Treatment of pulmonary hypertension in children with chronic lung disease with newer oral therapies

Pediatric Cardiology

Volumn 29, Issue 6, 2008, Pages 1082-1086

  Krishnan, Usha ^a   Krishnan, Sankaran ^a   Gewitz, Michael ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Bosentan; Bronchopulmonary dysplasia; Pulmonary hypertension; Sildenafil

Indexed keywords

BOSENTAN; LIVER ENZYME; SILDENAFIL; STEROID;

ABSENCE OF SIDE EFFECTS; ARTICLE; BLOOD VESSEL REACTIVITY; CHILD; CHRONIC LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; ECHOCARDIOGRAPHY; HEART ATRIUM SEPTUM DEFECT; HEART CATHETERIZATION; HEART HEMODYNAMICS; HEART RIGHT LEFT SHUNT; HEART VENTRICLE SEPTUM DEFECT; HUMAN; OXYGENATION; PULMONARY HYPERTENSION; TREATMENT OUTCOME; TREATMENT RESPONSE; VIRAL RESPIRATORY TRACT INFECTION;

ADMINISTRATION, ORAL; ANTIHYPERTENSIVE AGENTS; BRONCHOPULMONARY DYSPLASIA; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; HEART CATHETERIZATION; HUMANS; HYPERTENSION, PULMONARY; INFANT; INFANT, NEWBORN; MALE; PIPERAZINES; PURINES; SULFONAMIDES; SULFONES; VASODILATOR AGENTS;

EID: 58549120752     PISSN: 01720643     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00246-008-9260-x     Document Type: Article

References (14)

1. SH Abman 2007 Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn Neonatology 91 283 290
2. HA Ghofrani R Wiedemann F Rose RT Schermuly H Olschewski N Weissmann A Gunther D Walmrath W Seeger F Grimminger 2002 Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial Lancet 360 895 900
3. A Grigg M Buchanan H Whitford 2005 Late-onset pulmonary arterial hypertension in association with graft-versus-host disease after allogeneic stem-cell transplantation Am J Hematol 80 38 42
4. TR Grover TA Parker V Balasubramaniam NE Markham SH Abman 2005 Pulmonary hypertension impairs alveolarization and reduces lung growth in the ovine fetus Am J Physiol Lung Cell Mol Physiol 288 L648 L654
5. T Humpl JT Reyes H Holtby D Stephens I Adatia 2005 Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, open-label, pilot study Circulation 111 24 3274 3280 (Epub 13 June 2005)
6. BP Madden M Allenby TK Loke A Sheth 2006 A potential role for sildenafil in the management of pulmonary hypertension in patients with parenchymal lung disease Vasc Pharmacol 44 372 376
7. PM Mourani DD Ivy AA Rosenberg TE Fagan SH Abman 2008 Left ventricular diastolic dysfunction in bronchopulmonary dysplasia J Pediatr 152 2 291 293
8. EB Rosenzweig DD Ivy A Widlitz A Doran LR Claussen D Yung SH Abman A Morganti N Nguyen RJ Barst 2005 Effects of long-term bosentan in children with pulmonary arterial hypertension J Am Coll Cardiol 46 4 697 704
9. RD Ross RO Bollinger WW Pinsky 1992 Grading the severity of congestive heart failure in infants Pediatr Cardiol 13 72 75
10. R Roy JM Couriel 2006 Secondary pulmonary hypertension Paediatr Respir Rev 7 36 44
11. LJ Rubin N Galie 2004 Pulmonary arterial hypertension. A look to the future J Am Coll Cardiol 43 S89 S90
12. KR Stenmark SH Abman 2005 Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia Annu Rev Physiol 67 623 661
13. N Weissmann B Gerigk O Kocer M Nollen S Hackemack HA Ghofrani RT Schermuly G Butrous A Schulz M Roth W Seeger F Grimminger 2007 Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide Respir Med 101 2125 2132
14. MR Wilkins GA Paul JW Strange N Tunariu W Gin-Sing WA Banya MA Westwood A Stefanidis LL Ng DJ Pennell RH Mohiaddin P Nihoyannopoulos JS Gibbs 2005 Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study Am J Respir Crit Care Med 171 1292 1297