The reaction mechanism of the internal thioester in the human complement component C4

Nature

Volumn 379, Issue 6561, 1996, Pages 177-179

  Dodds, Alister W ^a   Ren, Xiang Dong ^b   Willis, Antony C ^a   Law, S K Alex ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINO ACID; ASPARTIC ACID; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C4B; ESTER; HISTIDINE; HYDROXYL GROUP; IMIDAZOLE DERIVATIVE; THIOESTER; THIOL;

ARTICLE; COMPLEMENT FIXATION; CONFORMATIONAL TRANSITION; COVALENT BOND; HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REACTION ANALYSIS;

AMINO ACID SEQUENCE; COMPLEMENT ACTIVATION; COMPLEMENT C4; ESTERS; GLYCEROL; GLYCINE; HISTIDINE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 0030053692     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/379177a0     Document Type: Article

References (30)

1. Law, S. K. A. & Reid, K. B. M. Complement: in Focus Series 2nd edn (ed. Male, D.) (IRL, Oxford, 1995).
2. Levine, R. P. & Dodds, A. W. Curr. Topics Microbiol. Immun. 153, 73-82 (1989).
3. Ng, Y. C. & Schifferli, J. A. in Complement in Health and Disease 2nd edn (eds Whaley, K., Loos, M. & Weiler, J. M.) 199-228 (Kluwer Dordrecht, Boston, 1993).
4. Weitzman, J. B. & Law, S. K. A. in Complement in Health and Disease 2nd edn (eds Whaley, K., Loos, M. & Weiler, J. M.) 269-297 (Kluwer, Dordrecht, 1993)
5. Fearon, D. T. Current Opin. Immun. 5, 341-348 (1993).
6. Isenman, D. E., Kells, D. I. C., Cooper, N. R., Müller-Eberhard, H. J. & Pangbum, M. K. Biochemistry 20, 4458-4467 (1981).
7. Isenman, D. E. & Kells, D. I. C. Biochemistry 21, 1109-1117 (1982).
8. Tack, B. F., Harrison, R. A., Janatova, J., Thomas, M. L & Prahl, J. W. Proc. natn. Acad. Sci U.S.A. 77, 5764-5768 (1980).
9. Campbell, R. D., Gagnon, J. & Porter, R. R. Biochem. J. 199, 359-370 (1981).
10. Pangburn, M. K. & Müller-Eberhard, H. J J. exp. Med. 162, 1102-1114 (1980).
11. Law, S. K. & Levine, R. P. Proc. natn. Acad Sci. U.S.A. 74, 2701-2705 (1977)
12. Law, S. K., Lichtenberg, N A. & Levine, R. P. J. Immun. 123, 1388-1394 (1979).
13. Hostetter, M. K., Thomas, M. L., Rosen, F. S. &Tack, B F. Nature 298, 72-75 (1982).
14. Isenman, D. E. & Young, J. R J. Immun. 132, 3019-3027 (1984).
15. Law, S K. A., Dodds, A. W. & Porter, R. R. EMBO J 3, 1819-1823 (1984)
16. Dodds, A. W., Law, S. K. A. & Porter, R R. Immunogenetics 24, 279-285 (1986).
17. Belt, K. T., Carroll, M. C. & Porter, R. R Cell 36, 907-914 (1984).
18. Yu, C. Y., Belt, K. T., Giles, C. M., Campbell, R. D. & Porter, R. R. EMBO J. 5, 2873-2881 (1986).
19. Carroll, M C., Fathaltah, D. M., Bergamaschini, L, Alicot, E. M. & Isenman, D. E. Proc natn. Acad. Sci. U.S.A. 87, 6868-6872 (1990)
20. Sepp, A. et al. Protein Sci 2, 706-716 (1993).
21. Ren, X. D., Dodds, ,A. W., Enghild, J. J., Chu, C. T. & Law, S K. A. FEBS Lett. 368, 87-91 (1995).
22. Chu, C. T & Pizzo, S. V Lab. Invest 71, 792-812 (1994).
23. Enghild, J. J., Salvasen, G., Thogersen, I B. & Pizzo, S. V. J. Biol. Chem. 284, 11428-11435 (1989).
24. Schweizer, M. et al. Eur. J Biochem. 164, 375-381 (1987).
25. Braciak, T. A et al. J biol. Chem. 263, 3999-4012 (1988).
26. de Bruijn, M. H. L. & Fey, G. H. Proc. Natn. Acad. Sci. U.S.A 82, 708-712 (1985).
27. Dodds, A W. & Law, S. K. A. Complement 5, 89-97 (1988).
28. Dodds, A. W. & Law, S. K. A. Biochem J. 265, 494-502 (1990).
29. Ren, X. D., Dodds, A. W. & Law, S. K. A. Immunogenetics 37, 120-128 (1993).
30. Thomas, M. L. & Tack, B. F. Biochemistry 22, 942-947 (1983).