Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats

Journal of Zhejiang University: Science B

Volumn 10, Issue 1, 2009, Pages 14-21

  Mohd Azamai, Emey Suhana ^a   Sulaiman, Suhaniza ^a   Mohd Habib, Shafina Hanim ^a   Looi, Mee Lee ^a   Das, Srijit ^a   Abdul Hamid, Nor Aini ^a   Wan Ngah, Wan Zurinah ^a   Mohd Yusof, Yasmin Anum ^a  

^a DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Apoptosis; Bcl 2; Caspase8; Chlorella vulgaris (CV); Livercancer

Indexed keywords

BROXURIDINE; CASPASE 8; DNA NUCLEOTIDYLEXOTRANSFERASE; NATURAL PRODUCT; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CHLORELLA VULGARIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG MEGADOSE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; LIVER NODULE; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR VOLUME; WISTAR RAT;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; CHLORELLA VULGARIS; DIETARY SUPPLEMENTS; LIVER NEOPLASMS; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; TREATMENT OUTCOME;

CHLORELLA VULGARIS; RATTUS; RATTUS NORVEGICUS;

EID: 58549097127     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B0820168     Document Type: Article

References (23)

1. Akhurst, B., Croager, E.J., Farley-Roche, C.A., Ong, J.K., Dumble, M.L., Knight, B., Yeoh, G.C., 2001. A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver. Hepatology, 34 (3):519-522. [doi:10.1053/jhep.2001.26751]
2. Coultas, L., Strasser, A., 2003. The role of the Bcl-2 protein family in cancer. Semin. Cancer. Biol., 13 (2):115-123. [doi:10.1016/ S1044-579X(02)00129-3]
3. Crawford, R.A., Caldwell, C., Iles, R.K., Shepherd, J.H., Chard, T., 1998. Prognostic significance of the Bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer. Br. J. Cancer, 78 (2):210-214.
4. Davies, R.A., Knight, B., Tian, Y.W., Yeoh, G.C., Olynyk, J.K., 2006. Hepatic oval cell response to the cholinedeficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclooxygenase 2 inhibitor. Carcinogenesis, 27 (8):1607-1616. [doi:10.1093/carcin/bgi365]
5. Hanson, C.J., Bootman, M.D., Distelhorst, C.W., Maraldi, T., Roderick, H.L., 2008. The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect. Cell Calcium., 44 (3):243-258. [doi:10.1016/ j.ceca.2007.11.014]
6. Haperin, S.A., Smith, B., Nolan, C., Shay, J., Kralovec, J., 2003. Safety and immunoenhancing effect of a Chlorella derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebocontrolled trial. CMAJ, 162 (2):111-117.
7. Hasegawa, T., Noda, K., Kumamoto, S., Ando, Y., Yamada, A., Yoshikai, Y., 2000. Chlorella vulgaris culture supernatant (CVS) reduces psychological stress-induced apoptosis in thymocytes of mice. Int. J. Immunopharmacol., 22 (11):877-885. [doi:10.1016/S0192-0561(00)00049-7]
8. Hopkins-Donaldson, S., Bodmer, J.L., Bourloud, K.B., Brognara, C.B., Tschopp, J., Gross, N., 2000. Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis. Med. Pediatr. Oncol., 35 (6):608-611. [doi:10.1002/ 1096-911X(20001201)35:6<608::AID-MPO25>3.0.CO;2-U]
9. Kew, M.C., 2002. Epidemiology of hepatocellular carcinoma. Toxicology, 181-182: 35-38. [doi:10.1016/S0300-483X(02)00251-2]
10. Lampe, J.W., 2003. Spicing up a vegetarian diet: Chemopreventive effects of phytochemicals. Am. J. Clin. Nutr., 78 (Suppl. 3):579S-583S.
11. Lowes, K.N., Croager, E.J., Olynyk, J.K., Abraham, L.J., Yeoh, G.C., 2003. Oval cell-mediated liver regeneration: Role of cytokines and growth factors. J. Gastroenterol. Hepatol., 18 (1):4-12. [doi:10.1046/ j.1440-1746.2003.02906.x]
12. Md Saad, S., Mohd Yusof, Y.A., Wan Ngah, W.Z., 2006. Comparison between locally produced Chlorella vulgaris and Chlorella vulgaris from Japan on proliferation and apoptosis of liver cancer cell line, HepG2. Malaysian J. Biochem. & Molec. Biol., 13 (1):32-36.
13. Miyao, M., Shinoda, H., Takahashi, S., 2006. Caspase-3, caspase-8 and nuclear factor-kappaB expression in human cholesteatoma. Otology & Neurotology, 27 (1):8-13. [doi:10.1097/01.mao.0000180482.34545.b8]
14. National Cancer Registry of Malaysia, 2003. Cancer Incidence of Malaysia 2002. Available at http://www.crc.gov.my
15. Okuda, K., 2000. Hepatocellular carcinoma. J. Hepatol., 32 (Suppl. 1):225-237. [doi:10.1016/S0168-8278(00)80428-6]
16. Park, J.W., 2005. Hepatocellular carcinoma in Korea: Introduction and overview. Korean J. Gastroenterol., 45 (4):217-226.
17. Sano, T., Tanaka, Y., 1987. Effect of dried, powdered Chlorella vulgaris on experimental atherosclerosis and alimentary hypercholestrolemia in cholesterol-fed rabbits. Artery, 14 (2):76-84.
18. Schafer, D.F., Sorrell, M.F., 1999. Hepatocellular carcinoma. Lancet, 353 (9160):1253-1257. [doi:10.1016/S0140-6736(98)09148-X]
19. Sulaiman, S., Wan Ngah, W.Z., Shamaan, N.A., Mohd Yusof, Y.A., 2006. Chemopreventive effect of Chlorella vulgaris on liver cancer induced rats. Int. J. Cancer Res., 2 (3):234-241.
20. Surh, Y.J., 1999. Molecular mechanisms of chemopreventive effects of selected dietary and medical phenolic substances. Mutation Res., 428 (1-2):305-327.
21. Surh, Y.J., 2002. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: A short review. Food Chem. Toxicol., 40 (8):1091-1097. [doi:10.1016/ S0278-6915(02)00037-6]
22. Tee, L.B.G., Kirilak, Y., Huang, W.H., Morgan, R.H., Yeoh, G.C., 1994. Differentiation of oval cells into duct-like cells in preneoplastic liver of rats placed on a choline-deficient diet supplemented with ethionine. Carcinogenesis, 15 (12):2747-2756. [doi:10.1093/carcin/ 15.12.2747]
23. Yuspa, S.H., Poirier, M.C., 1988. Chemical carcinogenesis: From animal models to molecular models in one decade. Adv. Cancer Res., 50: 25-68. [doi:10.1016/S0065-230X(08)60434-0]