Enhanced expression of Hab18g/CD147 and activation of integrin pathway in HCC cells under 3-D co-culture conditions

Cell Biology International

Volumn 33, Issue 2, 2009, Pages 199-206

  Wu, Ya Mei ^a   Tang, Juan ^a   Zhao, Pu ^a   Chen, Zhi Nan ^a   Jiang, Jian Li ^a  

^a Cell Engineering Research Centre   (China)

Author keywords

3 Dimensional culture; Adhesion molecules; Extracellular matrix; HAb18G CD147; Tumor stroma interaction

Indexed keywords

CD147 ANTIGEN; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; INTEGRIN; PAXILLIN;

ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; CANCER INVASION; CARCINOMA CELL; CELL ADHESION; CELL FUNCTION; COCULTURE; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; FIBROBLAST; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; METASTASIS; PHENOTYPE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR CELL;

ADULT; ANTIGENS, CD147; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL CULTURE TECHNIQUES; FIBROBLASTS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTEGRINS; LIVER NEOPLASMS; MALE; MATRIX METALLOPROTEINASES; PAXILLIN; TUMOR CELLS, CULTURED;

EID: 58749096876     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2008.11.006     Document Type: Article

References (31)

1. Berditchevski F., Chang S., Bodorova J., and Hemler M.E. Generation of monoclonal antibodies to integrin-associated proteins. J Biol Chem 272 (1997) 29174-29180
2. Bhowmick N.A., and Moses H.L. Tumor-stroma interactions. Curr Opin Genet Dev 15 (2005) 97-101
3. Biswas C., Zhang Y., DeCastro R., Guo H., Nakamura T., Kataoka H., et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res 55 (1995) 434-439
4. Brown M.C., and Turner C.E. Paxillin: adapting to change: review article. Physiol Rev 84 (2004) 1315-1339
5. Brown M.C., West K.A., and Turner C.E. Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell 13 (2002) 1550-1565
6. Caudroy S., Polette M., Nawrocki-Raby B., Cao J., Toole B.P., Zucker S., et al. EMMPRIN-mediated MMP regulation in tumor and endothelial cells. Clin Exp Metastasis 19 (2002) 697-702
7. Chen ZN, Shang P, Li Y, Qian AR, Zhu P, Xing JL, inventors; NTD patent & trademark agency Ltd., Beijing office, assignee. HAb18G/CD147, its agonist and application. Chinese patent ZL01131735.3, 2001 September 28; PCT international patent WO02/094875.2002 May 27.
8. Chen ZN, Xing JL, Zhang SH, inventors; NTD patent & trademark agency Ltd., Beijing office, assignee. Anti-human hepatoma monoclonal antibody HAb18 light/heavy chain variable region gene, and use thereof. Chinese patent ZL02114471.0, 2002 March 15; PCT international patent WO03/078469, 2003 March 17.
9. Cukierman E., Pankov R., Stevens D.R., and Yamada K.M. Taking cell-matrix adhesions to the third dimension. Science 294 (2001) 1708-1712
10. Curtin K.D., Meinertzhagen I.A., and Wyman R.J. Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci 118 (2005) 2649-2660
11. Fadool J.M., and Linser P.J. Evidence for the formation of multimeric forms of the 5A11/HT7 antigen. Biochem Biolphys Res Commun 229 (1996) 280-286
12. Fossum S., Mallett S., and Barclay A.N. The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence. Eur J Immunol 21 (1991) 671-679
13. Gabison E.E., Hoang-Xuan T., Mauviel A., and Menashi S. EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie 87 (2005) 361-368
14. Kim J.B. 3-Dimensional tissue culture models in cancer biology. Semin Cancer Biol 15 (2005) 365-377
15. Kuphal S., Bauer R., and Bosserhoff A.K. Integrin signaling in malignant melanoma. Cancer Metastasis Rev 24 (2005) 195-222
16. Liotta L.A., and Kohn E.C. The microenvironment of the tumour-host interface. Nature 411 (2001) 375-379
17. Liu Y.F., Chen Z.N., and Ji Y.Y. Localization of hepatocellular carcinoma with monoclonal antibodies. Zhonghua Yi Xue Za Zhi 71 (1991) 362-365
18. MacKenzie A., Wilson H.L., Kiss-Toth E., Dower S.K., North R.A., and Surprenant A. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15 (2001) 825-835
19. Richardson A., and Parsons T. A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature 380 (1996) 538-540
20. Romer L.H., Birukov K.G., and Garcia J.G. Focal adhesions: paradigm for a signaling nexus: review article. Circ Res 98 (2006) 606-616
21. Schaller M.D., Hildebrand J.D., Shannon J.D., Fox J.W., Vines R.R., and Parsons J.T. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 14 (1994) 1680-1688
22. Sidhu S.S., Mengistab A.T., Tauscher A.N., LaVail J., and Basbaum C. The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene 23 (2004) 956-963
23. Tang J., Zhou H.W., Jiang J.L., Yang X.M., Li Y., Zhang H.X., et al. βig-h3 is involved in HAb18G/CD147 mediated metastasis process in human hepatoma cells. Exp Biol Med 232 (2007) 344-352
24. Tang Y., Kesavan P., Nakada M.T., and Yan L. Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res 2 (2004) 73-80
25. Taylor P.M., Woodfield R.J., Hodgkin M.N., Pettitt T.R., Martin A., Kerr D.J., et al. Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway. Oncogene 21 (2002) 5765-5772
26. Toole B.P. Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function. Curr Top Dev Biol 54 (2003) 371-389
27. Weaver V.M., Howlett A.R., Langton-Webster B., Petersen O.W., and Bissell M.J. The development of a functionally relevant cell culture model of progressive human breast cancer. Semin Cancer Biol 6 (1995) 175-184
28. Weaver V.M., Petersen O.W., Wang F., Larabell C.A., Briand P., Damsky C., et al. Reversion of the malignant phenotype of human breast cells in 3-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137 (1997) 231-245
29. Xu J., Xu H.Y., Zhang Q., Song F., Jiang J.L., Yang X.M., et al. HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res 5 (2007) 605-614
30. Yoshida S., Shibata M., Yamamoto S., Hagihara M., Asai N., Takahashi M., et al. Homooligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Eur J Biochem 267 (2000) 4372-4380
31. Zigrino P., Löffek S., and Mauch C. Tumor-stroma interactions: their role in the control of tumor cell invasion. Biochimie 87 (2005) 321-328