Treatment of epilepsy in the elderly

Current Treatment Options in Neurology

Volumn 10, Issue 4, 2008, Pages 239-245

  Leppik, Ilo E ^a  

^a MINCEP Epilepsy Care   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; BARBITURIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CARBAMAZEPINE; DEXTROPROPOXYPHENE; DILTIAZEM; ERYTHROMYCIN; ETIRACETAM; FELBAMATE; FOSPHENYTOIN SODIUM; GABAPENTIN; HYPERICUM PERFORATUM EXTRACT; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; TOPIRAMATE; TRICYCLIC ANTIDEPRESSANT AGENT; VALPROIC ACID; VERAPAMIL; WARFARIN; ZONISAMIDE;

AGE DISTRIBUTION; AGED; AGING; AGRANULOCYTOSIS; APLASTIC ANEMIA; ATAXIA; BLURRED VISION; BONE TURNOVER; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL COMPETENCE; CLINICAL TRIAL; COGNITIVE DEFECT; DEPRESSION; DIPLOPIA; DIZZINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG CLEARANCE; DRUG CONTRAINDICATION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ELIMINATION; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG INDICATION; DRUG INHIBITION; DRUG METABOLISM; DRUG MONITORING; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ELDERLY CARE; EPILEPSY; EVIDENCE BASED MEDICINE; FOOD DRUG INTERACTION; FRACTURE; GAIT DISORDER; GASTROINTESTINAL SYMPTOM; GINGIVA HYPERPLASIA; GRAPEFRUIT JUICE; HIGH RISK POPULATION; HUMAN; HYPOCALCEMIA; HYPONATREMIA; LEUKOCYTE COUNT; LOW DRUG DOSE; MONOTHERAPY; NURSING HOME PATIENT; OSTEOLYSIS; OSTEOPOROSIS; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; POSTMARKETING SURVEILLANCE; REVIEW; RISK BENEFIT ANALYSIS; SECONDARY HYPERPARATHYROIDISM; SEDATION; SEIZURE; SIDE EFFECT; SOMNOLENCE; STEVENS JOHNSON SYNDROME; THROMBOCYTE FUNCTION; TOXIC EPIDERMAL NECROLYSIS; TREMOR; UNSPECIFIED SIDE EFFECT; VITAMIN D METABOLISM; WEIGHT GAIN;

EID: 58649117946     PISSN: 10928480     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11940-008-0026-9     Document Type: Review

References (23)

1. Cloyd JC, Lackner TE, Leppik IE: Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics. Arch Fam Med 1994, 3:589-598.
2. Lackner TE, Cloyd JC, Thomas LW, et al.: Antiepileptic drug use in nursing home residents: Effect of age, gender, and comedication on patterns of use. Epilepsia 1998, 39:1083-1087.
3. Garrard J, Harms S, Hardie N, et al.: Antiepileptic drug use in nursing home admissions. Ann Neurol 2003, 54:75-85.
4. Birnbaum A, Hardie NA, Leppik IE, et al.: Variability of total phenytoin serum concentrations within elderly nursing home residents. Neurology 2003, 60:555-559.
5. Rowan AJ, Ramsay RE, ColAins JF, et al.: New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005, 64:1868-1873.
6. Morrell MJ, Leppik I, French J, et al.: The KEEPER trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based study. Epilepsy Res 2003, 54:153-161.
7. Morrell MJ, McLean MJ, Willmore LJ, et al.: Efficacy of gabapentin as adjunctive therapy in a large, multicenter study. The Steps Study Group. Seizure 2000, 9:241-248.
8. Hauser WA: SeTzure disorders: the changes with age. Epilepsia 1992, 33(Suppl 4):S6-S14.
9. Hauser WA, Annegers JF, Kurland LT: Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993, 34:453-468.
10. Cloyd JC, Remmel RP: Antiepileptic drug pharmacokinetics and interactions: Impact on the treatment of epilepsy. Pharmacotherapy 2000, 20(8 Pt 2):139S-151S.
11. Firth M, Prather CM: Gastrointestinal motility problems in the elderly patient. Gastroenterology 2002, 122:1688-1700.
12. Brodie MJ, Overstall PW, Giorgi L: Multicentre, doubleblind randomized comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Res 1999, 37:81-87.
13. Welty TE,AGidal BE, Ficker DM, et al.: Levetiracetam: a different approach to the pharmacotherapy of epilepsy. Ann Pharmacother 2002, 36:296-304.
14. McLean MJ, Gidal BE: Gabapentin dosing in the treatment of epilepsy. Clin Ther 2003, 25:1382-1406.
15. Werz MA, Lang P, Rienzo T: LevUtiracetam therapy for epilepsy: use and tolerability in the elderly [abstract 2.307]. Epilepsia 2003, 44(Suppl 9):280-281.
16. Hachad H, RagueneauRMajlessi I, Levy RH: New antiepileptic drugs: review on drug interactions. Ther Drug Monit 2002, 24:91-103.
17. Vestergaard P, Tigaran S, Rejnmark L, et al.: Fracture risk is increased in epilepsy. Acta Neurol Scand 1999, 99:269-275.
18. Leppik IE, Wolff D: Drug interactions in the elderly with epilepsy. In Seizures and Epilepsy in the Elderly. Edited by Rowan AJ, Ramsay RE. Boston: Butterworth-Heinemann; 1998: 291-302.
19. Mattson RH, Cramer J, Collins JF: A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. N Engl J Med 1992, 327:765-771.
20. Cramer J, Leppik IE, DeRue K, et al.: Tolerability of levetiracetam in elderly patients with CNS disorders. Epilepsy Res 2003, 56:135-145.
21. Sachdeo RC, Wasserstein A, Mesenbrink PJ, et al.: Effects of oxcarbazepine on sodium concentration and water handling. Ann Neurol 2002, 51:613-620.
22. Martin R, Meador K, Turrentine L, et al.: Comparative cognitive effects of carbamazepine and gabapentin in healthy senior adults. Epilepsia 2001, 42:764-771.
23. Leppik IE: Introduction to the International Geriatric Epilepsy Symposium (IGES). Epilepsy Res 2006, 68(Suppl 1):1-4.