Dorsal cochlear nucleus hyperactivity and tinnitus: Are they related?

American Journal of Audiology

Volumn 17, Issue 2, 2008, Pages

  Kaltenbach, James A ^a   Godfrey, Donald A ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TOLEDO   (United States)

Author keywords

Dorsal cochlear nucleus; Hyperactivity; Noise exposure; Plasticity; Tinnitus

Indexed keywords

ANIMAL; AUDITORY NERVOUS SYSTEM; AUDITORY THRESHOLD; COCHLEAR NUCLEUS; ELECTROSTIMULATION; HAIR CELL; HUMAN; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NOISE; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOPHYSICS; REVIEW; SOUND DETECTION; TINNITUS;

ANIMALS; AUDITORY FATIGUE; AUDITORY PATHWAYS; COCHLEAR NUCLEUS; ELECTRIC STIMULATION; HAIR CELLS, AUDITORY; HAIR CELLS, AUDITORY, OUTER; HUMANS; NERVE NET; NEURONAL PLASTICITY; NOISE; PSYCHOACOUSTICS; SOUND SPECTROGRAPHY; TINNITUS;

EID: 58749083949     PISSN: 10590889     EISSN: None     Source Type: Journal    
DOI: 10.1044/1059-0889(2008/08-0004)     Document Type: Review

References (94)

1. Abel, M. D., & Levine, R. A. (2004). Muscle contractions and auditory perception in tinnitus patients and nonclinical subjects. Cranio, 22, 181-191.
2. Alberti, P. W. (1987). Tinnitus in occupational hearing loss: Nosological aspects. Journal of Otolaryngology, 16, 34-35.
3. Asako, M., Holt, A. G., Griffith, R. D., Buras, E. D., & Altschuler, R. A. (2005). Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus. Journal of Neuroscience Research, 81, 102-109.
4. Atherley, G. R., Hempstock, T. I., & Noble, W. G. (1968). Study of tinnitus induced temporarily by noise. Journal of the Acoustical Society of America, 44, 1503-1506.
5. Axelsson, A., & Barrenas, M. L. (1992). Tinnitus in noise-induced hearing loss. In A. L. Dancer, D. Henderson, R. J. Salvi, & R. P. Hamernik (Eds.), Noise-induced hearing loss (pp. 269-276). Boston: Mosby-Yearbook.
6. Bäurle, J., Helmchen, C., & Grüsser-Cornehls, U. (1997). Diverse effects of Purkinje cell loss on deep cerebellar and vestibular nuclei neurons in Purkinje cell degeneration mutant mice: A possible compensatory mechanism. Journal of Comparative Neurology, 384, 580-596.
7. Behr, R., Müller, J., Shehata-Dieler, W., Schlake, H. P., Helms, J., Roosen, K., et al. (2007). The high rate CIS auditory brainstem implant for restoration of hearing in NF-2 patients. Skull Base, 17, 91-107.
8. Brozoski, T. J., & Bauer, C. A. (2005). The effect of dorsal cochlear nucleus ablation on tinnitus in rats. Hearing Research, 206, 227-236.
9. Brozoski, T. J., Bauer, C. A., & Caspary, D. M. (2002). Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus. Journal of Neuroscience, 22, 2383-2390.
10. Burns, E. M. (1984). A comparison of variability among measurements of subjective tinnitus and objective stimuli. Audiology, 23, 426-440.
11. Cacace, A. T. (2003). Expanding the biological basis of tinnitus: Crossmodal origins and the role of neuroplasticity. Hearing Research, 175, 112-132.
12. Cacace, A. T., Lovely, T. J., McFarland, D. J., Parnes, S. M., & Winter, D. F. (1994). Anomalous cross-modal plasticity following posterior fossa surgery: Some speculations on gaze-evoked tinnitus. Hearing Research, 81, 22-32.
13. Cacace, A. T., Lovely, T. J., Winter, D. F., Parnes, S. M., & McFarland, D. J. (1994). Auditory perceptual and visual-spatial characteristics of gaze-evoked tinnitus. Audiology, 33, 291-303.
14. Chang, H., Chen, K., Kaltenbach, J. A., Zhang, J., & Godfrey, D. A. (2002). Effects of acoustic trauma on dorsal cochlear nucleus neuron activity in slices. Hearing Research, 164, 59-68.
15. Chen, G.-D., & Jastreboff, P. J. (1995). Salicylate-induced abnormal activity in the inferior colliculus of rats. Hearing Research, 82, 158-178.
16. Chen, K., Waller, H. J., Godfrey, T. G., & Godfrey, D. A. (1999). Glutamergic transmission of neuronal responses to carbachol in rat dorsal cochlear nucleus slices. Neuroscience, 90, 1043-1049.
17. Chermak, G. D., & Dengerink, J. E. (1987). Characteristics of temporary noise-induced tinnitus in male and female subjects. Scandinavian Audiology, 16, 67-73.
18. Eggermont, J. J., & Roberts, L. E. (2004). The neuroscience of tinnitus. Trends in Neuroscience, 27, 676-682.
19. Finlayson, P., & Kaltenbach, J. A. (2008). Alterations in the spontaneous discharge patterns of single units in the dorsal cochlear nucleus following intense sound exposure. Manuscript submitted for publication.
20. George, R. N., & Kemp, S. (1989). Investigation of tinnitus induced by sound and its relationship to ongoing tinnitus. Journal of Speech and Hearing Research, 32, 366-372.
21. Gerken, G. M., Saunders, S. S., & Paul, R. E. (1984). Hypersensitivity to electrical stimulation of auditory nuclei follows hearing loss in cats. Hearing Research, 13, 249-259.
22. Godfrey, D. A., Godfrey, T. G., Mikesell, N. L., Waller, H. J., Yao, W., Chen, K., & Kaltenbach, J. A. (1997). Chemistry of granular and closely related regions of the cochlear nucleus. In J. Syka (Ed.), Acoustical signal processing in the central auditory system (pp. 139-153). New York: Plenum.
23. Godfrey, D. A., Park-Hellendall, J. L., Dunn, J. D., & Ross, C. D. (1987). Effects of trapezoid body and superior olive lesions on choline acetyltransferase activity in the rat cochlear nucleus. Hearing Research, 28, 253-270.
24. Heffner, H. E., & Harrington, I. A. (2002). Tinnitus in hamsters following exposure to intense sound. Hearing Research, 170, 83-95.
25. Hellman, R., Miśkiewicz, A., & Scharf, B. (1997). Loudness adaptation and excitation patterns: Effects of frequency and level. Journal of the Acoustical Society of America, 101, 2176-2185.
26. House, J. W., & Brackman, D. E. (1981). Tinnitus: Surgical treatment. In D. Evered & G. Lawrenson (Eds.), Tinnitus: Ciba Foundation Symposium 85 (pp. 204-216). London: Pitman.
27. Imig, T. J., & Durham, D. (2005). Effect of unilateral noise exposure on the tonotopic distribution of spontaneous activity in the cochlear nucleus and inferior colliculus in the cortically intact and decorticate rat. The Journal of Comparative Neurology, 490, 391-413.
28. Itoh, K., Kamiya, H., Mitani, A., Yasui, Y., Takada, M., & Mizuno, N. (1987). Direct projections from the dorsal column nuclei and the spinal trigeminal nuclei to the cochlear nuclei in the cat. Brain Research, 400, 145-150.
29. Jastreboff, P. J. (1990). Phantom auditory perception (tinnitus): Mechanisms of generation and perception. Neuroscience Research, 8, 221-254.
30. Jin, Y. M., & Godfrey, D. A. (2006). Effects of cochlear ablation on muscarinic acetylcholine receptor binding in the rat cochlear nucleus. Journal of Neuroscience Research, 83, 157-166.
31. Jin, Y. M., Godfrey, D. A., Wang, J., & Kaltenbach, J. A. (2006). Effects of intense tone exposure on choline acetyl-transferase activity in the hamster cochlear nucleus. Hearing Research, 216-217, 168-175.
32. Kaltenbach, J. A. (2006). Summary of evidence pointing to a role of the dorsal cochlear nucleus in the etiology of tinnitus. Acta Otolaryngologica Supplementum, 556, 20-26.
33. Kaltenbach, J. A. (2007). The dorsal cochlear nucleus as a contributor to tinnitus: Mechanisms underlying the induction of hyperactivity. Progress in Brain Research, 166, 89-106.
34. Kaltenbach, J. A., & Afman, C. E. (2000). Hyperactivity in the dorsal cochlear nucleus after intense sound exposure and its resemblance to tone-evoked activity: A physiological model for tinnitus. Hearing Research, 140, 165-172.
35. Kaltenbach, J. A., Godfrey, D. A., Neumann, J. B., McCaslin, D. L., Afman, C. E., & Zhang, J. (1998). Changes in spontaneous neural activity in the dorsal cochlear nucleus following exposure to intense sound: Relation to threshold shift. Hearing Research, 124, 78-84.
36. Kaltenbach, J. A., Heffner, H. E., Zhang, J., Mathog, T. A., & Zacharek, M. A. (2001). Neuro-physiological mechanisms of noise-induced tinnitus. In D. Henderson, D. Prasher, R. Kopke, R. Salvi, & R. Hamernik (Eds.), Noise induced hearing loss, basic mechanisms, prevention and control (pp. 153-168). London: Noise Research Network.
37. Kaltenbach, J. A., & Lazor, J. (1991). Tonotopic maps obtained from the surface of the dorsal cochlear nucleus of the hamster and rat. Hearing Research, 51, 149-160.
38. Kaltenbach, J. A., & McCaslin, D. (1996). Increases in spontaneous activity in the dorsal cochlear nucleus following exposure to high intensity sound: A possible neural correlate of tinnitus. Auditory Neuroscience, 3, 57-78.
39. Kaltenbach, J. A., Rachel, J. D., Mathog, T. A., Zhang, J. S., Falzarano, P. R., & Lewandowski, M. (2002). Cisplatin-induced hyperactivity in the dorsal cochlear nucleus and its relation to outer hair cell loss: Relevance to tinnitus. Journal of Neurophysiology, 88, 699-714.
40. Kaltenbach, J. A., Zacharek, M. A., Zhang, J. S., & Frederick, S. (2004). Activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense tone exposure. Neuroscience Letters, 355, 121-125.
41. Kaltenbach, J. A., Zhang, J. S., & Afman, C. E. (2000). Plasticity of spontaneous neural activity in the dorsal cochlear nucleus after intense sound exposure. Hearing Research, 147, 282-292.
42. Kaltenbach, J. A., Zhang, J., & Finlayson, P. (2005). Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus. Hearing Research, 206, 200-226.
43. Kanold, P. O., & Young, E. D. (2001). Proprioceptive information from the pinna provides somatosensory input to cat dorsal cochlear nucleus. Journal of Neuroscience, 21, 7848-7858.
44. Levine, R. A. (1999). Somatic (craniocervical) tinnitus and the dorsal cochlear nucleus hypothesis. American Journal of Otolaryngology, 20, 351-362.
45. Levine, R. A. (2004). Somatic tinnitus. In J. B. Snow Jr. (Ed.), Tinnitus: Theory and management (pp. 108-124). Hamilton, Ontario, Canada: Decker.
46. Levine, R. A., Abel, M., & Cheng, H. (2003). CNS somatosensory-auditory interactions elicit or modulate tinnitus. Experimental Brain Research, 153, 643-648.
47. Liberman, M. C., & Dodds, L. W. (1984). Single neuron labeling and chronic cochlear pathology. II. Stereocilia damage and alterations of spontaneous discharge rates. Hearing Research, 16, 43-53.
48. Liberman, M. C., & Kiang, N. Y.-S. (1978). Acoustic trauma in cats. Acta Otolaryngologica Supplementum, 358, 1-63.
49. Lockwood, A. H., Salvi, R. J., Coad, M. L., Towsley, M. L., Wack, D. S., & Murphy, B. W. (1998). The functional neuroanatomy of tinnitus: Evidence for limbic system links and neural plasticity. Neurology, 50, 114-120.
50. Loeb, M., & Smith, R. P. (1967). Relation of induced tinnitus to physical characteristics of the inducing stimuli. Journal of the Acoustical Society of America, 42, 453-455.
51. Lonsbury-Martin, B. L., & Martin, G. K. (2004). Otoacoustic emissions and tinnitus. In J. B. Snow Jr. (Ed.), Tinnitus: Theory and management (pp. 69-78). Hamilton, Ontario, Canada: Decker.
52. Lorente de Nó, R. (1981). The primary acoustic nuclei. New York: Raven Press.
53. Manis, P. B., Spirou, G. A., Wright, D. D., Paydar, S., & Ryugo, D. K. (1994). Physiology and morphology of complex spiking neurons in the guinea pig dorsal cochlear nucleus. Journal of Comparative Neurology, 348, 261-276.
54. McCrea, R. A., Strassman, A., & Highstein, S. M. (1987). Anatomical and physiological characteristics of vestibular neurons mediating the vertical vestibulo-ocular reflexes of the squirrel monkey. Journal of Comparative Neurology, 264, 571-594.
55. Meikle, M. B. (1987). Intra-subject variability of tinnitus: Observations from the tinnitus clinic. In H. Feldmann (Ed.), Proceedings of the Third International Tinnitus Seminar (pp. 175-180). Munster, Germany: Harsch Verlag.
56. Melamed, S. B., Kaltenbach, J. A., Church, M. W., Burgio, D. L., & Afman, C. E. (2000). Cisplatin-induced increases in spontaneous neural activity in the dorsal cochlear nucleus and associated outer hair cell loss. Audiology, 39, 24-29.
57. Melcher, J. R., Sigalovsky, I. S., Guinan, J. J., Jr., & Levine, R. A. (2000). Lateralized tinnitus studied with functional magnetic resonance imaging: Abnormal inferior colliculus activation. Journal of Neurophysiology, 83, 1058-1072.
58. Møller, A. R., Møller, M. B., & Yokota, M. (1992). Some forms of tinnitus may involve the extralemniscal auditory pathway. Laryngoscope, 102, 1165-1171.
59. Morest, D. K., Kim, J., & Bohne, B. A. (1997). Neuronal and transneuronal degeneration of auditory axons in the brainstem after cochlear lesions in the chinchilla: Cochleotopic and noncochleotopic patterns. Hearing Research, 103, 151-168.
60. Mori, K., Mitani, H., Fujita, M., & Winters, W. D. (1972). Multiple unit activity of dorsal cochlear nucleus and midbrain reticular formation during paradoxical phase of sleep. IV, A supplementary note. Electroencephalography and Clinical Neurophysiology, 33, 104-106.
61. Nelson, A. B., Krispel, C. M., Sekirnjak, C., & du Lac, S. (2003). Long-lasting increases in intrinsic excitability triggered by inhibition. Neuron, 40, 609-620.
62. Norena, A., Micheyl, C., Chery-Croze, S., & Collet, L. (2002). Psychoacoustic characterization of the tinnitus spectrum: Implications for the underlying mechanisms of tinnitus. Audiology & Neurootology, 7, 358-369.
63. Osen, K. K. (1970). Course and termination of the primary afferents in the cochlear nuclei of the cat: An experimental anatomical study. Archives Italiennes de Biologie, 108, 21-51.
64. Osen, K. K., Mugnaini, E., Dahl, A. L., & Christiansen, A. H. (1984). Histochemical localization of acetylcholinesterase in the cochlear and superior olivary nuclei: A reappraisal with emphasis on the cochlear granule cell system. Archives Italiennes de Biologie, 122, 169-212.
65. Penner, M. J. (1983). Variability in matches to subjective tinnitus. Journal of Speech and Hearing Research, 26, 263-267.
66. Penner, M. J. (1995). Tinnitus synthesis: Fluctuant and stable matches to the pitch of tinnitus. International Tinnitus Journal, 1, 79-83.
67. Penner, M. J., & Bilger, R. C. (1992). Consistent within-session measures of tinnitus. Journal of Speech and Hearing Research, 35, 694-700.
68. Petralia, R. S., Rubio, M. E., Wang, Y. X., & Wenthold, R. J. (2000). Differential distribution of glutamate receptors in the cochlear nuclei. Hearing Research, 147, 59-69.
69. Potashner, S. J., Suneja, S. K., & Benson, C. G. (2000). Altered glycinergic synaptic activities in guinea pig brain stem auditory nuclei after unilateral cochlear ablation. Hearing Research, 147, 125-136.
70. Rachel, J. D., Kaltenbach, J. A., & Janisse, J. (2002). Increases in spontaneous neural activity in the hamster dorsal cochlear nucleus following cisplatin treatment: A possible basis for cisplatin-induced tinnitus. Hearing Research, 164, 206-214.
71. Ryugo, D. K., Haenggeli, C. A., & Doucet, J. R. (2003). Multimodal inputs to the granule cell domain of the cochlear nucleus. Experimental Brain Research, 153, 477-485.
72. Salvi, R. J., & Ahroon, W. A. (1983). Tinnitus and neural activity. Journal of Speech and Hearing Research, 26, 629-632.
73. Schaette, R., & Kempter, R. (2006). Development of tinnitus-related neuronal hyperactivity through homeostatic plasticity after hearing loss: A computational model. European Journal of Neuroscience, 23, 3124-3138.
74. Schaette, R., & Kempter, R. (2008). Development of hyperactivity after hearing loss in a computational model of the dorsal cochlear nucleus depends on neuron response type. Hearing Research, 240, 57-72.
75. Shore, S. E. (2004). Sensory nuclei in tinnitus. In J. B. Snow Jr. (Ed.), Tinnitus: Theory and management (pp. 125-139). Hamilton, Ontario, Canada: Decker.
76. Shore, S. E. (2005). Multisensory integration in the dorsal cochlear nucleus: Unit responses to acoustic and trigeminal ganglion stimulation. European Journal of Neuroscience, 21, 3334-3348.
77. Shore, S. E., Koehler, S., Oldakowski, M., Hughes, L. F., & Syed, S. (2008). Dorsal cochlear nucleus responses to somatosensory stimulation are enhanced after noise-induced hearing loss. European Journal of Neuroscience, 27, 155-168.
78. Shore, S. E., Vass, Z., Wys, N. L., & Altschuler, R. A. (2000). Trigeminal ganglion innervates the auditory brainstem. Journal of Comparative Neurology, 419, 271-285.
79. Soussi, T., & Otto, S. R. (1994). Effects of electrical brainstem stimulation on tinnitus. Acta Otolaryngologica, 114, 135-140.
80. Sun, Y., Godfrey, D. A., Chen, K., Sprunger, L. K., & Rubin, A. M. (2007). Comparison of γ-aminobutyrate receptors in the medial vestibular nucleus of control and Scn8a mutant mice. Brain Research, 1186, 188-193.
81. Suneja, S. K., Potashner, S. J., & Benson, C. G. (1998). Plastic changes in glycine and GABA release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation. Experimental Neurology, 151, 273-288.
82. Tonndorf, J. (1987). The analogy between tinnitus and pain: A suggestion for a physiological basis of chronic tinnitus. Hearing Research, 28, 271-275.
83. Tyler, R. S., & Conrad-Armes, D. (1983). The determination of tinnitus loudness considering the effects of recruitment. Journal of Speech and Hearing Research, 26, 59-72.
84. Tyler, R. S., & Conrad-Armes, D. (1984). Masking of tinnitus compared to masking of pure tones. Journal of Speech and Hearing Research, 27, 106-111.
85. Tzounopoulos, T. (2008). Mechanisms of synaptic plasticity in the dorsal cochlear nucleus: Plasticity-induced changes that could underlie tinnitus. American Journal of Audiology, 17, S170-S175.
86. Wall, M., Rosenberg, M., & Richardson, D. (1987). Gaze-evoked tinnitus. Neurology, 37, 1034-1036.
87. Waller, H. J., Godfrey, D. A., & Chen, K. (1996). Effects of parallel fiber stimulation on neurons of rat dorsal cochlear nucleus. Hearing Research, 98, 169-179.
88. Weinberg, R. J., & Rustioni, A. (1987). A cuneocochlear pathway in the rat. Neuroscience, 20, 209-219.
89. Wright, D. D., & Ryugo, D. K. (1996). Mossy fiber projections from the cuneate nucleus to the cochlear nucleus in the rat. Journal of Comparative Neurology, 365, 159-172.
90. Zacharek, M. A., Kaltenbach, J. A., Mathog, T. A., & Zhang, J. S. (2002). Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: Implications on the origin of noise-induced tinnitus. Hearing Research, 172, 137-144.
91. Zhang, J., Heffner, H. E., Koay, G., & Kaltenbach, J. A. (2004). Hyperactivity in the hamster dorsal cochlear nucleus: Its relationship to tinnitus. Abstracts of the Association for Research in Otolaryngology, 144.
92. Zhang, J. S., & Kaltenbach, J. A. (1998). Increases in spontaneous activity in the dorsal cochlear nucleus of the rat following exposure to high intensity sound. Neuroscience Letters, 250, 197-200.
93. Zhang, S., & Oertel, D. (1993). Cartwheel and superficial stellate cells of the dorsal cochlear nucleus of mice: Intracellular recordings in slices. Journal of Neurophysiology, 69, 1384-1397.
94. Zhou, J., & Shore, S. E. (2004). Projections from the trigeminal nuclear complex to the cochlear nuclei: A retrograde and anterograde tracing study in the guinea pig. Journal of Neuroscience Research, 78, 901-907.