An anti-CD18 antibody limits infarct size and preserves left ventricular function in dogs with ischemia and 48-hour reperfusion

Journal of the American College of Cardiology

Volumn 27, Issue 5, 1996, Pages 1278-1285

  Arai, Masazumi ^a   Lefer, David J ^a   So, Takehiko ^a   DiPaula, Anthony ^a   Aversano, Thomas ^a   Becker, Lewis C ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY R15 7; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFICACY; FEMALE; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

EID: 0029926655     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0735-1097(95)00578-1     Document Type: Article

References (39)

1. Engler RL, Dahlgren MD, Morris DD, Peterson MA, Schmid-Schonbein GW. Role of leukocytes in response to acute myocardial ischemia reflow in dogs. Am J Physiol 1986;251:H314-3.
2. Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN. Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol 1987;253:H699-H703.
3. Horgan MJ, Lum H, Malik AB. Pulmonary edema following pulmonary artery occlusion reperfusion. Am Rev Respir Dis 1989;140:1421-8.
4. Mullane KM, Read N, Salmon JA, Moncada S. Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs. J Pharmacol Exp Ther 1984;228:510-22.
5. Litt M, Jeremy RW, Weisman HF, Winkelstein JA, Becker LC. Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Circulation 1989;80:1816-27.
6. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994;8:504-12.
7. Nathan CF. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest 1987;80:1550-60.
8. Nathan C, Srimal S, Farber C, et al. Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/ CD18 integrins. J Cell Biol 1989;109:1341-9.
9. Shappell SB, Toman C, Anderson DC, Taylor AA, Entman ML, Smith CW. Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J Immunol 1990;144:2702-11.
10. Entman ML, Youker K, Shappell SB, et al. Neutrophil adherence to isolated adult canine myocytes: evidence for a CD18-dependent mechanism. J Clin Invest 1990;85:1497-506.
11. Kishimoto TK, Larson RS, Corbi AL, Dustin ML, Staunton DE, Springer TA. The leukocyte integrins. Adv Immunol 1989;46:149-82.
12. Vedder NB, Winn RK, Rice CL, Chi EY, Arfors KE, Harlan JM. A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J Clin Invest 1988;81:939-44.
13. Horgan MJ, Wright SD, Malik AB. Antibody against leukocyte integrin CD18 prevents reperfusion-induced lung vascular injury. Am J Pbysiol (Lung Cell Mol Physiol) 1990;3:L315-9.
14. Ma X, Tsao PS, Lefer AM. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J Clin Invest 1991;88:1237-43.
15. Seewaldt-Becker E, Rothlein R, Dammgen JW. CD/18 dependent adhesion of leukocytes to endothelium and its relevance for cardiac reperfusion. In: Springer TA, Anderson DC, Rosenthal AS, Rothlein R, editors. Leukocyte Adhesion Molecules: Structure, Function, and Regulation. New York: Springer-Verlag, 1989:138-48.
16. Gomoll AW, Lekich RF, Grove RI. Efficacy of a monoclonal antibody (MoAb 60.3) in reducing myocardial injury resulting from ischemia/ reperfusion in the ferret. J Cardiovasc Pharmacol 1991;17:873-78.
17. Perez RG, Arai M, Richardson C, et al. Factors modifying the protective effect of anti-CD18 antibodies on myocardial reperfusion injury in the anesthetized dog. Am J Physiol. In press.
18. Tanaka M, Brooks SE, Richard VJ, et al. Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 1993;87:526-35.
19. Heymann MA, Payne BD, Hoffman JIE, Rudolph AM. Blood flow measurements with radionuclide labeled particles. Prog Cardiovasc Dis 1977;20:50-79.
20. Becker LC, Schuster EH, Jugdutt BI, Hutchins GM, Bulkley BH. Relationship between myocardial infarct size and occluded bed size in the dog: difference between left anterior descending and circumflex coronary artery occlusions. Circulation 1983;67:549-57.
21. Ambrosio G, Weisman HF, Mannisi JA, Becker LC. Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow. Circulation 1989;80:1846-61.
22. Sandler H, Dodge HT. The use of single plane angiocardiograms for the calculation of left ventricular volume in man. Am Heart J 1968;75:325-34.
23. Sheehan FH, Bolson EL, Dodge HT, Mathey DG, Schofer J, Woo W-H. Advantages and applications of the centerline method for characterizing regional ventricular function. Circulation 1986;74:293-305.
24. Mullane KM, Kraemer R, Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 1985;15:157-67.
25. Yamazaki T, Seko Y, Tamatani T, et al. Expression of intercellular adhesion molecule-1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules. Am J Pathol 1993;143:410-8.
26. Simpson PJ, Todd RF III, Mickelson JK, et al. Sustained limitation of myocardial reperfusion injury by a monoclonal antibody that alters leukocyte function. Circulation 1990;81:226-37.
27. Forman MB, Pitarys CJ II, Vildibill HD, et al. Pharmacologic perturbation of neutrophils by fluosol results in a sustained reduction in infarct size in the canine model of reperfusion. J Am Coll Cardiol 1992;19:205-16.
28. Olafsson B, Forman MB, Puett DW, et al. Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon. Circulation 1987;76:1135-45.
29. Shuster DE, Kehrli ME Jr, Ackermann MR, Gilbert RO. Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. Proc Natl Acad Sci USA 1992;89:9225-9.
30. Argenbright WL, Letts LG, Rothlein R. Monoclonal antibodies of the leukocyte membrane CD18 glycoprotein complex and intercellular adhesion molecule-1 inhibit leukocyte-endothelial adhesion in rabbits. J Leukoc Biol 1991;49:253-7.
31. Shuster DE, Bosworth BT, Kehrli ME, Jr. Sequence of the bovine CD18-encoding cDNA: comparison with the human and murine glycoproteins. Gene 1992;114:267-71.
32. Hildreth JEK, Holt V, August JT, Pescovitz MD. Monoclonal antibodies against porcine LFA-1: species cross-reactivity and functional effects of β-subunit-species antibodies. Mol Immunol 1989;26:883-95.
33. Bulkley BH, Roberts WC. Steroid therapy during acute myocardial infarction. A cause of delayed healing and of ventricular aneurysm. Am J Med 1974;56:244-50.
34. Rosen H, Gordon S, North RJ. Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells. J Exp Med 1989;170:27-38.
35. Harlan JM, Winn RK, Vedder NB, Doerschuk CM, Rice CL. In vivo models of leukocyte adherence to endothelium. In: Harlan JM, Liu DY, editors. Adhesion: Its Role in Inflammatory Disease. New York: Freeman, 1992: 117-50.
36. Ma X-L, Lefer DJ, Lefer AM, Rothlein R. Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation 1992;86:937-46.
37. Weyrich AS, Ma X-L, Lefer DJ, Albertine KH, Lefer AM. In vivo neutralization of P-selection protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest 1993;91:2620-9.
38. Weisman HF, Bartow T, Leppo MK, et al. Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 1990;249:146-51.
39. Ma X-L, Weyrich AS, Krantz S, Lefer AM. Mechanisms of the cardioprotective actions of WEB-2170, a platelet activating factor antagonist, in myocardial ischemia and reperfusion. J Pharmacol Exp Ther 1992;260:1229-36.