Uptake of 99mTc-labeled chondroitin sulfate by chondrocytes and cartilage: a promising agent for imaging of cartilage degeneration?

Nuclear Medicine and Biology

Volumn 36, Issue 1, 2009, Pages 65-71

  Sobal, Grazyna ^a   Menzel, Johannes ^b   Sinzinger, Helmut ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Autoradiography; Chondroitin sulfate; Osteoarthritis; Uptake

Indexed keywords

CHONDROITIN SULFATE; CHONDROITIN SULFATE TC 99M; DRUG ADDITIVE; HYALURONIDASE; MAGNESIUM STEARATE; PHOSPHATE BUFFERED SALINE; PROTEOGLYCAN; TECHNETIUM 99M; TRACER; UNCLASSIFIED DRUG; HYALURONOGLUCOSAMINIDASE; TECHNETIUM COMPLEX;

ARTICLE; AUTORADIOGRAPHY; CARTILAGE DEGENERATION; CELL SUSPENSION; CONTROLLED STUDY; DRUG INDICATION; DRUG UPTAKE; FROZEN SECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; ISOTOPE LABELING; MONOLAYER CULTURE; OSTEOARTHRITIS; PROTEOGLYCAN SYNTHESIS; RIB CARTILAGE; AGED; CARTILAGE; CARTILAGE CELL; CELL CULTURE; CHEMISTRY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; STAINING;

AGED; AUTORADIOGRAPHY; CARTILAGE; CELLS, CULTURED; CHONDROCYTES; CHONDROITIN SULFATES; HUMANS; HYALURONOGLUCOSAMINIDASE; MALE; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; STAINING AND LABELING;

EID: 58749112926     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2008.10.013     Document Type: Article

References (20)

1. Hardingham T.E., and Fosang A.J. Proteoglycans, many forms, many functions. FASEB J 6 (1992) 861-870
2. Palmer W.E., Schoenberg O.I., Fischman A.J., Rosenthall D.I., and Polisson R.P. FDG metabolism in the wrist during treatment of inflammatory arthritis: Quantitation with PET and correlation with clinical response (abstr.). J Nucl Med 35 (1994) 45P
3. Bourgeois P., Chales G., Dehais J., Delcambre B., Kuntz J.L., and Rozenberg S. Efficacy and tolerability of chondroitin sulfate 1200 mg per day vs. 3×400 mg per day vs. placebo. Osteoarthritis Cartilage 6 (1998) 25-30
4. Ronca F., Palmieri L., Pinicucci P., and Ronca G. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 6SA (1998) 14-21
5. Uebelhart D., Thonar E.J.M.A., Delmas P.D., Chantraine A., and Vignon E. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis, a pilot study. Osteoarthritis Cartilage 6 (1998) 39-46
6. Uebelhart D., Thonar E.J.M.A., Zhang J., and Williams J.M. Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit. Osteoarthritis Cartilage 6 (1998) 6-13
7. Palmieri L., Conte A., Giovannini L., Lualdi P., and Ronca G. Metabolic fate of exogenous chondroitin sulfate in the experimental animal. Arzneimittel Forsch Drug Res 40 (1990) 319-323
8. Ishihara M., Fedarko N.S., and Conrad H.E. Involvement of phosphatidylinositol and insulin in the coordinate regulation of proteoheparan sulfate metabolism and hepatocyte growth. J Biol Chem 262 (1987) 4708-4716
9. Weinstein T., Gafter U., Chagnac A., and Skutelsky E. Distribution of glycosaminoglycans in rat tubular epithelium. J Am Soc Nephrol 4 (1997) 586-595
10. 99mTc et scintigraphie du cartilage. Isot Radioact Clin Rech 12 (1976) 183-190
11. Sobal G., Menzel E.J., and Sinzinger H. Radiolabeling procedure, quality control and stability of (99m)Tc-labeled chondroitin sulfate: A new approach of targeting osteoarthritis. Appl Radiat Isot 66 (2008) 415-420
12. 125I) LDL on macrophages. J Recept Signal Transduct Res 22 (2002) 459-470
13. Camejo G., Rosengren B., Olson U., Lopez F., Olofson S.O., Westerlund C., and Bondjers G. Molecular basis of the association of arterial proteoglycans with low density lipoproteins. Its effect on the structure of the lipoprotein particle. Eur Heart J 11 Suppl. E (1990) 164-173
14. Kaplan M., and Aviram M. Macrophage plasma membrane chondroitin sulfate proteoglycan binds oxidized low-density lipoprotein. Atherosclerosis 149 (2000) 5-17
15. Fujimoto T., Kawashima H., Tanaka T., Hirose M., Toyama-Sorimachi N., Matsuzawa Y., et al. CD44 binds a chondroitin sulfate proteoglycan, aggrecan. Int Immunol 13 (2001) 359-366
16. Blanco F.J., Guitian R., Vazquez-Martul E., de Toro F.J., and Galdo F. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41 (1998) 259-284
17. Hashimoto S., Takahashi K., Amiel D., Coutts R.D., and Lotz M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 41 (1998) 1266-1274
18. Rediske J.J., Koehne C.F., Zhang B., and Lotz M. The inducible production of nitric oxide by articular cell types. Osteoarthritis Cartilage 2 (1994) 199-206
19. Stadler J., Stefanovic-Racic M., Billiar T.R., Curran R.D., McIntyre L.A., Georgescu H.I., et al. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 147 (1991) 3915-3920
20. Chen A.F., Davies C.M., De Lin M., and Fermor B. Oxidative DNA damage in osteoarthritic porcine articular cartilage. J Cell Physiol (2008) [Epub ahead of print]