Single photon emission computed tomography of pulmonary emboli and venous thrombi using anti-d-dimer

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 9, 2004, Pages 987-993

  Morris, Timothy A ^a   Marsh, James J ^b   Chiles, Peter G ^b   Konopka, Ronald G ^b   Pedersen, Craig A ^b   Schmidt, Peter F ^b   Gerometta, Michael ^b  

^a UCSD MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

D DIMER; FIBRIN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; RHESUS D ANTIBODY; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEEP VEIN THROMBOSIS; DIAGNOSTIC ACCURACY; DOG; ENERGY YIELD; EXPERIMENTAL TEST; FEASIBILITY STUDY; FORELIMB; IMAGE ANALYSIS; IMAGING SYSTEM; IMMUNIZATION; INFUSION; INJECTION; ISOTOPE LABELING; LEG; LUNG EMBOLISM; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RELIABILITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TECHNIQUE; THORAX; VENOUS THROMBOEMBOLISM;

EID: 2142763878     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200306-735oc     Document Type: Article

References (27)

1. Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJR. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based sludy. Arch Intern Med 1998;158:585-593.
2. PIOPED Investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED). JAMA 1990;263:2753-2759.
3. Perrier A, Howarth N, Didier D, Loubeyre P, Unger PF, de Moerloose P, Slosman D, Junod A, Bounameaux H. Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism. Ann Intern Med 2001;135:88-97.
4. Gillies TE, Ruckley CV, Nixon SJ. Still missing the boat with fatal pulmonary embolism. Br J Surg 1996;83:1394-1395.
5. Morgenthaler TI, Ryu JH. Clinical characteristics of fatal pulmonary embolism in a referral hospital. Mayo Clin Proc 1995;70:417-424.
6. Rubinstein I, Murray D, Hoffstein V. Fatal pulmonary emboli in hospitalized patients: an autopsy study. Arch Intern Med 1988;148:1425-1426.
7. Douketis JD, Kearon C, Bates S, Duku EK, Ginsberg JS. Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. JAMA 1998;279:458-462.
8. Lusiani L, Zanco P, Visona A, Breggion G, Pagnan A, Ferlin G. Immunoscintigraphic detection of venous thrombosis of the lower extremities by means of human anitfibrin monoclonal antibodies labeled with In-111. Angiology 1989;40:671-677.
9. Jung M, Kletter K, Dudczak R, Koppensteiner R, Minar E, Kahls P, Stumpflen A, Pokieser P, Ehringer H. Deep vein thrombosis: scintigraphic diagnosis with 1n-111-labeled monoclonal antifibrin antibodies. Radiology 1989;173:469-475.
10. Schaible TF, Alavi A. Antifibrin scintigraphy in the diagnostic evaluation of acute deep venous thrombosis. Semin Nucl Med 1991;21:313-324.
11. Morris TA, Marsh JJ, Fagnani R, Hagan M, Moser KM. Degree of polymer organization decreases the binding of a monoclonal antibody raised against the beta-chain amino terminus of fibrin. Thromb Haemost 1997:77:704-709.
12. Hyers TM, Agnelli G, Hull RD, Morris TA, Samama M, Tapson V, Weg JG. Antithrombotic therapy for venous thromboembolic disease. Chest 2001;119(1 Suppl):176S-193S.
13. Morris TA, Marsh JJ, Konopka R, Pedersen CA, Chiles PG, Fagnani R, Hagan M, Moser KM. Antibodies against the fibrin beta-chain aminoterminus detect active canine venous thrombi. Circulation 1997;96:3173-3179.
14. Morris TA, Marsh JJ, Konopka R, Pedersen CA, Chiles PG. Anti-thrombotic efficacies of enoxaparin, dalteparin, and unfractionated heparin in venous thrombo-embolism. Thromb Res 2000;100:185-194.
15. Morris TA, Pedersen CA, Konopka RG, Chiles PG, Marsh JJ. SPECT scan images of pulmonary emboli using radiolabeled antibodies [abstract]. Am J Respir Crit Care Med 2001;163:A198.
16. Rylatt DB, Blake AS, Cottis LE, Massingham DA, Fletcher WA, Masci PP, Whitaker AN, Elms M, Bunce I, Webber AJ. An immunoassay for human D dimer using monoclonal antibodies. Thromb Res 1983;31:767-778.
17. Lamoyi E, Nisonoff A, Preparation of F(ab')2 fragments from mouse IgG of various subclasses. J Immunol Methods 1983;56:235-243.
18. Lee FT, Milner LJ, Boniface GR, Bautovich GJ, Weedon AR, Bundesen PG, Rylatt DB, Walker KZ. Evaluation of thrombus detection in a rabbit model using a technetium-99m-labelled anti-librin monoclonal antibody. Immunol Cell Biol 1992;70:173-179.
19. Lee FT, Boniface GR, Lambrecht RM, Rylatt DB, Bundesen PG. Technetium-99 m labelling of DD-3B6/22 antifibrin monoclonal antibody fragment Fab' for thrombus imaging. Immunol Cell Biol 1993;71:117-124.
20. Marsh JJ, Konopka RG, Lang IM, Wang HY, Pedersen C, Chiles P, Reilly CF, Moser KM. Suppression of thrombolysis in a canine model of pulmonary embolism. Circulation 1994;90:3091-3097.
21. Tapson VF, Carroll BA, Davidson BL, Elliott CG, Fedullo PF, Hales CA, Hull RD, Hyers TM, Leeper KJ, Morris TA, et al. The diagnostic approach to acute venous thromboembolism: clinical practice guideline: American Thoracic Society. Am J Respir Crit Care Med 1999;160:1043-1066.
22. Mountain A, Adair JR. Engineering antibodies for therapy. Biotechnol Genet Eng Rev 1992;10:1-142.
23. Madsen MT, Kirchner PT, Grover-McKay M, Aktay R, Seahold JS, Rezai K, Kelly G. Emission-based attenuation correction of myocardial perfusion studies. J Nucl Cardiol 1997;4:477-486.
24. Wallis JW, Miller TR, Koppel P. Attenuation correction in cardiac SPECT without a transmission measurement. J Nucl Med 1995;36:506-512.
25. Girard P, Decousus M, Laporte S, Buchmuller A, Herve P, Lamer C, Parent F, Tardy B. Diagnosis of pulmonary embolism in patients with proximal deep vein thrombosis: specificity of symptoms and perfusion defects at baseline and during anticoagulant therapy. Am J Respir Crit Care Med 2001;164:1033-1037.
26. Hull RD, Raskob GE, Ginsberg JS, Panju AA, Brill-Edwards P, Coates G, Pineo GF. A noninvasive strategy for the treatment of patients with suspected pulmonary embolism. Arch Intern Med 1994;154:289-297.
27. Moser KM, Fedullo PF, Littejohn JK, Crawford R. Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis [published erratum appears in JAMA 1994;271:1908]. JAMA 1994;271:223-225.