Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab′ fragment (99mTc-DI-DD3B6/22-80B3): Results of a phase I trial

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 36, Issue 2, 2009, Pages 250-259

  Macfarlane, David ^a   Socrates, Angelides ^b,c   Eisenberg, Paul ^d   Larcos, George ^b,c   Roach, Paul ^b,e   Gerometta, Michael ^f   Smart, Richard ^g,h   Tsui, Wendy ^g,h   Scott, Andrew M ^i,j  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c WESTMEAD HOSPITAL   (Australia)

^d AMGEN INC   (United States)

^e ROYAL NORTH SHORE HOSPITAL   (Australia)

^f Agen Biomedical Pty Ltd   (Australia)

^g ST GEORGE HOSPITAL   (Australia)

^h UNIVERSITY OF NEW SOUTH WALES   (Australia)

ⁱ AUSTIN HOSPITAL   (Australia)

^j OLIVIA NEWTON JOHN CANCER RESEARCH INSTITUTE   (Australia)

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Author keywords

Molecular imaging; Pulmonary embolism; Radiolabelled proteins peptides; Technetium chemistry; Technetium radiopharmaceuticals

Indexed keywords

D DIMER; DI 80B3 TC 99M FAB'; IMMUNOGLOBULIN F(AB) FRAGMENT; THROMBOVIEW; TRACER; UNCLASSIFIED DRUG;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIBODY LABELING; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DEEP VEIN THROMBOSIS; DOSIMETRY; DRUG DISTRIBUTION; DRUG DOSE ESCALATION; DRUG SAFETY; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYPERTENSION; IMMUNOGENICITY; LACTATE DEHYDROGENASE BLOOD LEVEL; LUNG EMBOLISM; MALE; MOLECULAR IMAGING; MULTICENTER STUDY; OPEN STUDY; PHASE 1 CLINICAL TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STATISTICAL ANALYSIS; VOLUNTEER; WHOLE BODY SCINTISCANNING;

ADULT; AGED; FEMALE; FIBRIN; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOGLOBULIN FAB FRAGMENTS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RADIOMETRY; SAFETY; STAINING AND LABELING; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VENOUS THROMBOSIS;

EID: 58849085447     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-008-0934-7     Document Type: Article

References (23)

1. J Douketis C Kearon S Bates EK Duku JS Ginsberg 1998 Risk of fatal pulmonary embolism in patients with treated venous thromboembolism JAMA 279 458 462
2. C Tovey S Wyatt 2003 Diagnosis, investigation, and management of deep vein thrombosis BMJ 326 1180 1184
3. MD Silverstein JA Heit DN Mohr TM Petterson WM O'Fallon LJ Melton 1998 Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population based study Arch Intern Med 158 585 593
4. RH White 2003 The epidemiology of venous thromboembolism Circulation 107 Suppl 1 I4 8
5. SM Bates JS Ginsberg 2004 Treatment of deep-vein thrombosis N Engl J Med 351 268 277
6. C Kearon JA Julian JS Ginsberg 1998 Noninvasive diagnosis of deep vein thrombosis. McMaster Diagnostic Imaging Practice Guidelines Initiative Ann Intern Med 128 663 677
7. C Kearon 2003 Diagnosis of pulmonary embolism CMAJ 168 183 194
8. R Lisbona V Derbekyan JA Novales-Diaz CL Rush 1985 Tc-99m red blood cell venography in deep venous thrombosis of the lower limb: an overview Clin Nucl Med 10 208 224
9. J Lister-James LC Knight AH Maurer LR Bush BR Moyer RT Dean 1996 Thrombus imaging with a technetium-99 m-labeled, activated platelet receptor-binding peptide J Nucl Med 37 775 781
10. DB Rylatt AS Blake LE Cottis DA Massingham WA Fletcher PP Masci 1983 An immunoassay for human D dimer using monoclonal antibodies Thromb Res 31 767 778
11. KZ Walker LJ Milner GJ Bautovich P Borham AK Wood DB Rylatt 1990 Detection of experimental thrombi in rabbits with an I-labeled fibrin-specific monoclonal antibody Eur J Nucl Med 16 787 794
12. KZ Walker GR Boniface AF Phippard W Harewood GJ Bautovich PG Bundesen 1991 Preclinical evaluation of 99m-technetium-labeled DD-3B6/22 Fab′ for thrombus detection Thromb Res 64 691 701
13. G Bautovich S Angelides FT Lee R Greenough P Bundesen P Murray 1994 Detection of deep venous thrombi and pulmonary embolus with technetium-99m-DD- 3B6/22 antifibrin monoclonal antibody Fab′ fragment J Nucl Med 35 195 202
14. TA Morris JJ Marsh PG Chiles RG Konopka CA Pedersen PF Schmidt 2004 Single photon emission computed tomography of pulmonary emboli and venous thrombi using anti-Ddimer Am J Respir Crit Care Med 169 987 993
15. JA Siegel SR Thomas JB Stubbs MG Stabin MT Hays KF Koral 1999 MIRD pamphlet no. 16: techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates J Nucl Med 40 Suppl 37 61
16. E McKay 2003 A software tool for specifying voxel models for dosimetry estimation Cancer Biother Radiopharm 18 379 392
17. 99mTc-DI-DD-3B6/22-80B3 Fab′ Eur J Nucl Med Mol Imaging 33 6 648 656
18. MG Stabin 1996 MIRDOSE: personal computer software for internal dose assessment in nuclear medicine J Nucl Med 37 538 546
19. G Sgouros 1993 Bone marrow dosimetry for radioimmunotherapy: theoretical considerations J Nucl Med 34 689 694
20. S Shen GL DeNardo G Sgouros RT O'Donnell SJ DeNardo 1999 Practical determination of patient-specific marrow dose using radioactivity concentration in blood and body J Nucl Med 40 2102 2106
21. R Temple 2006 Hy's law: predicting serious hepatotoxicity Pharmacoepidemiol Drug Saf 15 4 241 243
22. MK Carlson PP Gleason S Sen 2001 Elevation of hepatic transaminases after enoxaparin use: case report and review of unfractionated and low-molecular-weight heparin-induced hepatotoxicity Pharmacotherapy 21 1 108 113
23. M Meignan J Rosso H Gauthier F Brunengo S Claudel L Sagnard P d'Azemar G Simonneau B Charbonnier 2000 Systematic lung scans reveal a high frequency of silent pulmonary embolism in patients with proximal deep venous thrombosis Arch Intern Med 160 2 159 164