Genetic correlation between autistic traits and IQ in a population-based sample of twins with autism spectrum disorders (ASDs) (Journal of Human Genetics (2009) 54, (56-61) DOI: 10.1038/jhg.2008.3);Genetic correlation between autistic traits and IQ in a population-based sample of twins with autism spectrum disorders (ASDs)

Journal of Human Genetics

Volumn 54, Issue 1, 2009, Pages 56-61

  Nishiyama, Takeshi ^a,b   Taniai, Hitomi ^c   Miyachi, Taishi ^d   Ozaki, Koken ^e   Tomita, Makoto ^f   Sumi, Satoshi ^g  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c Department of Pediatrics   (Japan)

^d Molecular Research Center for Children's Mental Development   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f NANZAN UNIVERSITY   (Japan)

^g Nagoya Western Rehabilitation Center for Children with Disabilities   (Japan)

Author keywords

Autistic spectrum disorders (ASDs); Cholesky structural equation model; Intelligence quotient (IQ); Nosology; Twin study

Indexed keywords

ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC PROCEDURES; GENETIC RISK; GENETIC SCREENING; GENETIC TRAIT; GENETIC VARIABILITY; HEREDITY; HUMAN; INTELLIGENCE QUOTIENT; JAPAN; MALE; PERSONAL EXPERIENCE; POPULATION BASED CASE CONTROL STUDY; PRESCHOOL CHILD; SEX DIFFERENCE; TWINS; BIOLOGICAL MODEL; GENETICS; INTELLIGENCE TEST; POPULATION GENETICS; QUANTITATIVE TRAIT;

AUTISTIC DISORDER; CHILD; FEMALE; GENETICS, POPULATION; HUMANS; INTELLIGENCE TESTS; MALE; MODELS, GENETIC; QUANTITATIVE TRAIT, HERITABLE; TWINS;

EID: 58849098086     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1038/jhg.2009.19     Document Type: Erratum

References (43)

1. Witwer, A. N. & Lecavalier, L. Examining the validity of autism spectrum disorder subtypes. J. Autism Dev. Disord. 38, 1611-1624 (2008).
2. Miles, J. H., Hadden, L. L., Takahashi, T. N. & Hillman, R. E. Head circumference is an independent clinical finding associated with autism. Am. J. Med. Genet. 95, 339-350 (2000).
3. Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J. et al. Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. J. Autism Dev. Disord. 36, 849-861 (2006).
4. Chakrabarti, S. & Fombonne, E. Pervasive developmental disorders in preschool children: confirmation of high prevalence. Am. J. Psychiatry 162, 1133-1141 (2005).
5. Strømme, P. & Diseth, T. H. Prevalence of psychiatric diagnoses in children with mental retardation: data from a population-based study. Dev. Med. Child Neurol. 42, 266-270 (2000).
6. Emerson, E. Prevalence of psychiatric disorders in children and adolescents with and without intellectual disability. J. Intellect. Disabil. Res. 47, 51-58 (2003).
7. Constantino, J. N. & Todd, R. D. Intergenerational transmission of subthreshold autistic traits in the general population. Biol. Psychiatry 57, 655-660 (2005).
8. Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E. et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol. Med. 25, 63-77 (1995).
9. Taniai, H., Nishiyama, T., Miyachi, T., Imaeda, M. & Sumi, S. Genetic influences on the broad spectrum of autism: study of proband-ascertained twins. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 147B, 844-849 (2008).
10. Spinath, F. M., Ronald, A., Harlaar, N., Price, T. S. & Plomin, R Phenotypic g early in life: On the etiology of general cognitive ability in a large population sample of twin children aged 2-4 years. Intelligence 31, 195-210 (2003).
11. Spinath, F. M., Harlaar, N., Ronald, A. & Plomin, R. Substantial genetic influence on mild mental impairment in early childhood. Am. J. Ment. Retard 109, 34-43 (2004).
12. Fombonne, E., Bolton, P., Prior, J., Jordan, H. & Rutter, M. A family study of autism: cognitive patterns and levels in parents and siblings. J. Child Psychol. Psychiatry 38, 667-683 (1997).
13. Folstein, S. E., Santangelo, S. L., Gilman, S. E., Piven, J., Landa, R., Lainhart, J. et al. Predictors of cognitive test patterns in autism families. J. Child. Psychol. Psychiatry 40, 1117-1128 (1999).
14. Spiker, D., Lotspeich, L. J., Dimiceli, S., Myers, R. M. & Risch, N. Behavioral phenotypic variation in autism multiplex families: evidence for a continuous severity gradient. Am. J. Med. Genet. 114, 129-136 (2002).
15. MacLean, J. E., Szatmari, P., Jones, M. B., Bryson, S. E., Mahoney, W. J., Bartolucci, G. et al. Familial factors influence level of functioning in pervasive developmental disorder. J. Am. Acad. Child. Adolesc. Psychiatry 38, 746-753 (1999).
16. Goin-Kochel, R. P., Mazefsky, C. A. & Riley, B. P. Level of functioning in autism spectrum disorders: phenotypic congruence among affected siblings. J. Autism. Dev. Disord 38, 1019-1027 (2008).
17. Sumi, S., Taniai, H., Miyachi, T. & Tanemura, M. Sibling risk of pervasive developmental disorder estimated by means of an epidemiologic survey in Nagoya, Japan. J. Hum. Genet. 51, 518-522 (2006).
18. Van Naarden Braun, K., Autry, A. & Boyle, C. A population-based study of the recurrence of developmental disabilities-Metropolitan Atlanta Developmental Disabilities Surveillance Program, 1991-94. Paediatr. Perinat. Epidemiol. 19, 69-79 (2005).
19. Ooki, S. & Asaka, A. Zygosity diagnosis in young twins by questionnaire for twins 'mothers and twins' self-reports. Twin Res 7, 5-12 (2004).
20. Schopler, E., Reichler, R. J., DeVellis, R. F. & Daly, K. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J. Autism Dev. Disord 10, 91-103 (1980).
21. Kurita, H., Miyake, Y. & Katsuno, K. Reliability and validity of the childhood autism rating scale-Tokyo version (CARS-TV). J. Autism Dev. Disord 19, 389-396 (1989).
22. Neale, M. C. & Cardon, L. R. Methodology for Genetics Studies of Twins and Families (Kluwer Academic Publishers: Boston, 1992).
23. Neale, M. C. Mx: Statistical Modeling, 5th edn. (Richmond, Virginia, 1999).
24. Wade, T., Neale, M. C., Lake, R. I. & Martin, N. G. A genetic analysis of the eating and attitudes associated with bulimia nervosa: dealing with the problem of ascertainment in twin studies. Behav. Genet 29, 1-10 (1999).
25. Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D. et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 368, 210-215 (2006).
26. R Development Core Team. R: A language and environment for statistical computing (R Foundation for Statistical Computing: Vienna, Austria, 2004).
27. Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J. et al. Structural variation of chromosomes in autism spectrum disorder. Am. J. Hum. Genet 82, 477-488 (2008).
28. Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T. et al. Strong association of de novo copy number mutations with autism. Science 316, 445-449 (2007).
29. Perry, A., Condillac, R. A., Freeman, N. L., Dunn-Geier, J. & Belair, J. Multi-site study of the Childhood Autism Rating Scale (CARS) in five clinical groups of young children. J. Autism Dev. Disord 35, 625-634 (2005).
30. Dawson, G., Estes, A., Munson, J., Schellenberg, G., Bernier, R. & Abbott, R. Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale. J. Autism Dev. Disord 37, 523-536 (2007).
31. Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L. et al. Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. J. Autism Dev. Disord. 33, 427-433 (2003).
32. Skuse, D. H., Mandy, W. P. & Scourfield, J. Measuring autistic traits: heritability, reliability and validity of the Social and Communication Disorders Checklist. Br. J. Psychiatry 187, 568-572 (2005).
33. Richler, J., Bishop, S. L., Kleinke, J. R. & Lord, C. Restricted and repetitive behaviors in young children with autism spectrum disorders. J. Autism Dev. Disord 37, 73-85 (2007).
34. Hus, V., Pickles, A., Cook##Jr, E. H., Risi, S. & Lord, C. Using the autism diagnostic interview-revised to increase phenotypic homogeneity in genetic studies of autism. Biol. Psychiatry 61, 438-448 (2007).
35. Joseph, R. M., Tager-Flusberg, H. & Lord, C. Cognitive profiles and social-communicative functioning in children with autism spectrum disorder. J. Child Psychol. Psychiatry 43, 807-821 (2002).
36. Shattuck, P. T. The contribution of diagnostic substitution to the growing administrative prevalence of autism in US special education. Pediatrics 117, 1028-1037 (2006).
37. Mahoney, W. J., Szatmari, P., MacLean, J. E., Bryson, S. E., Bartolucci, G., Walter, S. D. et al. Reliability and accuracy of differentiating pervasive developmental disorder subtypes. J. Am. Acad. Child Adolesc. Psychiatry 37, 278-285 (1998).
38. Tachimori, H., Osada, H. & Kurita, H. Childhood autism rating scale-Tokyo version for screening pervasive developmental disorders. Psychiatry Clin. Neurosci 57, 113-118 (2003).
39. Price, T. S., Dale, P. S. & Plomin, R. A longitudinal genetic analysis of low verbal and nonverbal cognitive abilities in early childhood. Twin Res 7, 139-148 (2004).
40. Casto, S. D., DeFries, J. C. & Fulker, D. W. Multivariate genetic analysis of Wechsler Intelligence Scale for Children-Revised (WISC-R) factors. Behav Genet 25, 25-32 (1995).
41. Knopik, V. S. & DeFries, J. C. A twin study of gender-influenced individual differences in general cognitive ability. Intelligence 26, 81-89 (1998).
42. Hallmayer, J., Glasson, E. J., Bower, C., Petterson, B., Croen, L., Grether, J. et al. On the twin risk in autism. Am. J. Hum. Genet 71, 941-946 (2002).
43. Ronalds, G. A., De Stavola, B. L. & Leon, D. A. The cognitive cost of being a twin: evidence from comparisons within families in the Aberdeen children of the 1950s cohort study. B.M.J. 331, 1306-1310 (2005).