlled trial. Lancet 2005; 366: 472-477
    • (2005) Lancet , vol.366 , pp. 472-477
    • Harvey, S.1    Harrison, D.A.2    Singer, M.3
  • 9
    • 0037413466 scopus 로고    scopus 로고
    • A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients
    • Sandham JD, Hull RD, Brant RF, et al: A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med 2003; 348:5-14
    • (2003) N Engl J Med , vol.348 , pp. 5-14
    • Sandham, J.D.1    Hull, R.D.2    Brant, R.F.3
  • 10
    • 0345374592 scopus 로고    scopus 로고
    • Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: A randomized controlled trial
    • Richard C, Warszawski J, Anguel N, et al: Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2003; 290: 2713-2720
    • (2003) JAMA , vol.290 , pp. 2713-2720
    • Richard, C.1    Warszawski, J.2    Anguel, N.3
  • 11
    • 33646859471 scopus 로고    scopus 로고
    • Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury
    • Wheeler AP, Bernard GR, Thompson BT, et al: Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006; 354:2213-2224
    • (2006) N Engl J Med , vol.354 , pp. 2213-2224
    • Wheeler, A.P.1    Bernard, G.R.2    Thompson, B.T.3
  • 12
    • 0034509672 scopus 로고    scopus 로고
    • Low-dose dopamine in patients with early renal dysfunction: A placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group
    • Bellomo R, Chapman M, Finfer S, et al: Low-dose dopamine in patients with early renal dysfunction: A placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 2000; 356:2139-2143
    • (2000) Lancet , vol.356 , pp. 2139-2143
    • Bellomo, R.1    Chapman, M.2    Finfer, S.3
  • 13
    • 34547473024 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in severe sepsis: A systematic review and new cost-effectiveness analysis
    • Costa V, Brophy JM: Drotrecogin alfa (activated) in severe sepsis: A systematic review and new cost-effectiveness analysis. BMC Anesthesiol 2007; 7:5
    • (2007) BMC Anesthesiol , vol.7 , pp. 5
    • Costa, V.1    Brophy, J.M.2
  • 14
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 15
    • 0030846060 scopus 로고    scopus 로고
    • When to base clinical policies on observational versus randomized trial data
    • Hornberger J, Wrone E: When to base clinical policies on observational versus randomized trial data. Ann Intern Med 1997; 127: 697-703
    • (1997) Ann Intern Med , vol.127 , pp. 697-703
    • Hornberger, J.1    Wrone, E.2
  • 16
    • 0037174359 scopus 로고    scopus 로고
    • Anemia and blood transfusion in critically ill patients
    • Vincent JL, Baron JF, Reinhart K, et al: Anemia and blood transfusion in critically ill patients. JAMA 2002; 288:1499-1507
    • (2002) JAMA , vol.288 , pp. 1499-1507
    • Vincent, J.L.1    Baron, J.F.2    Reinhart, K.3
  • 17
    • 0036174381 scopus 로고    scopus 로고
    • Randomized, controlled clinical trials in sepsis: Has methodological quality improved over time?
    • Graf J, Doig GS, Cook DJ, et al: Randomized, controlled clinical trials in sepsis: Has methodological quality improved over time? Crit Care Med 2002; 30:461-472
    • (2002) Crit Care Med , vol.30 , pp. 461-472
    • Graf, J.1    Doig, G.S.2    Cook, D.J.3
  • 18
    • 67749135002 scopus 로고    scopus 로고
    • Organizing clinical critical care research and implementing the results
    • Fink MP, Suter PM, Sibbald WJ Eds, Berlin, Springer-Verlag
    • Cook D, Finfer S: Organizing clinical critical care research and implementing the results. In: Intensive Care Medicine in 10 Years. Fink MP, Suter PM, Sibbald WJ (Eds). Berlin, Springer-Verlag, 2006, pp 311-323
    • (2006) Intensive Care Medicine in 10 Years , pp. 311-323
    • Cook, D.1    Finfer, S.2
  • 19
    • 0031968322 scopus 로고    scopus 로고
    • Training pulmonary and critical care physicians in outcomes research: Should we take the challenge?
    • Curtis JR, Rubenfeld GD, Hudson LD: Training pulmonary and critical care physicians in outcomes research: Should we take the challenge? Am J Respir Crit Care Med 1998; 157: 1012-1015
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1012-1015
    • Curtis, J.R.1    Rubenfeld, G.D.2    Hudson, L.D.3
  • 20
    • 67749097250 scopus 로고    scopus 로고
    • Available at:, Accessed October 15, 2007
    • Chandler E, Langford P: Are there more critical care physicians today? 2006. Available at: http://www.sccm.org/SCCM/Publications/ Critical+Connections/ Archives/June+2006/ workforce-June06.htm. Accessed October 15, 2007
    • (2006) Are there more critical care physicians today
    • Chandler, E.1    Langford, P.2
  • 21
    • 19044381385 scopus 로고    scopus 로고
    • Survey shows serious shortage of medical academics in the UK
    • MacDonald R: Survey shows serious shortage of medical academics in the UK. BMJ 2002; 324:446
    • (2002) BMJ , vol.324 , pp. 446
    • MacDonald, R.1
  • 22
    • 30344478582 scopus 로고    scopus 로고
    • Can we make training in surgical critical care more attractive?
    • Richardson JD, Franklin GA, Rodriguez JL: Can we make training in surgical critical care more attractive? J Trauma 2005; 59: 1247-1248
    • (2005) J Trauma , vol.59 , pp. 1247-1248
    • Richardson, J.D.1    Franklin, G.A.2    Rodriguez, J.L.3
  • 24
    • 0037289751 scopus 로고    scopus 로고
    • Of mice and men (and rats): Implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis
    • Reade MC, Young JD: Of mice and men (and rats): Implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis. Br J Anaesth 2003; 90:115-118
    • (2003) Br J Anaesth , vol.90 , pp. 115-118
    • Reade, M.C.1    Young, J.D.2
  • 25
    • 0038298224 scopus 로고    scopus 로고
    • Effects of in vivo lipopolysaccharide infusion on vasoconstrictor function of rat isolated mesentery, kidney, and aorta
    • Farmer MR, Roberts RE, Gardiner SM, et al: Effects of in vivo lipopolysaccharide infusion on vasoconstrictor function of rat isolated mesentery, kidney, and aorta. J Pharmacol Exp Ther 2003; 306:538-545
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 538-545
    • Farmer, M.R.1    Roberts, R.E.2    Gardiner, S.M.3
  • 26
    • 0032942416 scopus 로고    scopus 로고
    • Expired nitric oxide and shock in higher order species
    • Traber DL: Expired nitric oxide and shock in higher order species. Crit Care Med 1999; 27:255-256
    • (1999) Crit Care Med , vol.27 , pp. 255-256
    • Traber, D.L.1
  • 27
    • 0037433442 scopus 로고    scopus 로고
    • Central challenges facing the national clinical research enterprise
    • Sung NS, Crowley WF Jr, Genel M, et al: Central challenges facing the national clinical research enterprise. JAMA 2003; 289: 1278-1287
    • (2003) JAMA , vol.289 , pp. 1278-1287
    • Sung, N.S.1    Crowley Jr, W.F.2    Genel, M.3
  • 28
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
    • Abraham E, Reinhart K, Opal S, et al: Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial. JAMA 2003; 290:238-247
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3
  • 29
    • 0033816376 scopus 로고    scopus 로고
    • Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis
    • Abraham E: Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis. Crit Care Med 2000; 28: S31-S33
    • (2000) Crit Care Med , vol.28
    • Abraham, E.1
  • 30
    • 8544262221 scopus 로고    scopus 로고
    • Efficacy and safety of the monoclonal antitumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
    • Panacek EA, Marshall JC, Albertson TE, et al: Efficacy and safety of the monoclonal antitumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 2004; 32:2173-2182
    • (2004) Crit Care Med , vol.32 , pp. 2173-2182
    • Panacek, E.A.1    Marshall, J.C.2    Albertson, T.E.3
  • 31
    • 0034895949 scopus 로고    scopus 로고
    • A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome
    • Gallagher J, Fisher C, Sherman B, et al: A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome. Intensive Care Med 2001; 27:1169-1178
    • (2001) Intensive Care Med , vol.27 , pp. 1169-1178
    • Gallagher, J.1    Fisher, C.2    Sherman, B.3
  • 32
    • 9344246862 scopus 로고    scopus 로고
    • Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study
    • Reinhart K, Wiegand-Lohnert C, Grimminger F, et al: Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 1996; 24: 733-742
    • (1996) Crit Care Med , vol.24 , pp. 733-742
    • Reinhart, K.1    Wiegand-Lohnert, C.2    Grimminger, F.3
  • 33
    • 85120186858 scopus 로고    scopus 로고
    • MONARCS. Statistical or clinical meaning?
    • Jaimes FA: MONARCS. Statistical or clinical meaning? Crit Care Med 2005; 33:2144-2146
    • (2005) Crit Care Med , vol.33 , pp. 2144-2146
    • Jaimes, F.A.1
  • 34
    • 0038013891 scopus 로고    scopus 로고
    • Unraveling severe sepsis: Why did OPTIMIST fail and what's next?
    • Angus DC, Crowther MA: Unraveling severe sepsis: Why did OPTIMIST fail and what's next? JAMA 2003; 290:256-258
    • (2003) JAMA , vol.290 , pp. 256-258
    • Angus, D.C.1    Crowther, M.A.2
  • 35
    • 34548022149 scopus 로고    scopus 로고
    • Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) study
    • Kellum JA, Kong L, Fink MP, et al: Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) study. Arch Intern Med 2007; 167: 1655-1663
    • (2007) Arch Intern Med , vol.167 , pp. 1655-1663
    • Kellum, J.A.1    Kong, L.2    Fink, M.P.3
  • 36
    • 67749099097 scopus 로고    scopus 로고
    • FDA unveils critical path opportunities, Available at:, Accessed September 24, 2007
    • FDA unveils critical path opportunities. US Food and Drug Administration. 2007. Available at: http://www.fda.gov/bbs/topics/news/ 2006/NEW01336.html. Accessed September 24, 2007
    • (2007)
  • 37
    • 1342265610 scopus 로고    scopus 로고
    • Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: Cluster-randomised, single-blinded intervention trial
    • Christ-Crain M, Jaccard-Stolz D, Bingisser R, et al: Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: Cluster-randomised, single-blinded intervention trial. Lancet 2004; 363:600-607
    • (2004) Lancet , vol.363 , pp. 600-607
    • Christ-Crain, M.1    Jaccard-Stolz, D.2    Bingisser, R.3
  • 38
    • 34247860864 scopus 로고    scopus 로고
    • Phase II trials published in 2002: A cross-specialty comparison showing significant design differences between oncology trials and other medical specialties
    • Michaelis LC, Ratain MJ: Phase II trials published in 2002: A cross-specialty comparison showing significant design differences between oncology trials and other medical specialties. Clin Cancer Res 2007; 13:2400-2405
    • (2007) Clin Cancer Res , vol.13 , pp. 2400-2405
    • Michaelis, L.C.1    Ratain, M.J.2
  • 39
    • 34247855051 scopus 로고    scopus 로고
    • Phase II cancer trials: Out of control?
    • Chabner B: Phase II cancer trials: Out of control? Clin Cancer Res 2007; 13: 2307-2308
    • (2007) Clin Cancer Res , vol.13 , pp. 2307-2308
    • Chabner, B.1
  • 40
    • 27244440177 scopus 로고    scopus 로고
    • Comparison of outcomes of phase II studies and subsequent randomized control studies using identical chemotherapeutic regimens
    • Zia MI, Siu LL, Pond GR, et al: Comparison of outcomes of phase II studies and subsequent randomized control studies using identical chemotherapeutic regimens. J Clin Oncol 2005; 23:6982-6991
    • (2005) J Clin Oncol , vol.23 , pp. 6982-6991
    • Zia, M.I.1    Siu, L.L.2    Pond, G.R.3
  • 41
    • 3042598428 scopus 로고    scopus 로고
    • Screening of ARDS patients using standardized ventilator settings: Influence on enrollment in a clinical trial
    • Ferguson ND, Kacmarek RM, Chiche JD, et al: Screening of ARDS patients using standardized ventilator settings: Influence on enrollment in a clinical trial. Intensive Care Med 2004; 30:1111-1116
    • (2004) Intensive Care Med , vol.30 , pp. 1111-1116
    • Ferguson, N.D.1    Kacmarek, R.M.2    Chiche, J.D.3
  • 42
    • 0030051905 scopus 로고    scopus 로고
    • Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients
    • Pittet D, Thievent B, Wenzel RP, et al: Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients. Am J Respir Crit Care Med 1996; 153: 684-693
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 684-693
    • Pittet, D.1    Thievent, B.2    Wenzel, R.P.3
  • 43
    • 31344461826 scopus 로고    scopus 로고
    • Sepsis in European intensive care units: Results of the SOAP study
    • Vincent JL, Sakr Y, Sprung CL, et al: Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med 2006; 34: 344-353
    • (2006) Crit Care Med , vol.34 , pp. 344-353
    • Vincent, J.L.1    Sakr, Y.2    Sprung, C.L.3
  • 44
    • 4344711662 scopus 로고    scopus 로고
    • Severe sepsis epidemiology: Sampling, selection, and society
    • Linde-Zwirble WT, Angus DC: Severe sepsis epidemiology: Sampling, selection, and society. Crit Care 2004; 8:222-226
    • (2004) Crit Care , vol.8 , pp. 222-226
    • Linde-Zwirble, W.T.1    Angus, D.C.2
  • 45
    • 84892258025 scopus 로고    scopus 로고
    • International comparisons of intensive care: Understanding the differences
    • Vincent JL Ed, Berlin, Springer-Verlag
    • Wunsch H, Angus DC: International comparisons of intensive care: Understanding the differences. In: Yearbook of Intensive Care and Emergency Medicine. Vincent JL (Ed). Berlin, Springer-Verlag, 2006, pp 787-793
    • (2006) Yearbook of Intensive Care and Emergency Medicine , pp. 787-793
    • Wunsch, H.1    Angus, D.C.2
  • 46
    • 67749090547 scopus 로고    scopus 로고
    • The Australian and New Zealand Intensive Care Society Clinical Trials Group, Available at
    • The Australian and New Zealand Intensive Care Society Clinical Trials Group. 2007. Available at: http://www.anzics.com.au/ctg/
    • (2007)
  • 47
    • 67749095379 scopus 로고    scopus 로고
    • Canadian Critical Care Trials Group, Available at
    • Canadian Critical Care Trials Group. 2005. Available at: http://www.ccctg.ca/index.php
    • (2005)
  • 49
    • 0035829852 scopus 로고    scopus 로고
    • Intensive insulin therapy in the critically ill patients
    • van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
    • (2001) N Engl J Med , vol.345 , pp. 1359-1367
    • van den Berghe, G.1    Wouters, P.2    Weekers, F.3
  • 50
    • 30344439512 scopus 로고    scopus 로고
    • Intensive insulin therapy in critical illness
    • Angus DC, Abraham E: Intensive insulin therapy in critical illness. Am J Respir Crit Care Med 2005; 172:1358-1359
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 1358-1359
    • Angus, D.C.1    Abraham, E.2
  • 51
    • 33947161625 scopus 로고    scopus 로고
    • Early goal-directed therapy of septic shock: We honestly remain skeptical
    • Peake S, Webb S, Delaney A: Early goal-directed therapy of septic shock: We honestly remain skeptical. Crit Care Med 2007; 35: 994-995
    • (2007) Crit Care Med , vol.35 , pp. 994-995
    • Peake, S.1    Webb, S.2    Delaney, A.3
  • 52
    • 0036892747 scopus 로고    scopus 로고
    • Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes
    • Eichacker PQ, Gerstenberger EP, Banks SM, et al: Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. Am J Respir Crit Care Med 2002; 166:1510-1514
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1510-1514
    • Eichacker, P.Q.1    Gerstenberger, E.P.2    Banks, S.M.3
  • 53
    • 0036214865 scopus 로고    scopus 로고
    • Physician knowledge and practices in the evaluation of coagulopathies in stroke patients
    • Bushnell CD, Goldstein LB: Physician knowledge and practices in the evaluation of coagulopathies in stroke patients. Stroke 2002; 33:948-953
    • (2002) Stroke , vol.33 , pp. 948-953
    • Bushnell, C.D.1    Goldstein, L.B.2
  • 54
    • 0026651608 scopus 로고
    • A comparison of observed and self-reported compliance with universal precautions among emergency department personnel at a Minnesota public teaching hospital: Implications for assessing infection control programs
    • Henry K, Campbell S, Maki M: A comparison of observed and self-reported compliance with universal precautions among emergency department personnel at a Minnesota public teaching hospital: Implications for assessing infection control programs. Ann Emerg Med 1992; 21:940-946
    • (1992) Ann Emerg Med , vol.21 , pp. 940-946
    • Henry, K.1    Campbell, S.2    Maki, M.3
  • 56
    • 33646893271 scopus 로고    scopus 로고
    • Management of blood glucose in the critically ill in Australia and New Zealand: A practice survey and inception cohort study
    • Mitchell I, Finfer S, Bellomo R, et al: Management of blood glucose in the critically ill in Australia and New Zealand: A practice survey and inception cohort study. Intensive Care Med 2006; 32:867-874
    • (2006) Intensive Care Med , vol.32 , pp. 867-874
    • Mitchell, I.1    Finfer, S.2    Bellomo, R.3
  • 57
    • 0031937056 scopus 로고    scopus 로고
    • A Canadian survey of transfusion practices in critically ill patients. Transfusion Requirements in Critical Care Investigators and the Canadian Critical Care Trials Group
    • Hebert PC, Wells G, Martin C, et al: A Canadian survey of transfusion practices in critically ill patients. Transfusion Requirements in Critical Care Investigators and the Canadian Critical Care Trials Group. Crit Care Med 1998; 26:482-487
    • (1998) Crit Care Med , vol.26 , pp. 482-487
    • Hebert, P.C.1    Wells, G.2    Martin, C.3
  • 58
    • 35349027929 scopus 로고    scopus 로고
    • Resuscitating patients with early severe sepsis: A Canadian multicentre observational study [Reanimation des patients en debut de sepsie severe: une etude observationnelle multi-centrique canadienne]
    • McIntyre LA, Fergusson D, Cook DJ, et al: Resuscitating patients with early severe sepsis: A Canadian multicentre observational study [Reanimation des patients en debut de sepsie severe: une etude observationnelle multi-centrique canadienne]. Can J Anaesth 2007; 54:790-798
    • (2007) Can J Anaesth , vol.54 , pp. 790-798
    • McIntyre, L.A.1    Fergusson, D.2    Cook, D.J.3
  • 59
    • 2942709621 scopus 로고    scopus 로고
    • Endpoints in sepsis trials: More than just 28-day mortality?
    • Vincent JL: Endpoints in sepsis trials: More than just 28-day mortality? Crit Care Med 2004; 32:S209-S213
    • (2004) Crit Care Med , vol.32
    • Vincent, J.L.1
  • 60
    • 0035054111 scopus 로고    scopus 로고
    • New strategies for clinical trials in patients with sepsis and septic shock
    • Cohen J, Guyatt G, Bernard GR, et al: New strategies for clinical trials in patients with sepsis and septic shock. Crit Care Med 2001; 29:880-886
    • (2001) Crit Care Med , vol.29 , pp. 880-886
    • Cohen, J.1    Guyatt, G.2    Bernard, G.R.3
  • 61
    • 14944340587 scopus 로고    scopus 로고
    • One-year mortality of bloodstream infectionassociated sepsis and septic shock among patients presenting to a regional critical care system
    • Laupland KB, Zygun DA, Doig CJ, et al: One-year mortality of bloodstream infectionassociated sepsis and septic shock among patients presenting to a regional critical care system. Intensive Care Med 2005; 31: 213-219
    • (2005) Intensive Care Med , vol.31 , pp. 213-219
    • Laupland, K.B.1    Zygun, D.A.2    Doig, C.J.3
  • 62
    • 33947667912 scopus 로고    scopus 로고
    • Influence of comorbid conditions on long-term mortality after pneumonia in older people
    • Yende S, Angus DC, Ali IS, et al: Influence of comorbid conditions on long-term mortality after pneumonia in older people. J Am Geriatr Soc 2007; 55:518-525
    • (2007) J Am Geriatr Soc , vol.55 , pp. 518-525
    • Yende, S.1    Angus, D.C.2    Ali, I.S.3
  • 63
    • 0037394909 scopus 로고    scopus 로고
    • Improving clinical trial design in acute lung injury
    • Wood KA, Huang D, Angus DC: Improving clinical trial design in acute lung injury. Crit Care Med 2003; 31:S305-S311
    • (2003) Crit Care Med , vol.31
    • Wood, K.A.1    Huang, D.2    Angus, D.C.3
  • 64
    • 0037253093 scopus 로고    scopus 로고
    • Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    • Angus DC, Linde-Zwirble WT, Clermont G, et al: Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med 2003; 31:1-11
    • (2003) Crit Care Med , vol.31 , pp. 1-11
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Clermont, G.3
  • 65
    • 0021823781 scopus 로고
    • Extracorporeal circulation in neonatal respiratory failure: A prospective randomized study
    • Bartlett RH, Roloff DW, Cornell RG, et al: Extracorporeal circulation in neonatal respiratory failure: A prospective randomized study. Pediatrics 1985; 76:479-487
    • (1985) Pediatrics , vol.76 , pp. 479-487
    • Bartlett, R.H.1    Roloff, D.W.2    Cornell, R.G.3
  • 66
    • 0032054154 scopus 로고    scopus 로고
    • The cost-benefit of a randomized trial to a health care organization
    • Hornberger J, Eghtesady P: The cost-benefit of a randomized trial to a health care organization. Control Clin Trials 1998; 19: 198-211
    • (1998) Control Clin Trials , vol.19 , pp. 198-211
    • Hornberger, J.1    Eghtesady, P.2
  • 67
    • 0030897458 scopus 로고    scopus 로고
    • Intravenous insulin-like growth factor-I (IGF-I) in moderate-to-severe head injury: A phase II safety and efficacy trial
    • Hatton J, Rapp RP, Kudsk KA, et al: Intravenous insulin-like growth factor-I (IGF-I) in moderate-to-severe head injury: A phase II safety and efficacy trial. J Neurosurg 1997; 86:779-786
    • (1997) J Neurosurg , vol.86 , pp. 779-786
    • Hatton, J.1    Rapp, R.P.2    Kudsk, K.A.3
  • 68
    • 3943092597 scopus 로고    scopus 로고
    • Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected gram-negative sepsis
    • Reinhart K, Meier-Hellmann A, Beale R, et al: Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected gram-negative sepsis. Crit Care Med 2004; 32:1662-1668
    • (2004) Crit Care Med , vol.32 , pp. 1662-1668
    • Reinhart, K.1    Meier-Hellmann, A.2    Beale, R.3
  • 69
    • 0034884033 scopus 로고    scopus 로고
    • Total extracorporeal arteriovenous carbon dioxide removal in acute respiratory failure: A phase I clinical study
    • Conrad SA, Zwischenberger JB, Grier LR, et al: Total extracorporeal arteriovenous carbon dioxide removal in acute respiratory failure: A phase I clinical study. Intensive Care Med 2001; 27:1340-1351
    • (2001) Intensive Care Med , vol.27 , pp. 1340-1351
    • Conrad, S.A.1    Zwischenberger, J.B.2    Grier, L.R.3
  • 70
    • 0030967622 scopus 로고    scopus 로고
    • High-frequency oscillatory ventilation for adult respiratory distress syndrome - A pilot study
    • Fort P, Farmer C, Westerman J, et al: High-frequency oscillatory ventilation for adult respiratory distress syndrome - A pilot study. Crit Care Med 1997; 25:937-947
    • (1997) Crit Care Med , vol.25 , pp. 937-947
    • Fort, P.1    Farmer, C.2    Westerman, J.3
  • 71
    • 0034945691 scopus 로고    scopus 로고
    • A pilot study to investigate the effects of an infusion of aminophylline on renal function following major abdominal surgery
    • Parker MR, Willatts SM: A pilot study to investigate the effects of an infusion of aminophylline on renal function following major abdominal surgery. Anaesthesia 2001; 56: 670-675
    • (2001) Anaesthesia , vol.56 , pp. 670-675
    • Parker, M.R.1    Willatts, S.M.2
  • 72
    • 33750113630 scopus 로고    scopus 로고
    • Use of dexmedetomidine to facilitate extubation in surgical intensive-care-unit patients who failed previous weaning attempts following prolonged mechanical ventilation: A pilot study
    • Siobal MS, Kallet RH, Kivett VA, et al: Use of dexmedetomidine to facilitate extubation in surgical intensive-care-unit patients who failed previous weaning attempts following prolonged mechanical ventilation: A pilot study. Respir Care 2006; 51:492-496
    • (2006) Respir Care , vol.51 , pp. 492-496
    • Siobal, M.S.1    Kallet, R.H.2    Kivett, V.A.3
  • 73
    • 0037006134 scopus 로고    scopus 로고
    • Managing conflicts of interest in the conduct of clinical trials
    • Morin K, Rakatansky H, Riddick FA Jr, et al: Managing conflicts of interest in the conduct of clinical trials. JAMA 2002; 287:78-84
    • (2002) JAMA , vol.287 , pp. 78-84
    • Morin, K.1    Rakatansky, H.2    Riddick Jr, F.A.3
  • 74
    • 0025884214 scopus 로고
    • A randomized control trial of right-heart catheterization in critically ill patients. Ontario Intensive Care Study Group
    • Guyatt G: A randomized control trial of right-heart catheterization in critically ill patients. Ontario Intensive Care Study Group. J Intensive Care Med 1991; 6:91-95
    • (1991) J Intensive Care Med , vol.6 , pp. 91-95
    • Guyatt, G.1
  • 75
    • 0033845134 scopus 로고    scopus 로고
    • Enhancing cancer clinical trial management: Recommendations from a qualitative study of trial participants' experiences
    • Cox K: Enhancing cancer clinical trial management: Recommendations from a qualitative study of trial participants' experiences. Psychooncology 2000; 9:314-322
    • (2000) Psychooncology , vol.9 , pp. 314-322
    • Cox, K.1
  • 76
    • 0035116532 scopus 로고    scopus 로고
    • Do surrogate decision makers provide accurate consent for intensive care research?
    • Coppolino M, Ackerson L: Do surrogate decision makers provide accurate consent for intensive care research? Chest 2001; 119: 603-612
    • (2001) Chest , vol.119 , pp. 603-612
    • Coppolino, M.1    Ackerson, L.2
  • 77
    • 1542394625 scopus 로고    scopus 로고
    • Research governance: A barrier to ethical research?
    • Dumville JC, Watson J, Raynor P, et al: Research governance: A barrier to ethical research? QJM 2004; 97:113-114
    • (2004) QJM , vol.97 , pp. 113-114
    • Dumville, J.C.1    Watson, J.2    Raynor, P.3
  • 78
    • 0027849686 scopus 로고
    • The Cochrane collaboration: Preparing, maintaining, and disseminating systematic reviews of the effects of health care
    • Chalmers I: The Cochrane collaboration: Preparing, maintaining, and disseminating systematic reviews of the effects of health care. Ann N Y Acad Sci 1993; 703:156-163
    • (1993) Ann N Y Acad Sci , vol.703 , pp. 156-163
    • Chalmers, I.1
  • 80
    • 33847043499 scopus 로고    scopus 로고
    • Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials
    • Silvestri L, van Saene HK, Milanese M, et al: Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. J Hosp Infect 2007; 65:187-203
    • (2007) J Hosp Infect , vol.65 , pp. 187-203
    • Silvestri, L.1    van Saene, H.K.2    Milanese, M.3
  • 81
    • 28444433832 scopus 로고    scopus 로고
    • Thromboprophylaxis in medical-surgical intensive care unit patients
    • Cook D, Crowther MA, Douketis J: Thromboprophylaxis in medical-surgical intensive care unit patients. J Crit Care 2005; 20: 320-323
    • (2005) J Crit Care , vol.20 , pp. 320-323
    • Cook, D.1    Crowther, M.A.2    Douketis, J.3
  • 82
    • 37549020378 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger RP, Levy MM, Carlet JM, et al: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
    • (2008) Crit Care Med , vol.36 , pp. 296-327
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3
  • 83
    • 39049099457 scopus 로고    scopus 로고
    • Barriers to implementing protocol-based sepsis resuscitation in the emergency department - Results of a national survey
    • Carlbom DJ, Rubenfeld GD: Barriers to implementing protocol-based sepsis resuscitation in the emergency department - Results of a national survey. Crit Care Med 2007; 35:2525-2532
    • (2007) Crit Care Med , vol.35 , pp. 2525-2532
    • Carlbom, D.J.1    Rubenfeld, G.D.2
  • 84
    • 0037070518 scopus 로고    scopus 로고
    • From clinical trials to clinical practice: Bridging the GAP
    • Rich MW: From clinical trials to clinical practice: Bridging the GAP. JAMA 2002; 287: 1321-1323
    • (2002) JAMA , vol.287 , pp. 1321-1323
    • Rich, M.W.1
  • 85
    • 0032721879 scopus 로고    scopus 로고
    • Why don't physicians follow clinical practice guidelines? A framework for improvement
    • Cabana MD, Rand CS, Powe NR, et al: Why don't physicians follow clinical practice guidelines? A framework for improvement. JAMA 1999; 282:1458-1465
    • (1999) JAMA , vol.282 , pp. 1458-1465
    • Cabana, M.D.1    Rand, C.S.2    Powe, N.R.3
  • 86
    • 33750066637 scopus 로고    scopus 로고
    • Surviving sepsis - Practice guidelines, marketing campaigns, and Eli Lilly
    • Eichacker PQ, Natanson C, Danner RL: Surviving sepsis - Practice guidelines, marketing campaigns, and Eli Lilly. N Engl J Med 2006; 355:1640-1642
    • (2006) N Engl J Med , vol.355 , pp. 1640-1642
    • Eichacker, P.Q.1    Natanson, C.2    Danner, R.L.3
  • 87
    • 0032585183 scopus 로고    scopus 로고
    • Analysis and interpretation of cost data in randomised controlled trials: Review of published studies
    • Barber JA, Thompson SG: Analysis and interpretation of cost data in randomised controlled trials: Review of published studies. BMJ 1998; 317:1195-1200
    • (1998) BMJ , vol.317 , pp. 1195-1200
    • Barber, J.A.1    Thompson, S.G.2
  • 88
    • 33748336479 scopus 로고    scopus 로고
    • Analyses of cost data in economic evaluations conducted alongside randomized controlled trials
    • Doshi JA, Glick HA, Polsky D: Analyses of cost data in economic evaluations conducted alongside randomized controlled trials. Value Health 2006; 9:334-340
    • (2006) Value Health , vol.9 , pp. 334-340
    • Doshi, J.A.1    Glick, H.A.2    Polsky, D.3
  • 89
    • 34447281815 scopus 로고    scopus 로고
    • Relevance of cost-effectiveness analysis to clinicians and policy makers
    • Detsky AS, Laupacis A: Relevance of cost-effectiveness analysis to clinicians and policy makers. JAMA 2007; 298:221-224
    • (2007) JAMA , vol.298 , pp. 221-224
    • Detsky, A.S.1    Laupacis, A.2
  • 90
    • 0011124269 scopus 로고    scopus 로고
    • Anticipating a clinical investigator shortfall
    • Zisson S: Anticipating a clinical investigator shortfall. CenterWatch 2001; 8:1
    • (2001) CenterWatch , vol.8 , pp. 1
    • Zisson, S.1
  • 91
    • 1542614355 scopus 로고    scopus 로고
    • Campaign to revitalise academic medicine kicks off
    • Tugwell P: Campaign to revitalise academic medicine kicks off. BMJ 2004; 328:597
    • (2004) BMJ , vol.328 , pp. 597
    • Tugwell, P.1
  • 92
    • 30344434976 scopus 로고    scopus 로고
    • Academic and career development of pulmonary and critical care physician-scientists
    • Weinert CR, Billings J, Ryan R, et al: Academic and career development of pulmonary and critical care physician-scientists. Am J Respir Crit Care Med 2006; 173:23-31
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 23-31
    • Weinert, C.R.1    Billings, J.2    Ryan, R.3
  • 93
    • 67749087813 scopus 로고    scopus 로고
    • ICU research - One decade from
    • Fink MP, Suter PM, Sibbald WJ Eds, Berlin, Springer-Verlag
    • Marini JJ, Dries DJ: ICU research - One decade from now. In: Intensive Care Medicine in 10 Years. Fink MP, Suter PM, Sibbald WJ (Eds). Berlin, Springer-Verlag, 2006, pp 291-289
    • (2006) Intensive Care Medicine in 10 Years , pp. 291-289
    • Marini, J.J.1    Dries, D.J.2


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