Predictive Factors for Early HBeAg Seroconversion in Acute Exacerbation of Patients With HBeAg-Positive Chronic Hepatitis B

Gastroenterology

Volumn 136, Issue 2, 2009, Pages 505-512

  Kim, Hyoung Su ^a   Kim, Ha Jung ^a   Shin, Woon Geon ^a   Kim, Kyung Ho ^a   Lee, Jin Heon ^a   Kim, Hak Yang ^a   Jang, Myoung Kuk ^a  

^a Hallym University Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA2A INTERFERON; ANTIVIRUS AGENT; CLEVUDINE; ENTECAVIR; HEPATITIS B ANTIBODY; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; INTERFERON ALFA PLUS LAMIVUDINE; LAMIVUDINE; LAMIVUDINE PLUS PEGYLATED INTERFERON ALFA; UNCLASSIFIED DRUG; VIRUS DNA;

ADULT; AGE; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CHRONIC DISEASE; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE EXACERBATION; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; DNA EXTRACTION; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NORMAL VALUE; POLYMERASE CHAIN REACTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; RISK FACTOR; SEROCONVERSION; SERODIAGNOSIS; TREATMENT PLANNING; VERTICAL TRANSMISSION; VIRUS LOAD;

EID: 58649089150     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.10.089     Document Type: Article

References (30)

1. Lee W.M. Hepatitis B virus infection. N Engl J Med 337 (1997) 1733-1745
2. Yuen M.F., and Lai C.L. Natural history of chronic hepatitis B virus infection. J Gastroenterol Hepatol 15 Suppl (2000) E20-E24
3. Liaw Y.F., Chu C.M., Huang M.J., et al. Determinants for hepatitis B e antigen clearance in chronic type B hepatitis. Liver 4 (1984) 301-306
4. Liaw Y.F., Yang S.S., Chen T.J., et al. Acute exacerbation in hepatitis B e antigen positive chronic type B hepatitis. A clinicopathological study. J Hepatol 1 (1985) 227-233
5. Liaw Y.F., Tai D.I., Chu C.M., et al. Acute exacerbation in chronic type B hepatitis: comparison between HBeAg and antibody-positive patients. Hepatology 7 (1987) 20-33
6. Sheen I.S., Liaw Y.F., Tai D.I., et al. Hepatic decompensation associated with hepatitis B e antigen clearance in chronic type B hepatitis. Gastroenterology 89 (1985) 732-735
7. Liaw Y.F., Chu C.M., Su I.J., et al. Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterology 84 (1983) 216-219
8. Realdi G., Alberti A., Rugge M., et al. Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. Gastroenterology 79 (1980) 195-199
9. Hoofnagle J.H., Dusheiko G.M., Seeff L.B., et al. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med 94 (1981) 744-748
10. Fattovich G., Rugge M., Brollo L., et al. Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B. Hepatology 6 (1986) 167-172
11. Lok A.S., Lai C.L., Wu P.C., et al. Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection. Gastroenterology 92 (1987) 1839-1843
12. Sánchez-Tapias J.M., Costa J., Mas A., et al. Analysis of factors predicting early seroconversion to anti-HBe in HBeAg-positive chronic hepatitis B. J Hepatol 6 (1988) 15-22
13. Yuen M.F., Yuan H.J., Hui C.K., et al. A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy. Gut 52 (2003) 416-419
14. Yuen M.F., Sablon E., Yuan H.J., et al. Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma. Hepatology 37 (2003) 562-567
15. Kao J.H., Chen P.J., Lai M.Y., et al. Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol 72 (2004) 363-369
16. Livingston S.E., Simonetti J.P., Bulkow L.R., et al. Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F. Gastroenterology 133 (2007) 1452-1457
17. Yuen M.F., Fung S.K., Tanaka Y., et al. Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C. J Clin Microbiol 42 (2004) 5036-5040
18. Jang M.K., Choi D.R., Lee J.Y., et al. Responsiveness to interferon alpha in chronic hepatitis B by presumed vertical transmission. J Infect 51 (2005) 314-317
19. Naito H., Hayashi S., and Abe K. Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J Clin Microbiol 39 (2001) 362-364
20. Song B.C., Cui X.J., and Kim H. Hepatitis B virus genotypes in Korea: an endemic area of hepatitis B virus infection. Intervirology 48 (2005) 133-137
21. Hui C.K., Leung N., Shek T.W., et al. Sustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients. Hepatology 46 (2007) 690-698
22. Tsai S.L., Chen P.J., Lai M.Y., et al. Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest 89 (1992) 87-96
23. Liaw Y.F., and Tsai S.L. Pathogenesis and clinical significance of acute exacerbations and remissions in patients with chronic hepatitis B virus infection. Viral Hepat Rev 3 (1997) 143-154
24. Chu C.M., Karayannis P., Fowler M.J.F., et al. Natural history of chronic hepatitis B virus infection m Taiwan: studies of hepatitis B virus DNA in serum. Hepatology 5 (1985) 431-434
25. Sjogren M., and Hoofnagle J.H. Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis. Gastroenterology 89 (1985) 252-258
26. Pignatelli M., Waters J., Brown D., et al. HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B virus infection and during interferon therapy in chronic hepatitis B virus infection. Hepatology 6 (1986) 349-343
27. Hsu Y.S., Chien R.N., Yeh C.T., et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology 35 (2002) 1522-1527
28. Yuan H.J., Yuen M.F., Wong D.K., et al. Determinants for the occurrence of acute exacerbation of hepatitis B virus infection in Chinese patients after HBeAg seroclearance. J Clin Microbiol 43 (2005) 1594-1599
29. Chu C.M., and Liaw Y.F. Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B. Gastroenterology 133 (2007) 1458-1465
30. Song B.C., Suh D.J., Lee H.C., et al. Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. Hepatology 32 (2000) 803-806