Significant association between neutrophil aggregation in aspirated thrombus and myocardial damage in patients with ST-segment elevation acute myocardial infarction

Circulation Journal

Volumn 73, Issue 1, 2009, Pages 139-144

  Arakawa, Kentaro ^a,f   Yasuda, Satoshi ^b   Hao, Hiroyuki ^c   Kataoka, Yu ^a   Morii, Isao ^d   Kasahara, Yoichiro ^a   Kawamura, Atsushi ^a   Ishibashi Ueda, Hatsue ^a   Miyazaki, Shunichi ^e  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

^d Hokusetsu General Hospital   (Japan)

^e KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f Fujisawa City Hospital   (Japan)

Author keywords

Inflammation; Lesion; Leukocytes; Myocardial infarction; Thrombus

Indexed keywords

CREATINE KINASE;

ACUTE HEART INFARCTION; ADULT; ARTICLE; ASPIRATION CATHETER; ATHEROSCLEROTIC PLAQUE; CELL DENSITY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY THROMBOSIS; CREATINE KINASE BLOOD LEVEL; EMERGENCY TREATMENT; FEMALE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE INJURY; HEART MUSCLE REPERFUSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROCIRCULATION; NEUTROPHIL CHEMOTAXIS; PERCUTANEOUS CORONARY INTERVENTION; REPERFUSION INJURY; ST SEGMENT ELEVATION; THROMBOCYTE AGGREGATION; THROMBUS;

AGED; BLOOD PLATELETS; CELL AGGREGATION; CORONARY VESSELS; CREATINE KINASE; ELECTROCARDIOGRAPHY; FEMALE; HEART CATHETERIZATION; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; MYOCARDITIS; NEUTROPHILS; RETROSPECTIVE STUDIES; STROKE VOLUME; THROMBOSIS; VENTRICULAR REMODELING;

EID: 58749095286     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-08-0609     Document Type: Article

References (25)

1. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105: 1135-1143.
2. Davies MJ, Thomas AC, Knapman PA, Hangartner JR. Intramyocardial platelet aggregation in patients with unstable angina suffering sudden ischemic cardiac death. Circulation 1986; 73: 418-427.
3. Merten M, Thiagarajan P. P-selectin expression on platelets determines size and stability of platelet aggregates. Circulation 2000; 102: 1931-1936.
4. Evangelista V, Manarini S, Coller BS, Smyth SS. Role of P-selectin, beta 2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion. J Thromb Haemost 2003; 1: 1048-1054.
5. Kumar A, Villani MP, Patel UK, Keith JC Jr, Schaub RG. Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model. Circulation 1999; 99: 1363-1369.
6. Arai M, Lefer DJ, So T, Dipaula A, Aversano T, Becker LC. An anti-CD18 antibody limits infarct size and preserves left ventricular function in dogs with ischemia and 48-hour reperfusion. J Am Coll Cardiol 1996; 27: 1278-1285.
7. Michelson AD, Bernald MR, Krueger LA, Valeri CR, Furman MI. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface activation. Circulation 2001; 104: 1533-1537.
8. Matetzky S, Novikov M, Gruberg L, Freimark D, Feinberg M, Elian D, et al. The significance of persistent ST elevation versus early resolution of ST segment elevation after primary PTCA. J Am Coll Cardiol 1999; 34: 1932-1938.
9. Van't Hof AWJ, Liem A, Suryapranata H, Hoorntje JCA, de Boer M, Zijilstra F. Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction. Circulation 1998; 97: 2302-2306.
10. Faraday N, Scharpf RB, Dodd-o JM, Martinez EA, Rosenfeld BA, Dorman T. Leukocytes can enhance platelet-mediated aggregation and thromboxane release via interaction of P-selectin glycoprotein ligand 1 with P-selectin. Anesthesiology 2001; 94: 145-151.
11. de Gaetano G, Cerletti C, Evangelista V. Recent advances in platelet-polymorphonuclear leukocyte interaction. Haemostasis 1999; 29: 41-49.
12. Barnard MR, Linden MD, Frelinger AL III, Li Y, Fox ML, Furman MI, et al. Effects of platelet binding on whole blood flow cytometry assays of monocyte and neutrophil procoagulant activity. J Thromb Haemost 2005; 3: 2563-2570.
13. Svilaas T, Vlaar PJ, van der Horst IC, Diercks GF, de Smet BJ, van der Heuvel AF, et al. Thrombus aspiration during primary percutaneous coronary intervention. N Engl J Med 2008; 358: 557-567.
14. Kosuge M, Kimura K, Ishikawa T, Shimizu T, Takemura T, Tsukahara K, et al. Relation between white blood cell counts and myocardial reperfusion in patients with recanalized anterior acute myocardial infarction. Circ J 2004; 68: 526-531.
15. Barron HV, Cannon CP, Murphy SA, Braunwald E, Gibson M. Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction. Circulation 2000; 102: 2329-2334.
16. Kirtane AJ, Bui A, Murphy SA, Barron HV, Gibson CM. Association of peripheral neutrophilia with adverse angiographic outcomes in ST-elevation myocardial infarction. Am J Cardiol 2004; 93: 532-536.
17. Takahashi T, Hiasa Y, Ohara Y, Miyazaki S, Ogura R, Suzuki N, et al. Relationship of admission neutrophil count to microvascular injury, left ventricular dilation, and long-term outcome in patients treated with primary angioplasty for acute myocardial infarction. Circ J 2008; 72: 867-872.
18. Kruk M, Przyłuski J, Kalińczuk Ł, Pregowski J, Deptuch T, Kadziela J, et al. Association of non-specific inflammatory activation with early mortality in patients with ST-elevation acute coronary syndrome treated with primary angioplasty. Circ J 2008; 72: 205-211.
19. Tóth-Zsámboki E, Horváth E, Vargova K, Pankotai E, Murthy K, Zsengellér Z, et al. Activation of poly (ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Mol Med 2006; 12: 221-228.
20. Mertens P, Maes A, Nuyts J, Belmans A, Desmet W, Esplugas E, et al. Recombinant P-selectin glycoprotein ligand-immunogloblin, a P-selectin antagonist, as an adjunct to thrombolysis in acute myocardial infarction: The P-selectin antagonist limitingmyonecrosis (PSALM) trial. Am Heart J 2006; 152: 125.e1-125.e8.
21. Baran KW, Nguyen M, McKendall GR, Lambrew CT, Dykstra G, Palmeri ST, et al. Double-blind, randomized trial of anti-CD18 antibody in conjunction with recombinant tissue plasminogen activator for acute myocardial infarction. Circulation 2001; 104: 2778-2783.
22. Collaborative Organization for Rheoth RX Evaluation (CORE) Investigators. Effect of Phoeth Rx on mortality, morbidity, left ventricular function, and infarct size in patients with acute myocardial infarction. Circulation 1997; 96: 192-201.
23. Faxon DP, Gibbons RJ, Chronos NA, Gurbel PA, Sheehan F; HALT-MI investigators. The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: The results of the HALT-MI study. J Am Coll Cardiol 2002; 40: 1199-1204.
24. Theroux P, Chaitman BR, Danchin N, Erhardt L, Meinertz T, Schroeder JS, et al. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations: Main results of the GUARDIAN trial. Circulation 2000; 102: 3032-3038.
25. Fukushima S, Coppen SR, Varela-Carver A, Yamahara K, Sarathchandra P, Smolenski RT, et al. A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route. Circulation 2006; 114(Suppl): I-251-I-256.