Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation

Anesthesia and Analgesia

Volumn 108, Issue 1, 2009, Pages 382-

  Shah, Ajit ^a   Mistry, Bipin ^c   Gibiansky, Ekaterina ^c   Gibiansky, Leonid ^b  

^a GUILFORD PHARMACEUTICALS INC   (United States)

^b QuantPharm LLC 49 Flints Grove Drive   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; FOSPROPOFOL; PROPOFOL; VANADATE SODIUM; DRUG DERIVATIVE; INTRAVENOUS ANESTHETIC AGENT; PRODRUG; VANADIC ACID;

BLOOD PH; BLOOD SAMPLING; DIAGNOSTIC ERROR; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG METABOLISM; FOOD AND DRUG ADMINISTRATION; HEMOLYSIS; HUMAN; LETTER; PRIORITY JOURNAL; SEDATION; ANIMAL; BIOASSAY; BIOTRANSFORMATION; BLOOD; CHEMISTRY; DRUG STABILITY; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; PH; REPRODUCIBILITY; SOLUBILITY;

ANESTHETICS, INTRAVENOUS; ANIMALS; BIOLOGICAL ASSAY; BIOTRANSFORMATION; DRUG STABILITY; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; PRODRUGS; PROPOFOL; REPRODUCIBILITY OF RESULTS; SOLUBILITY; VANADATES;

EID: 58749111302     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31818ce924     Document Type: Letter

References (6)

1. Fechner J, Ihmsen H, Hatterscheid D, Schiessl C, Vornov JJ, Burak E, Schwilden H, Schuttler J. Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers. Anesthesiology 2003;99:303-13
2. Fechner J, Ihmsen H, Hatterscheid D, Jeleazcov C, Schiessl C, Vornov JJ, Schwilden H, Schuttler J. Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion. Anesthesiology 2004;101:626 -39
3. Struys MM, Vanluchene AL, Gibiansky E, Gibiansky L, Vornov J, Mortier EP, Van Bortel L. AQUAVAN, a water-soluble prodrug of propofol as a bolus injection: a phase I dose escalation comparison with DIPRIVAN. Part II: pharmacodynamics and safety. Anesthesiology 2005;103: 730-43
4. Gibiansky E, Struys M, Gibiansky L, Vanluchene AL, Vornov J, Mortier EP, Burak E, Van Bortel L. AQUAVAN Injection, a water-soluble prodrug of propofol as bolus injection: a phase I dose escalation comparison with DIPRIVAN. Part 1: pharmacokinetics. Anesthesiology 2005; 103:718-29
5. Schywalsky M, Ihmsen H, Tzabazis A, Fechner J, Burak E, Vornov J, Schwilden H. Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats. Eur J Anaesthesiol 2003;20:182-90
6. Fechner J, Ihmsen H, Schiessl C, Jeleazcov C, Vornov JJ, Schwilden H, Schuttler J. Sedation with GPI 15715, a water-soluble prodrug of propofol, using targetcontrolled infusion in volunteers. Anesth Analg 2005;100:701-6 DOI: 10.1213/ane.0b013e31818ce924