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Volumn 1, Issue 7, 2006, Pages 627-633

Opportunities to minimise risk in drug discovery and development

Author keywords

drug discovery; mechanism; risk; targets

Indexed keywords


EID: 58449131733     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.1.7.627     Document Type: Review
Times cited : (3)

References (29)
  • 1
    • 15444364957 scopus 로고    scopus 로고
    • Personal perspective on Dr Paul Janssen
    • BLACK J: Personal perspective on Dr Paul Janssen. J. Med. Chem. (2005) 48:1687-1688.
    • (2005) J. Med. Chem. , vol.48 , pp. 1687-1688
    • Black, J.1
  • 2
    • 13944283008 scopus 로고    scopus 로고
    • Interview with Sir James Black
    • NO AUTHORS LISTED
    • NO AUTHORS LISTED: Interview with Sir James Black. Mol. Interv. (2004) 4:139-142.
    • (2004) Mol. Interv. , vol.4 , pp. 139-142
  • 3
    • 0038004785 scopus 로고    scopus 로고
    • Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
    • TOBERT JA: Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. (2003) 2:517-526.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 517-526
    • Tobert, J.A.1
  • 4
    • 0025726621 scopus 로고
    • A way of looking at agonism and antagonism: Lessons from salbutamol, salmeterol and other β-adrenoreceptor agonists
    • JACK D: A way of looking at agonism and antagonism: lessons from salbutamol, salmeterol and other β-adrenoreceptor agonists. Br. J. Clin. Pharmacol. (1991) 31:501-514.
    • (1991) Br. J. Clin. Pharmacol. , vol.31 , pp. 501-514
    • Jack, D.1
  • 5
    • 33646122469 scopus 로고    scopus 로고
    • Biochemical mechanisms of new molecular entities (NMEs) approved by United States FDA during 2001-2004: Mechanisms leading to optimal efficacy and safety
    • SWINNEY DC: Biochemical mechanisms of new molecular entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety. Curr. Top. Med. Chem. (2006) 6:461-478.
    • (2006) Curr. Top. Med. Chem. , vol.6 , pp. 461-478
    • Swinney, D.C.1
  • 7
    • 4544381198 scopus 로고    scopus 로고
    • Biochemical mechanisms of drug action: What does it take for success?
    • SWINNEY DC: Biochemical mechanisms of drug action: what does it take for success? Nat. Rev. Drug Discov. (2004) 3:801-808.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 801-808
    • Swinney, D.C.1
  • 8
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
    • ARKIN MR, WELLS JA: Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. (2003) 3:301-317.
    • (2003) Nat. Rev. Drug Discov. , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 9
    • 33751172589 scopus 로고    scopus 로고
    • Functional selectivity and classical concepts of quantitiative pharmacology
    • Epub ahead of print
    • URBAN JD, CLARKE WP, VON ZASTROW M et al.: Functional selectivity and classical concepts of quantitiative pharmacology. J. Pharmacol. Exp. Ther. (2006) Epub ahead of print.
    • (2006) J. Pharmacol. Exp. Ther.
    • Urban, J.D.1    Clarke, W.P.2    Von Zastrow, M.3
  • 10
    • 7044272919 scopus 로고    scopus 로고
    • Novel mechanism of drug action: Functional selectivity at D2 dopamine receptors (a lesson for drug discovery)
    • MAILMAN RB, GUY EA: Novel mechanism of drug action: functional selectivity at D2 dopamine receptors (a lesson for drug discovery). Med. Chem. Res. (2004) 13:115-126.
    • (2004) Med. Chem. Res. , vol.13 , pp. 115-126
    • Mailman, R.B.1    Guy, E.A.2
  • 11
    • 33745511768 scopus 로고    scopus 로고
    • Slow antagonist dissociation and long-lasting in vivo receptor protection
    • VAUQUELIN G, VAN LIEFDE I: Slow antagonist dissociation and long-lasting in vivo receptor protection. Trends Pharmacol. Sci. (2006) 27:355-359.
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 355-359
    • Vauquelin, G.1    Van Liefde, I.2
  • 12
    • 0033797928 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of candesartan and losartan in man
    • FUCHS B, BREITHAUPT-GROGLER K, BELZ GG et al.: Comparative pharmacodynamics and pharmacokinetics of candesartan and losartan in man. J. Pharm. Pharmacol. (2000) 52:1075-1083.
    • (2000) J. Pharm. Pharmacol. , vol.52 , pp. 1075-1083
    • Fuchs, B.1    Breithaupt-Grogler, K.2    Belz, G.G.3
  • 13
    • 33749623857 scopus 로고    scopus 로고
    • Can binding kinetics translate to a clinically differentiated drug? from theory to practice
    • SWINNEY DC: Can binding kinetics translate to a clinically differentiated drug? From theory to practice. Let. Drug Des. Discov. (2006) 3:569-574.
    • (2006) Let. Drug Des. Discov. , vol.3 , pp. 569-574
    • Swinney, D.C.1
  • 16
    • 33646930743 scopus 로고    scopus 로고
    • Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-α
    • LONG XH, NEPHEW KP: Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-α J. Biol. Chem. (2006) 281:9607-9615.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9607-9615
    • Long, X.H.1    Nephew, K.P.2
  • 17
    • 33645095476 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotenction by NMDA receptor blockade: Memantine and beyond
    • LIPTON SA: Paradigm shift in neuroprotenction by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. (2006) 5:160-170.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 160-170
    • Lipton, S.A.1
  • 18
    • 0020536822 scopus 로고
    • Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells
    • LEE KS, TSEIN RW: Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature (1983) 302:790-794.
    • (1983) Nature , vol.302 , pp. 790-794
    • Lee, K.S.1    Tsein, R.W.2
  • 19
    • 0028174647 scopus 로고
    • 17β-(N-tert-butylcarbamoyl)-4-aza-5 α-androstane-1-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5-α-reductase
    • TIAN G, STUART JD, MOSS ML et al.:17β-(N-tert-butylcarbamoyl)-4-aza- 5 α-androstane-1-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5-α-reductase. Biochemistry (1995) 33:2291-2296.
    • (1995) Biochemistry , vol.33 , pp. 2291-2296
    • Tian, G.1    Stuart, J.D.2    Moss, M.L.3
  • 20
    • 9144251958 scopus 로고    scopus 로고
    • Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl
    • NEMETH EF, HEATON WH, MILLER M et al.: Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J. Pharmacol. Exp. Ther. (2004) 308:627-635.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 627-635
    • Nemeth, E.F.1    Heaton, W.H.2    Miller, M.3
  • 21
    • 0023711779 scopus 로고
    • Regulation of hormone secretion and cytosolic Ca2+ by extracelluar Ca2+ in parathyroid cells and C-cells: Role of voltage-sensitive Ca2+ channels
    • MUFF R, NEMETH EF, HALLER-BREM S, FISCHER JA: Regulation of hormone secretion and cytosolic Ca2+ by extracelluar Ca2+ in parathyroid cells and C-cells: role of voltage-sensitive Ca2+ channels. Arch. Biochem. Biophys. (1988) 265:128-135.
    • (1988) Arch. Biochem. Biophys. , vol.265 , pp. 128-135
    • Muff, R.1    Nemeth, E.F.2    Haller-Brem, S.3    Fischer, J.A.4
  • 22
    • 0037468902 scopus 로고    scopus 로고
    • Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. Clinical considerations and new agents
    • JORDAN VC: Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. Clinical considerations and new agents. J. Med. Chem. (2003) 46:1081-1111.
    • (2003) J. Med. Chem. , vol.46 , pp. 1081-1111
    • Jordan, V.C.1
  • 23
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • WAKELING AF, DUKES M, BOWLER J: A potent specific pure antiestrogen with clinical potential. Cancer Res. (1991) 51:3867-3873.
    • (1991) Cancer Res. , vol.51 , pp. 3867-3873
    • Wakeling, A.F.1    Dukes, M.2    Bowler, J.3
  • 24
    • 0033987120 scopus 로고    scopus 로고
    • Ascomycins: Promising agents for the treatment of inflammatory skin diseases
    • PAUL C, GRAEBER M, STUETZ A: Ascomycins: promising agents for the treatment of inflammatory skin diseases. Expert Opin. Investig. Drugs (2000) 9:69-77.
    • (2000) Expert Opin. Investig. Drugs , vol.9 , pp. 69-77
    • Paul, C.1    Graeber, M.2    Stuetz, A.3
  • 27
    • 0037313425 scopus 로고    scopus 로고
    • A proton-pump inhibitor expedition: The case histories of omeprazole and esomeprazole
    • OLBE L, CARLSSON E, LINDBERG P: A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole. Nat. Rev. Drug Discov. (2003) 2:132-225.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 132-225
    • Olbe, L.1    Carlsson, E.2    Lindberg, P.3
  • 28
    • 23844474716 scopus 로고    scopus 로고
    • The ultimate model organism: Progress in experimental medicine
    • LITTMAN BH, WILLIAMS SA: The ultimate model organism: progress in experimental medicine. Nat. Rev. Drug Discov. (2005) 4:631-647.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 631-647
    • Littman, B.H.1    Williams, S.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.