FIAT inhibition increases osteoblast activity by modulating Atf4-dependent functions

Journal of Cellular Biochemistry

Volumn 106, Issue 1, 2009, Pages 186-192

  Yu, Vionnie W C ^a,b   El Hoss, Jad ^a,b   St Arnaud, René ^a,b  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

ATF4; Bzip transcription factors; FIAT; Osteoblast; Osteocalcin gene transcription

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; COLLAGEN TYPE 1; LEUCINE ZIPPER PROTEIN; LUCIFERASE; OSTEOCALCIN; S6 KINASE; SIALOPROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FIAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; CELL ACTIVITY; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIMERIZATION; GENETIC TRANSCRIPTION; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; TRANSGENIC MOUSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; CARRIER PROTEINS; MICE; NUCLEAR PROTEINS; OSTEOBLASTS; OSTEOCALCIN; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; RNA, SMALL INTERFERING;

CITRUS MAXIMA; MUS MUSCULUS;

EID: 58649121991     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21995     Document Type: Article

References (27)

1. Akhouayri O, Quelo I, St-Arnaud R. 2005. Sequence-Specific DNA binding by the αNAC coactivator is required for potentiation of c-Jun-dependent transcription of the osteocalcin gene. Mol Cell Biol 25:3452-3460.
2. Almeida R, Allshire RC. 2005. RNA silencing and genome regulation. Trends Cell Biol 15:251-258.
3. Bayne EH, Allshire RC. 2005. RNA-directed transcriptional gene silencing in mammals. Trends Genet 21:370-373.
4. Chen H, Pan YX, Dudenhausen EE, Kilberg MS. 2004. Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient- responsive basic region/leucine zipper transcription factors as well as localized histone acetylation. J Biol Chem 279:50829-50839.
5. Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, Grosschedl R. 2006. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell 125:971-986.
6. Eferl R, Hoebertz A, Schilling AF, Rath M, Karreth F, Kenner L, Amling M, Wagner EF. 2004. The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J 23:2789-2799.
7. Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G. 2006. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab 4:441-451.
8. Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. 2003.
9. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11:619-633.
10. Hettmann T, Barton K, Leiden JM. 2000. Microphthalmia due to p53- mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol 222:110-123.
11. Jochum W, David JP, Elliott C, Wutz A, Plenk H, Jr., Matsuo K, Wagner EF. 2000. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med 6:980-984.
12. Masuoka HC, Townes TM. 2002. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 99:736-745.
13. Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H. 2004. Identification and characterization of taxilin isoforms. Biochem Biophys Res Commun 319:936-943.
14. Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R. 2000. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med 6:985-990.
15. St-Arnaud R, Elchaarani B. 2007. Identification of additional dimerization partners of FIAT, the factor inhibiting ATF4-mediated transcription. Ann NY Acad Sci 1116:208-215.
16. Tanaka T, Tsujimura T, Takeda K, Sugihara A, Maekawa A, Terada N, Yoshida N, Akira S. 1998. Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells 3:801-810.
17. Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, Mandel JL, Sassone-Corsi P, Hanauer A. 1996. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature 384:567-570.
18. Wu X, Estwick SA, Chen S, Yu M, Ming W, Nebesio TD, Li Y, Yuan J, Kapur R, Ingram D, Yoder MC, Yang FC. 2006. Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells. Hum Mol Genet 15:2837-2845.
19. Xiao G, Cui Y, Ducy P, Karsenty G, Franceschi RT. 1997. Ascorbic acid- dependent activation of the osteocalcin promoter in MC3T3-E1 preosteo- blasts: Requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol 11:1103-1113.
20. Xiao G, Jiang D, Ge C, Zhao Z, Lai Y, Boules H, Phimphilai M, Yang X, Karsenty G, Franceschi RT. 2005. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem 280:30689-30696.
21. Yang X, Karsenty G. 2004. ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J Biol Chem 279:47109-47114.
22. Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka HC, Schinke T, Li L, Brancorsini S, Sassone-Corsi P, Townes TM, Hanauer A, Karsenty G. 2004. ATF4 Is a Substrate of RSK2 and an essential regulator of osteoblast biology; Implication for Coffin-Lowry Syndrome. Cell 117:387-398.
23. Yoshida K, Nogami S, Satoh S, Tanaka-Nakadate S, Hiraishi H, Terano A, Shirataki H. 2005. Interaction of the taxilin family with the nascent poly- peptide-associated complex that is involved in the transcriptional and translational processes. Genes Cells 10:465-476.
24. Yu VW, Ambartsoumian G, Verlinden L, Moir JM, Prud'homme J, Gauthier C, Roughley PJ, St-Arnaud R. 2005. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. J Cell Biol 169:591-601.
25. Yu VWC, Gauthier C, St-Arnaud R. 2006. Inhibition of ATF4 transcriptional activity by FIAT/γ-taxilin modulates bone mass accrual. Ann NY Acad Sci 1068:131-142.
26. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G. 2008a. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt- related transcription factor 2. J Biol Chem 283:5542-5553.
27. Yu VW, Gauthier C, St-Arnaud R. 2008b. FIAT represses bone matrix mineralization by interacting with ATF4 through its second leucine zipper. J Cell Biochem 105:859-865.