The initial slope of the VCO2/VO2-curve (s1) in cardiopulmonary exercise testing is a strong and independent predictor of outcome in patients with previous myocardial infarction

Clinical Research in Cardiology

Volumn 97, Issue 12, 2008, Pages 882-890

  Honold, Joerg ^a   Geiger, Lenka ^a   Assmus, Birgit ^a   Fischer Rasokat, Ulrich ^a   Schaechinger, Volker ^a   Zeiher, Andreas M ^a   Spyridopoulos, Ioakim ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Betablocker; Cardiopulmonary exercise testing; Heart failure; NT pro brain natriuretic peptide; Peak VO 2

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CARBON DIOXIDE; OXYGEN;

ADULT; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE OXYGEN CONSUMPTION; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SURVIVAL RATE; AGE; AGED; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; EXERCISE TEST; HEART FAILURE; METABOLISM; METHODOLOGY; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; RISK ASSESSMENT; STATISTICS; TREATMENT OUTCOME;

ADULT; AGE FACTORS; AGED; CARBON DIOXIDE; EXERCISE TEST; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; OXYGEN CONSUMPTION; PATIENT READMISSION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 58649120775     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-008-701-6     Document Type: Article

References (38)

1. (1999) The cardiac insufficiency bisoprolol study II (CIBIS-II): a randomised trial. Lancet 353:9-13
2. R Baba M Nagashima M Goto 1996 Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise J Am Coll Cardiol 28 1567 1572
3. O Basat S Ucak S Seber E Oztekin Y Altuntas 2006 After myocardial infarction carvedilol improves insulin resistance compared to metoprolol Clin Res Cardiol 95 99 104
4. WL Beaver K Wasserman BJ Whipp 1986 A new method for detecting anaerobic threshold by gas exchange J Appl Physiol 60 2020 2027
5. M Bohm N Werner M Kindermann 2006 Drug treatment of chronic heart failure Clin Res Cardiol 95 Suppl 4 36 54 quiz 55-56
6. RA Bruce JR Blackmon JW Jones G Strait 1963 Exercising testing in adult normal subjects and cardiac patients Pediatrics 32 suppl 742 756
7. NP Buller PA Poole-Wilson 1988 Extrapolated maximal oxygen consumption: a new method for the objective analysis of respiratory gas exchange during exercise Br Heart J 59 212 217
8. TP Chua P Ponikowski D Harrington 1997 Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure J Am Coll Cardiol 29 1585 1590
9. JN Cohn GR Johnson R Shabetai 1993 Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. the V-HeFT VA Cooperative Studies Group Circulation 87 VI5 VI16
10. 2 uptake relationship during incremental exercise in man Exp Physiol 77 51 64
11. MR Cowie A Mosterd DA Wood 1997 The epidemiology of heart failure Eur Heart J 18 208 225
12. LC Davies DP Francis M Piepoli AC Scott P Ponikowski AJ Coats 2000 Chronic heart failure in the elderly: value of cardiopulmonary exercise testing in risk stratification Heart 83 147 151
13. LC Davies R Wensel P Georgiadou 2006 Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope Eur Heart J 27 684 690
14. DP Francis W Shamim LC Davies 2000 Cardiopulmonary exercise testing for prognosis in chronic heart failure: continuous and independent prognostic value from VE/VCO(2) slope and peak VO(2) Eur Heart J 21 154 161
15. AK Gitt K Wasserman C Kilkowski 2002 Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death Circulation 106 3079 3084
16. 2 slope calculated from different time intervals in patients with suspected heart failure Int J Cardiol 118 350 355
17. FX Kleber G Vietzke KD Wernecke 2000 Impairment of ventilatory efficiency in heart failure: prognostic impact Circulation 101 2803 2809
18. HM Krumholz YT Chen Y Wang V Vaccarino MJ Radford RI Horwitz 2000 Predictors of readmission among elderly survivors of admission with heart failure Am Heart J 139 72 77
19. CJ Lavie RV Milani MR Mehra 2004 Peak exercise oxygen pulse and prognosis in chronic heart failure Am J Cardiol 93 588 593
20. DP Lipkin DA Jones JM Round PA Poole-Wilson 1988 Abnormalities of skeletal muscle in patients with chronic heart failure Int J Cardiol 18 187 195
21. DM Mancini H Eisen W Kussmaul R Mull LH Edmunds Jr JR Wilson 1991 Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure Circulation 83 778 786
22. GH Mudge S Goldstein LJ Addonizio 1993 24th Bethesda conference: cardiac transplantation. Task force 3: recipient guidelines/prioritization J Am Coll Cardiol 22 21 31
23. J Myers L Gullestad R Vagelos 2000 Cardiopulmonary exercise testing and prognosis in severe heart failure: 14 ml/kg/min revisited Am Heart J 139 78 84
24. K Norozi A Wessel R Buchhorn 2007 Is the ability index superior to the NYHA classification for assessing heart failure?: comparison of two classification scales in adolescents and adults with operated congenital heart defects Clin Res Cardiol 96 542 547
25. JO O'Neill JB Young CE Pothier MS Lauer 2005 Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers Circulation 111 2313 2318
26. M Packer MB Fowler EB Roecker 2002 Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study Circulation 106 2194 2199
27. Peters-Klimm F, Muller-Tasch T, Schellberg D, et al. (2007) Guideline adherence for pharmacotherapy of chronic systolic heart failure in general practice: a closer look on evidence-based therapy. Clin Res Cardiol 97(4):244-252
28. B Pitt G Williams W Remme 2001 The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. Eplerenone post-AMI heart failure efficacy and survival study Cardiovasc Drugs Ther 15 79 87
29. PA Poole-Wilson NP Buller DP Lipkin 1988 Regional blood flow, muscle strength and skeletal muscle histology in severe congestive heart failure Am J Cardiol 62 49E 52E
30. T Reybrouck L Mertens D Schepers J Vinckx M Gewillig 1997 Assessment of cardiorespiratory exercise function in obese children and adolescents by body mass-independent parameters Eur J Appl Physiol Occup Physiol 75 478 483
31. M Robbins G Francis FJ Pashkow 1999 Ventilatory and heart rate responses to exercise: better predictors of heart failure mortality than peak oxygen consumption Circulation 100 2411 2417
32. J Schuler B Maier S Behrens W Thimme 2006 Present treatment of acute myocardial infarction in patients over 75 years-data from the Berlin myocardial infarction registry (BHIR) Clin Res Cardiol 95 360 367
33. SF Shakar BD Lowes J Lindenfeld 2004 Peak oxygen consumption and outcome in heart failure patients chronically treated with beta-blockers J Card Fail 10 15 20
34. Simon T, Becker R, Voss F, et al (2008) Elevated B-type natriuretic peptide levels in patients with nonischemic cardiomyopathy predict occurrence of arrhythmic events. Clin Res Cardiol 97(5):306-309
35. LW Stevenson 1996 Selection and management of candidates for heart transplantation Curr Opin Cardiol 11 166 173
36. H Voller 2006 Significance of changes in habits followed by risk reduction Clin Res Cardiol 95 Suppl 6 VI6 VI11
37. Y Yasaka H Yamabe M Yokoyama 1997 Dependence of peak oxygen uptake on oxygen transport capacity in chronic heart failure: comparison of graded protocol and fixed protocol Int J Cardiol 59 149 156
38. C Zugck A Haunstetter C Kruger 2002 Impact of beta-blocker treatment on the prognostic value of currently used risk predictors in congestive heart failure J Am Coll Cardiol 39 1615 1622