Skin homing of Treponema pallidum in early syphilis: An immunohistochemical study

Applied Immunohistochemistry and Molecular Morphology

Volumn 17, Issue 1, 2009, Pages 47-50

  Quatresooz, Pascale ^a   Piérard, Gérald E ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Spirochete homing; Syphilis; Treponema pallidum

Indexed keywords

BACTERIUM ANTIBODY; DIAGNOSTIC AGENT;

ARTICLE; BORRELIA INFECTION; CONTROLLED STUDY; DERMIS; EPIDERMIS; HISTOCHEMISTRY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LICHENOID ERUPTION; MICROBIAL IDENTIFICATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEROLOGY; SILVER STAINING; SKIN BIOPSY; SYPHILIS; TREPONEMA PALLIDUM; BORRELIA; FEMALE; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY;

ANTIBODIES, BACTERIAL; BORRELIA; EPIDERMIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SYPHILIS; SYPHILIS, CUTANEOUS; TREPONEMA PALLIDUM;

EID: 58749111504     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e3181788186     Document Type: Article

References (34)

1. Hutchinson CM, Hook EW, Shepherd M, et al. Altered clinical presentation of early syphilis in patients with HIV infection. Ann Intern Med. 1994;121:94-100.
2. Giard M, Queyron PC, Ritter J, et al. The recent increase of syphilis cases in Lyon University hospitals is mainly observed in HIVinfected patients: descriptive data from a laboratory-based surveillance system. J Acquir Immun Defic Syndr. 2003;34:441-443. (Pubitemid 37444475)
3. Brown AE, Sadler KE, Tomkins SE, et al. Recent trends in HIV and other STIs in the United Kingdom: data to the end of 2002. Sex Transm Infect. 2004;80:159-166.
4. Grassly NC, Fraser C, Garnett GP. Host immunity and synchronized epidemics of syphilis across the United States. Nature. 2005;433:417-421. (Pubitemid 40203321)
5. Alessi E, Innocenti M, Ragusa G. Secondary syphilis: clinical morphology and histopathology. Am J Dermatopathol. 1983;5: 11-17. (Pubitemid 13132760)
6. Jordaan HF. Secondary syphilis. A clinicopathologic study. Am J Dermatopathol. 1988;10:399-409.
7. Engelkens HJH, Ten Kate FJW, Judanarso J, et al. The localization of treponemes and characterization of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious jaws. Genitourin Med. 1993;69:102-107. (Pubitemid 23128265)
8. Beckett JH, Bigbee JW. Immunoperoxidase localization of Treponema pallidum: its use in formaldehyde-fixed and paraffin embedded tissue sections. Arch Pathol Lab Med. 1979;103: 135-138.
9. Lee WS, Lee MG, Chung KY, et al. Detection of Treponema pallidum in tissue: a comparative study of the avidin-biotinperoxidase complex, indirect immunoperoxidase, FTA-ABS complement techniques and darkfield method. Yonsei Med J. 1991;32: 335-339.
10. Phelps RG, Knispel J, Tu ES, et al. Immunoperoxidase technique for detecting spirochetes in tissue sections: comparison with other methods. Int J Dermatol. 2000;39:609-613. (Pubitemid 30686137)
11. Hoang MP, High WA, Molberg KH. Secondary syphilis: a histologic and immunohistochemical evaluation. J Cutan Pathol. 2004;31:595-599.
12. Quatresooz P, Blaise G, Piérard-Franchimont C, et al. La syphilis, la grande simulatrice démasquée. Dermatol Actual. 2007;104: 6-10.
13. Chesson HW, Dee TS, Aral SO. AIDS mortality may have contributed to the decline in syphilis rates in the United States in the 1990s. Sex Transm Dis. 2003;30:419-424.
14. Poulton M, Dean GL, Williams DI, et al. Surfing with spirochetes: an ongoing syphilis outbreak in Brighton. Sex Transm Infect. 2001; 77:319-321. (Pubitemid 32964262)
15. Fenton KA, Lowndes CM. Recent trends in the epidemiology of sexually transmitted infections in the European Union. Sex Transm Infect. 2004;80:255-263. (Pubitemid 39070785)
16. White C. Sexually transmitted diseases continue to rise. Br Med J. 2004;329:249.
17. Lautenschlager S. Sexually transmitted infections in Switzerland: return of the classics. Dermatology. 2005;210:134-142. (Pubitemid 40463203)
18. Peterman TA, Heffelfinger JD, Swint EB, et al. The changing epidemiology of syphilis. Sex Transm Dis. 2005;32:S4-S10.
19. Flagothier C, Arrese JE, Piérard-Franchimont C, et al. Syphilis: une MST de retour en nos murs. Rev Med Liége. 2004;59:426-429.
20. Frauenfelder C. Incidence of syphilis in UK rises as HIV diagnoses hold steady. Br Med J. 2006;333:1089.
21. Abraham S, Toutous-Trellu L, Pechère M, et al. Increased incidence of sexually transmitted infections in Geneva, Switzerland. Dermatology. 2006;212:41-46.
22. Kerani RP, Handsfield HH, Stenger MS, et al. Rising rates of syphilis in the era of syphilis elimination. Sex Transm Dis. 2007;34: 154-161.
23. Tang MGY, Yosipovitch G, Tan SH. Secondary syphilis presenting as a lichen planus-like rash. J Eur Acad Dermatol Venereol. 2004;18: 185-187. (Pubitemid 38379898)
24. Lautenschlager S. Cutaneous manifestations of syphilis. Recognition and management. Am J Clin Dermatol. 2006;7:291-304. (Pubitemid 46998579)
25. Lautenschlager S, Schwarzkopf S, Borelli S. Presternal indurated ulceration: primary syphilis. Dermatology. 2006;212:200-202. (Pubitemid 43260738)
26. Dang O, Feng J, Lu X, et al. Evaluation of specific antibodies for early diagnosis and management of syphilis. Int J Dermatol. 2006; 45:1169-1171. (Pubitemid 44560364)
27. Leslie DE, Azzato F, Karapanagiotidis T, et al. Development of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing. J Clin Microbiol. 2007;45:93-96. (Pubitemid 46106412)
28. Cummings MC, Lukehart SA, Marra C, et al. Comparison of methods for the detection of Treponema pallidum in lesions of early syphilis. Sex Transm Dis. 1996;23:366-369. (Pubitemid 26313844)
29. Backhouse JL, Nesteroff SI. Treponema pallidum western blot: comparison with the FTA-ABS test as a confirmatory test for syphilis. Diag Microbiol Inf Dis. 2001;39:9-14.
30. Palmer HM, Higgins SP, Herring AJ, et al. Use of PCR in the diagnosis of early syphilis in the United Kingdom. Sex Transm Infect. 2003;79:479-483.
31. Wenhai L, Jianzhong Z, Cao Y. Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate. Dermatology. 2004;208:94-97. (Pubitemid 38446004)
32. Koek AG, Bruisten SM, Dierdorp M, et al. Specific and sensitive diagnosis of syphilis using a real-time PCR for Treponema pallidum. Clin Microbiol Infect. 2006;12:1233-1236. (Pubitemid 44762529)
33. Morshed MG, Lee MK, Jorgensen D, et al. Molecular methods used in clinical laboratory: prospects and pitfalls. FEMS Immunol Med Microbiol. 2007;49:184-191. (Pubitemid 46257132)
34. Arrese Estrada J, Melotte P, Hermanns JF, et al. Identification immunohistochimique des spirochètes de type Borrelia. Ann Dermatol Venereol. 1991;118:277-279.