IrAM-An α2-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes

Developmental and Comparative Immunology

Volumn 33, Issue 4, 2009, Pages 489-498

  Buresova, Veronika ^a,b   Hajdusek, Ondrej ^a,b   Franta, Zdenek ^a,b   Sojka, Daniel ^a   Kopacek, Petr ^a  

^a INSTITUTE OF PARASITOLOGY   (Czech Republic)

^b UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

Author keywords

Chryseobacterium indologenes; Innate immunity; Ixodes ricinus; Phagocytosis; Thioester proteins; 2 Macroglobulin

Indexed keywords

ALPHA 2 MACROGLOBULIN; DOUBLE STRANDED RNA; MESSENGER RNA; METHYLAMINE; THIOESTER; 1,10 PHENANTHROLINE; 1,10-PHENANTHROLINE; METALLOPROTEINASE; PHENANTHROLINE DERIVATIVE;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BORRELIA BURGDORFERI; CHRYSEOBACTERIUM INDOLOGENES; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DISULFIDE BOND; FEMALE; GENE EXPRESSION; HEMOLYMPH; IMMUNE RESPONSE; INSECT DEVELOPMENT; INTESTINE; IXODES RICINUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; RNA INTERFERENCE; STAPHYLOCOCCUS XYLOSUS; TICK; ANIMAL; BLOOD CELL; CHEMISTRY; CHRYSEOBACTERIUM; DRUG EFFECT; GENETICS; IMMUNOLOGY; IXODES; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; SEQUENCE ALIGNMENT;

ARGASIDAE; BORRELIA BURGDORFERI; CHRYSEOBACTERIUM INDOLOGENES; IXODES RICINUS; IXODIDA; IXODIDAE; ORNITHODOROS MOUBATA; STAPHYLOCOCCUS XYLOSUS;

ALPHA-MACROGLOBULINS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHRYSEOBACTERIUM; HEMOCYTES; HEMOLYMPH; IXODES; METALLOPROTEASES; METHYLAMINES; MOLECULAR SEQUENCE DATA; PHAGOCYTOSIS; PHENANTHROLINES; RNA INTERFERENCE; SEQUENCE ALIGNMENT;

EID: 58649085263     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2008.09.011     Document Type: Article

References (47)

1. Tzou P., De Gregorio E., and Lemaitre B. How drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions. Curr Opin Microbiol 5 (2002) 102-110
2. Iwanaga S., and Lee B.L. Recent advances in the innate immunity of invertebrate animals. J Biochem Mol Biol 38 (2005) 128-150
3. Hoffmann J.A. The immune response of drosophila. Nature 426 (2003) 33-38
4. Lehane M.J., Aksoy S., and Levashina E. Immune responses and parasite transmission in blood-feeding insects. Trends Parasitol 20 (2004) 433-439
5. Osta M.A., Christophides G.K., Vlachou D., and Kafatos F.C. Innate immunity in the malaria vector Anopheles gambiae: comparative and functional genomics. J Exp Biol 207 (2004) 2551-2563
6. Taylor D. Innate immunity in ticks. J Acarol Soc Jpn 15 (2006) 109-127
7. Sonenshine D.E., and Hynes W.L. Molecular characterization and related aspects of the inate immune response in ticks. Front Biosci 13 (2008) 7043-7046
8. Kopacek P., Weise C., Saravanan T., Vitova K., and Grubhoffer L. Characterization of an alpha-macroglobulin-like glycoprotein isolated from the plasma of the soft tick Ornithodoros moubata. Eur J Biochem 267 (2000) 465-475
9. Saravanan T., Weise C., Sojka D., and Kopacek P. Molecular cloning, structure and bait region splice variants of alpha2-macroglobulin from the soft tick Ornithodoros moubata. Insect Biochem Mol Biol 33 (2003) 841-851
10. Blandin S., and Levashina E.A. Thioester-containing proteins and insect immunity. Mol Immunol 40 (2004) 903-908
11. Lagueux M., Perrodou E., Levashina E.A., Capovilla M., and Hoffmann J.A. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of drosophila. Proc Natl Acad Sci 97 (2000) 11427-11432
12. Christophides G.K., Zdobnov E., Barillas-Mury C., Birney E., Blandin S., Blass C., et al. Immunity-related genes and gene families in Anopheles gambiae. Science 298 (2002) 159-165
13. Levashina E.A., Moita L.F., Blandin S., Vriend G., Lagueux M., and Kafatos F.C. Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae. Cell 104 (2001) 709-718
14. Blandin S., Shiao S.H., Moita L.F., Janse C.J., Waters A.P., Kafatos F.C., et al. Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae. Cell 11 (2004) 661-670
15. Blandin S.A., Marois E., and Levashina E.A. Antimalarial responses in Anopheles gambiae: From a complement-like protein to a complement-like pathway. Cell Host Microb 3 (2008) 364-374
16. Nuttall P.A. Pathogen-tick-host interactions: Borrelia burgdorferi and TBE virus. Zentralbl Bakteriol 289 (1999) 492-505
17. Buresova V., Franta Z., and Kopacek P. A comparison of Chryseobacterium indologenes pathogenicity to the soft tick Ornithodoros moubata and hard tick Ixodes ricinus. J Invertebr Pathol 3 (2006) 96-104
18. Venter H., Osthoff G., and Litthauer D. Purification and characterization of a metalloprotease from Chryseobacterium indologenes Ix9 a and determination of the amino acid specificity with electrospray mass spectrometry. Protein Expr Purif 15 (1999) 282-295
19. Valenzuela J.G., Francischetti I.M., Pham V.M., Garfield M.K., Mather T.N., and Ribeiro J.M. Exploring the sialome of the tick Ixodes scapularis. J Exp Biol 205 (2002) 2843-2864
20. Iwaki D., Kawabata S., Miura Y., Kato A., Armstrong P.B., Quigley J.P., et al. Molecular cloning of Limulus alpha 2-macroglobulin. Eur J Biochem 242 (1996) 822-831
21. Rego R.O., Kovar V., Kopacek P., Weise C., Man P., Sauman I., et al. The tick plasma lectin, Dorin M, is a fibrinogen-related molecule. Insect Biochem Mol Biol 36 (2006) 291-299
22. Grunclova L., Horn M., Vancova M., Sojka D., Franta Z., Mares M., et al. Two secreted cystatins of the soft tick Ornithodoros moubata: differential expression pattern and inhibitory specificity. Biol Chem 387 (2006) 1635-1644
23. Kopacek P., Weise C., and Götz P. The prophenoloxidase from the wax moth Galleria mellonella: purification and characterization of the proenzyme. Insect Biochem Mol Biol 25 (1995) 1081-1091
24. Stepanova-Tresova G., Kopecky J., and Kuthejlova M. Identification of Borrelia bugdorferi sensu stricto. Borrelia garinii and Borrelia afzelii in Ixodes ricinus ticks from Southern Bohemia using monoclonal antibodies. Zentbl Bakteriol 289 (1999) 797-806
25. Husted L.B., Sorensen E.S., Armstrong P.B., Quigley J.P., Kristensen L., and Sottrup-Jensen L. Localization of carbohydrate attachment sites and disulfide bridges in Limulus alpha-2-macroglobulin. Evidence for two forms differing primarily in their bait region sequences. J Biol Chem 277 (2002) 43698-43706
26. Jensen P.E., and Sottrup-Jensen L. Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit. J Biol Chem 261 (1986) 15863-15869
27. Dodds A.W., and Law S.K. Structural basis of the binding specificity of the thioester-containing proteins C3, C4, and alpha 2-macroglobulin. Complement 5 (1998) 89-97
28. Dodds A.W., Ren X.D., Willis A.C., and Law S.K. The reaction mechanism of the internal thioester in the human complement component C4. Nature 379 (1996) 177-179
29. Steinbuch M., Pejaudier L., Quentin M., and Martin V. Molecular alteration of alpha-2-macroglobulin by aliphatic amines. Biochim Biophys Acta 154 (1968) 228-231
30. Pagel Van Zee J., Geraci N.S., Guerrero F.D., Wikel S.K., Stuart J.J., Nene V.M., et al. Tick genomics: the Ixodes genome project and beyond. Int J Parasitol 37 (2007) 1297-1305
31. Starkey P.M., and Barrett A.J. Evolution of alpha 2-macroglobulin. The demonstration in a variety of vertebrate species of a protein resembling human alpha 2-macroglobulin. Biochemistry 205 (1982) 91-95
32. Mutsuro J., Nakao M., Fujiki K., and Yano T. Multiple forms of alpha2-macroglobulin from a bony fish, the common carp (Cyprinus carpio): striking sequence diversity in functional sites. Immunogenetics 51 (2000) 847-855
33. Idiris A., Ohtsubo K., Yoza K., Osada T., Nakamichi N., Matsumura T., et al. Molecular cloning and structural characterization of the hagfish proteinase inhibitor of the alpha-2-macroglobulin family. J Protein Chem 22 (2003) 89-98
34. Quigley J.P., and Armstrong P.B. A homologue of alpha 2-macroglobulin purified from the hemolymph of the horseshoe crab Limulus polyphemus. J Biol Chem 260 (1985) 12715-12719
35. Lin Y.C., Vaseeharan B., Ko C.F., Chiou T.T., and Chen J.C. Molecular cloning and characterisation of a proteinase inhibitor, alpha 2-macroglobulin (alpha2-M) from the haemocytes of tiger shrimp Penaeus monodon. Mol Immunol 44 (2007) 1065-1074
36. Armstrong P.B. Proteases and protease inhibitors: a balance of activities in host-pathogen interaction. Immunobiology 21 (2006) 263-281
37. 2-macroglobulin and chicken egg white ovomacroglobulin. J Biochem 101 (1987) 199-205
38. Rasmussen M., Müller H.P., and Björck L. Protein GRAB of Streptococcus pyrogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin. J Biol Chem 274 (1999) 15336-15344
39. Fryer S.E., Bender R.C., and Bayne C.J. Inhibition of cysteine proteinase from Schistosoma mansoni larvae by alpha-macroglobulin from the plasma of Biomphalaria glabrata. J Parasitol 82 (1996) 343-347
40. Chang M.X., Nie P., Liu G.Y., Song Y., and Gao Q. Identification of immune genes in grass carp Ctenopharyngodon idella in response to infection of the parasitic copepod Sinergasilus major. Parasitol Res 96 (2005) 224-229
41. Zuo X., and Woo P.T. Natural anti-proteases in rainbow trout, Oncorhynchus mykiss and brook charr, Salvelinus fontinalis and the in vitro neutralization of fish alpha 2-macroglobulin by the metalloprotease from the pathogenic haemoflagellate, Cryptobia salmositica. Parasitology 114 (1997) 375-381
42. Onara D.F., Forlenza M., Gonzalez S.F., Rakus KŁ, Pilarczyk A., Irnazarow I., et al. Differential transcription of multiple forms of alpha-2-macroglobulin in carp (Cyprinus carpio) infected with parasites. Dev Comp Immunol 32 (2008) 339-347
43. Law S.K., and Reid K.M.B. Complement. 2nd ed. (1995), IRL Press, Oxford
44. Stroschein-Stevenson S.L., Foley E., O'Farrell P.H., and Johnson A.D. Identification of drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4 (2005) e4
45. Moita L.F., Wang-Sattler R., Michel K., Zimmermann T., Blandin S., Levashina E.A., et al. In vivo identification of novel regulators and conserved pathways of phagocytosis in A. gambiae. Immunity 23 (2005) 65-73
46. Kristensen T., Moestrup S.K., Gliemann J., Bendtsen L., Sand O., and Sottrup-Jensen L. Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor. FEBS Lett 276 (1990) 151-155
47. Pan H.J., Teng L.J., Chen Y.C., Hsueh P.R., Yang P.C., Ho S.W., et al. High protease activity of Chryseobacterium indologenes isolates associated with invasive infection. J Microbiol Immunol Infect 33 (2000) 223-226