Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease

Kardiologia Polska

Volumn 66, Issue 12, 2008, Pages 1269-1277

  Sarecka Hujar, Beata ^a   Zak, Iwona ^a   Krauze, Jolanta ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Coronary artery disease; ICAM 1; IL 6; MTHFR; Polymorphisms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTILIPEMIC AGENT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6;

ADULT; ALLELE; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; HETEROZYGOTE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; POLAND; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 58549101885     PISSN: 00229032     EISSN: 00229032     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340: 115-26.
2. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
3. Brattstrom L, Wilcken DE, Ohrvik J, et al. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998; 98: 2520-6.
4. Ridker PM, Hennekens CH, Roitman-Johnson B, et al. Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet 1998; 351: 88-92.
5. Pantoni L, Sarti C, Inzitari D. Cytokines and cell adhesion molecules in cerebral ischemia: experimental bases and therapeutic perspectives. Arterioscler Thromb Vasc Biol 1998: 18: 503-13.
6. Puthothu B, Krueger M, Bernhardt M, et al. ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels. Genes Immun 2006; 7: 322-6.
7. Castell JV, Gomez-Lechon MJ, David M, et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 1989; 242: 237-9.
8. Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369-76.
9. Araki A, Hosoi T, Orimo H, et al. Association of plasma homocysteine with serum interleukin-6 and C-peptide levels in patients with type 2 diabetes. Metabolism 2005; 54: 809-14.
10. Juo SH, Liao YC, Kuo CL, et al. The MTHFR 677 C/T polymorphism influences plasma levels of adhesion molecules and nitric oxide. Thromb Res 2008; 121: 549-54.
11. Potaczek DP, Undas A, Nowakowski T, et al. Association between inflammatory markers and the interleukin-6 -174 G/C polymorphism is abolished in peripheral arterial occlusive disease. Int Angiol 2007; 26: 318-23.
12. Pola R, Flex A, Gaetani E, et al. Synergistic effect of -174 G/C polymorphism of the interleukin-6 gene promoter and 469 E/K polymorphism of the intercellular adhesion molecule-1 gene in Italian patients with history of ischemic stroke. Stroke 2003; 34: 881-5.
13. Alpert JS, Thygesen K. Myocardial infarction redefined - a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. Eur Heart J 2000; 21: 1502-13.
14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of preparative centrifuge. Clin Chem 1972; 18: 499-502.
15. Elghannam H, Tavackoli S, Ferlic L, et al. A prospective study of genetic markers of susceptibility to infection and inflammation, and the severity, progression, and regression of coronary atherosclerosis and its response to therapy. J Mol Med 2000; 78: 562-8.
16. Nejentsev S, Laine AP, Simell O, et al. Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: no association with type 1 diabetes among Finns. Tissue Antigens 2000; 55: 568-70.
17. Zak I, Niemiec P, Sarecka B, et al. Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677→T transition in the MTHFR gene. Acta Biochim Pol 2003; 50: 527-34.
18. Goracy I, Goracy J, Suliga M, et al. C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in patients with myocardial infarction. Pol Arch Med Wewn 1999; 102: 849-54.
19. Kadziela J, Janas J, Dzielinska Z, et al. The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease. Kardiol Pol 2003; 59: 17-26.
20. Brugada R, Marian AJ. A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis 1997; 128: 107-12.
21. Motti C, Gnasso A, Bernardini S, et al. Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease. Atherosclerosis 1998; 139: 377-83.
22. Fernandez-Real JM, Broch M, Vendrell J, et al. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 2000; 85: 1334-9.
23. Rein T, Forster R, Krause A, et al. Organization of the alpha-globin promoter and possible role of nuclear factor I in an alpha-globin-inducible and a noninducible cell line. J Biol Chem 1995; 270: 19643-50.
24. Humphries SE, Luong LA, Ogg MS, et al. The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 2001; 22: 2243-52.
25. Pottratz ST, Bellido T, Mocharla H, et al. 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest 1994; 93: 944-50.
26. Chiappelli M, Tampieri C, Tumini E, et al. Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. Int J Immunogenet 2005; 32: 349-53.
27. Jiang H, Klein RM, Niederacher D, et al. C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469). A risk factor for coronary heart disease and myocardial infarction. Int J Cardiol 2002; 84: 171-7.
28. Flex A, Gaetani E, Papaleo P, et al. Proinflammatory genetic profiles in subjects with history of ischemic stroke. Stroke 2004; 35: 2270-5.
29. Kretowski A, Wawrusiewicz N, Mironczuk K, et al. Intercellular adhesion molecule 1 gene polymorphisms in Graves' disease. J Clin Endocrinol Metab 2003; 88: 4945-9.
30. Gaetani E, Flex A, Pola R, et al. The K469E polymorphism of the ICAM-1 gene is a risk factor for peripheral arterial occlusive disease. Blood Coagul Fibrinolysis 2002; 13: 483-8.
31. Staunton DE, Dustin ML, Erickson HP, et al. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell 1990; 61: 243-54.
32. Bielinski SJ, Pankow JS, Li N, et al. ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: The multi-ethnic study of atherosclerosis (MESA). Atherosclerosis 2008, 201: 339-44.
33. Zak I, Balcerzyk A, Sarecka B, et al. Contemporaneous carrier-state of two or three 'proatherosclerotic' variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals. Clin Chim Acta 2005; 362: 110-8.
34. Zak I, Sarecka-Hujar B, Krauze J. Cigarette smoking, carrier state of A or G allele of 46A→G and 79C→G polymorphisms of beta2-adrenergic receptor gene, and the risk of coronary artery disease. Kardiol Pol 2008; 66: 380-6.
35. Sarecka B, Zak I, Krauze J. Synergistic effects of the polymorphisms in the PAI-1 and IL-6 genes with smoking in determining their associated risk with coronary artery disease. Clin Biochem 2008; 41: 467-73.
36. Nassar BA, Rockwood K, Kirkland SA, et al. Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic model. Clin Biochem 2006; 39: 109-14.