No strong association between HER-2/neu protein overexpression and gene amplification in high-grade invasive urothelial carcinomas

Pathology and Oncology Research

Volumn 14, Issue 3, 2008, Pages 261-266

  Caner, Vildan ^a   Turk, Nilay Sen ^a   Duzcan, Fusun ^a   Tufan, N Lale Satiroglu ^a   Kelten, E Canan ^a   Zencir, Sevil ^a   Dodurga, Yavuz ^a   Bagci, Huseyin ^a   Duzcan, S Ender ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

Author keywords

FISH; HER 2 neu; Immunohistochemistry; Real time quantitative PCR urothelial carcinoma

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UROGENITAL TRACT TUMOR;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOMES, HUMAN, PAIR 17; DNA, NEOPLASM; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; RECEPTOR, ERBB-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 58549118062     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9027-y     Document Type: Article

References (25)

1. Z Latif AD Watters I Dunn 2004 HER2/neu gene amplification and protein overexpression in G3 pT2 transitional cell carcinoma of the bladder: a role for anti-HER2 therapy? Eur J Cancer 40 56 63
2. C Morrison V Zanagnolo N Ramirez 2006 HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients J Clin Oncol 24 2376 2385
3. JS Ross JA Fletcher GP Linette 2003 The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy Oncologist 8 307 325
4. P Schraml J Kononen L Bubendorf 1999 Tissue microarrays for gene amplification surveys in many different tumor types Clin Cancer Res 5 1966 1975
5. S Kruger G Weitsch H Buttner 2002 Overexpression of c-erbB-2 oncoprotein in muscle-invasive bladder carcinoma: relationship with gene amplification, clinicopathological parameters and prognostic outcome Int J Oncol 21 981 987
6. M Underwood J Barlett J Reeves 1995 c-erbB-2 gene amplification: a molecular marker in recurrent bladder tumors? Cancer Res 55 2422 2430
7. J Bartlett E Mallon T Cooke 2003 The clinical evaluation of HER-2 status: which test to use? J Pathol 199 411 417
8. C Langner C Gross P Rehak 2005 HER2 protein overexpression and gene amplification in upper urinary transitional cell carcinoma: systematic analysis applying tissue microarray technique Urology 65 176 180
9. RCJ Bast P Ravdin DF Hayes 2001 2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology J Clin Oncol 19 1865 1878
10. PJ Lamy I Nanni F Fina 2006 Reliability and discriminant validity of HER2 gene amplification and chromosome 17 aneusomy analysis by real-time PCR in primary breast cancer Int J Biol Markers 21 20 29
11. RG Edwards PN Lara AK Folkins 2002 Does HER2/neu expression provide prognostic information in patients with advanced urothelial carcinoma? Cancer 95 1009 1015
12. S Kruger G Weitsch H Buttner 2002 HER2 overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic implications Int J Cancer 102 514 518
13. Z Latif AD Watters I Dunn 2003 HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder Br J Cancer 89 1305 1309
14. RE Liminez M Hussain FJ Bianco Jr 2001 HER-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors Clin Cancer Res 7 2440 2447
15. R Simon R Atefy U Wagner 2003 HER-2 and TOP2A coamplification in urinary bladder cancer Int J Cancer 107 764 772
16. G Sauter H Moch D Moore 1993 Heterogeneity of erbB-2 gene amplification in bladder cancer Cancer Res 53 Suppl 10 2199 2203
17. LM Gjerdrum I Lielpetere LM Rasmussen 2001 Laser-assisted microdissection of membrane-mounted paraffin sections for polymerase chain reaction analysis: identification of cell populations using immunohistochemistry and in situ hybridization J Mol Diagn 3 105 110
18. D Persons R Tubbs LD Cooley 2006 HER2 fluorescence in situ hybridization Arch Pathol Lab Med 130 325 331
19. S Bose M Mohammed P Shintaku 2001 Her-2/neu gene amplification in low to moderately expressing breast cancers: possible role of chromosome 17/Her-2/neu polysomy Breast J 7 337 344
20. S Wang M Hossein Saboorian EP Frenkel 2002 Aneusomy 17 in breast cancer: its role in HER-2/neu protein expression and implication for clinical assessment of HER-2/neu status Mod Pathol 15 137 145
21. M Gallucci F Guadagni R Marzano 2005 Status of the p53, p16, RB1, and HER-2 genes and chromosomes 3, 7, 9, and 17 in advanced bladder cancer: correlation with adjacent mucosa and pathological parameters J Clin Pathol 58 367 371
22. JI Ohta Y Miyoshi H Uemura 2001 Fluorescence in situ hybridization evaluation of c-erbB-2 gene amplification and chromosomal anomalies in bladder cancer Clin Cancer Res 7 2463 2467
23. RM Hovey L Chu M Balazs 1998 Genetic alterations in primary bladder cancers and their metastases Cancer Res 58 3555 3560
24. ED Kelly BJ Yoder M Stoler 2005 The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast Am J Surg Pathol 29 1221 1227
25. H Miyamoto Y Kubota S Noguchi 2000 c-erbB-2 gene amplification as a prognostic marker in human bladder cancer Urology 55 679 683