The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype

Annals of the Rheumatic Diseases

Volumn 68, Issue 2, 2009, Pages 253-256

  Rueda, B ^a   Broen, J ^b   Torres, O ^a   Simeon, C ^c   Ortego Centeno, N ^d   Schrijvenaars, M M V A P ^b   Vonk, M C ^b   Fonollosa, V ^c   Van Den Hoogen, F H J ^e   Coenen, M J H ^b   Sanchez Roman J ^f   Aguirre Zamorano, M A ^g   Garcia Portales R ^h   Pros, A ⁱ   Camps, M T ^j   Gonzalez Gay, M A ^k   Martin, J ^a   Radstake, T R D J ^b,l  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Servicio de Medinina Interna   (Spain)

^d HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^e SINT MAARTENSKLINIEK   (Netherlands)

^f HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^g HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^h HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

ⁱ HOSPITAL DEL MAR   (Spain)

^j HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^k HOSPITAL XERAL CALDE   (Spain)

^l BOSTON MEDICAL CENTER   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC SCLEROSIS;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN; SCLERODERMA, SYSTEMIC;

EID: 58849088955     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2008.096719     Document Type: Article

References (17)

1. Jimenez SA, Derk CT. Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med 2004;140:37- 50
2. Del Galdo F, Artlett CM. T cells and B cells in the pathogenesis of systemic sclerosis: recent insights and therapeutic opportunities Curr Rheumatol Rep 2006;8:123-30.
3. Bettelli E, Oukka M, Kuchroo VK T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007;8:345-50
4. Langrish CL, Chen Y, Blumenschein WM, Mattson J. Basham B, Sedgwick JD, et al IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 2005;201:233-40.
5. Kurasawa K, Hirose K, Sano H, Endo H, Shinkai H, Nawata Y. et al. Increased interleukin-17 levels in patients with systemic sclerosis Arthritis Rheum 2000;43:2455-63.
6. Murata M, Fujimoto M, Matsushita T. Hamaguchi Y, Hasegawa M. Takehara K. et al Clinical association of serum interleukin-17 levels in systemic sclerosis Is systemic sclerosis a Th17 disease? J Dermatol Sci 2008;50:240-2
7. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL lnterleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleuKin-17 J Biol Chem 2003;278:1910-4
8. Komura K, Fujimoto M, Hasegawa M. Ogawa F, Hara T, Muroi E. et al. Increaseo serum interleukin 23 in patients with systemic sclerosis. J Rheumatol 2007;35:120-5
9. Duerr RH, Taylor KD, Brant SR. Rioux JD, Silverberg MS. Daly MJ, et al A genome- wide association study identifies IL23R as an inflammatory bowel disease gene Science 2006;314:1461-3.
10. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al Association scan of 14, 500 nonsynonyrnous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39:1329-37.
11. Rueda B, Orozco G, Raya E, Fernandez-Sueiro JL, Mulero J, Blanco FJ, et al. The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis. Ann Rheum Dis 2008;67:1451-4
12. LeRoy EC, Black C, Fleischmajet R, Jablonska S, Kneg T. Medsger TA Jr. et al Scleroderma (systemic sclerosis): classification. subsets and pathogenesis J Rheumatol 1988;15:202-5.
13. Matucci-Cerinic M. D'Angelo S. Denton CP. Vlachoyiannopoulos P. Silver R Assessment of lung involvement. Clin Exp Rheumatol 2003;21:S19-23
14. Farago B, Magyari L, Safrany E, Csongei V, Jaromi L, Horvatovich K, et al Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis Out not for systemic sclerosis. Ann Rheum Dis 2008;67:248-50.
15. Orozco G, Rueda B, Robledo G, Garcia A. Martin J Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort. Hum Immunol 2007;68:681-4
16. Sanchez E, Rueda B, Callejas JL, Sabio JM, Ortego-Centeno N, Jimenez-Alonso J. et al. Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus. Tissue Antigens 2007;70:233-7.
17. Evans HG, Suddason T, Jackson I, Taarns LS, Lord GM Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor activated monocytes Proc Natl Acad So USA 2007;104:17034-9