Plasma and ear tissue concentrations of enrofloxacin and its metabolite ciprofloxacin in dogs with chronic end-stage otitis externa after intravenous administration of enrofloxacin

Veterinary Dermatology

Volumn 20, Issue 1, 2009, Pages 51-59

  Cole, Lynette K ^a   Papich, Mark G ^b   Kwochka, Kenneth W ^c   Hillier, Andrew ^a   Smeak, Daniel D ^d   Lehman, Amy M ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c IVX Animal Health   (United States)

^d USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CIPROFLOXACIN; ENROFLOXACIN; QUINOLONE DERIVATIVE;

ANIMAL; ANIMAL DISEASE; ARTICLE; AUDITORY CANAL; BLOOD; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOG; DOG DISEASE; DOSE RESPONSE; EXTERNAL OTITIS; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; RANDOMIZED CONTROLLED TRIAL; SKIN; TISSUE DISTRIBUTION;

ANIMALS; ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; CIPROFLOXACIN; DOG DISEASES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EAR CANAL; FEMALE; FLUOROQUINOLONES; INJECTIONS, INTRAVENOUS; MALE; OTITIS EXTERNA; SKIN; TISSUE DISTRIBUTION;

BACTERIA (MICROORGANISMS); CANIS FAMILIARIS;

EID: 58449125199     PISSN: 09594493     EISSN: 13653164     Source Type: Journal    
DOI: 10.1111/j.1365-3164.2008.00730.x     Document Type: Article

References (34)

1. Rosser EJ. Causes of otitis externa. Veterinary Clinics of North America Small Animal Practice 2004 34 : 459 68.
2. Nesbitt GH, Schnitz JA. Chronic bacterial dermatitis and otitis: a review of 195 cases. Journal of the American Animal Hospital Association 1977 13 : 442 50.
3. Shell L. Otitis media and interna. In : Bonagura JD, ed. Kirk's Current Veterinary Therapy XII. Philadelphia, PA : WB Saunders, 1995 : 1128 32.
4. Blue JL, Wooley RE. Antibacterial sensitivity patterns of bacteria isolated from dogs with otitis externa. Journal of the American Veterinary Medical Association 1977 171 : 362 3.
5. Cole LK, Kwochka KW, Podell M et al. Evaluation of radiography, otoscopy, pneumotoscopy, impedance audiometry and endoscopy for the diagnosis of otitis media. In : Thoday KL, Foil KL, Bond R, eds. Advances in Veterinary Dermatology, Vol. 4. Oxford, UK : Blackwell Science Ltd, 2002 : 49 55.
6. Kowalski JJ. The microbial environment of the ear canal in health and disease. Veterinary Clinics of North America Small Animal Practice 1988 18 : 743 54.
7. McCarthy G, Kelly WR. Microbial species associated with the canine ear and their antibacterial sensitivity patterns. Irish Veterinary Journal 1982 36 : 53 6.
8. Marshall MJ, Harris AM, Horne JE. The bacteriological and clinical assessment of a new preparation for the treatment of otitis externa in dogs and cats. Journal of Small Animal Practice 1983 24 : 413 21.
9. Sharma VD, Rhoades HE. The occurrence and microbiology of otitis externa in the dog. Journal of Small Animal Practice 1975 16 : 241 7.
10. Kung K, Riond JL, Wanner M. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs. Journal of Veterinary Pharmacology and Therapeutics 1993 16 : 462 8.
11. Riddle C, Lemons C, Papich MG et al. Evaluation of ciprofloxacin as a representative of veterinary fluoroquinolones in susceptibility testing. Journal of Clinical Microbiology 2000 38 : 1636 7.
12. Tejedor MT, Martin JL, Navia M, Freixes J, Vila J. Mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from canine infections. Veterinary Microbiology 2003 94 : 295 301.
13. Lautzenhiser SJ, Fialkowski JP, Bjorling D, Rosin E. In vitro antibacterial activity of enrofloxacin and ciprofloxacin in combination against Escherichia coli and staphylococcal clinical isolates from dogs. Research in Veterinary Science 2001 70 : 239 41.
14. Pirro F, Scheer M, de Jong A. Additive in vitro activity of enrofloxacin and its main metabolite ciprofloxacin. Proceedings of the European Society of Veterinary Dermatology - European Congress of Veterinary Dermatology 14th Annual Congress, Pisa, 1997 : 199.
15. DeManuelle TC, Ihrke PJ, Brandt CM et al. Determination of skin concentrations of enrofloxacin in dogs with pyoderma. American Journal of Veterinary Research 1998 59 : 1599 604.
16. Bidgood T, Papich MG. Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs. Journal of Veterinary Pharmacology and Therapeutics 2005 28 : 329 41.
17. Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antimicrobial dosing of mice and men. Clinical Infectious Diseases 1998 26 : 1 12.
18. McKellar QA, Sanchez Bruni SF, Jones DG. Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine. Journal of Veterinary Pharmacology and Therapeutics 2004 27 : 503 14.
19. Wright DH, Brown GH, Peterson ML et al. Application of fluoroquinolone pharmacodynamics. Journal of Antimicrobial Chemotherapy 2000 46 : 669 83.
20. Craig WA, Vogelman B. The postantibiotic effect. Annals of Internal Medicine 1987 106 : 900 2.
21. Meinen JB, McClure JT, Rosin E. Pharmacokinetics of enrofloxacin in clinically normal dogs and mice and drug pharmacodynamics in neutropenic mice with Escherichia coli and staphylococcal infections. American Journal of Veterinary Research 1995 56 : 1219 24.
22. Wellman ML, DiBartola SP, Kohn CW. Applied physiology of body fluids in dogs and cats. In : DiBartola SP, ed. Fluid, Electrolyte, and Acid-Base Disorders. St. Louis, MO : Saunders Elsevier, 2006 : 3 26.
23. Stegemann M, Heukamp U, Scheer M et al. Kinetics of antimicrobial activity after administration of enrofloxacin in dog serum and skin: in vitro susceptibility of field isolates. Supplement to the Compendium of Continuing Education for the Practicing Veterinarian 1996 18 : 30 4.
24. Smeak DD. Total ear canal ablation and bulla osteotomy. In : Borjab MJ, ed. Current Techniques in Small Animal Surgery, 4th ed. Baltimore, MO : Williams & Wilkins, 1998 : 102 9.
25. Bermingham EC, Papich MG. Pharmacokinetics after intravenous and oral administration of enrofloxacin in sheep. American Journal of Veterinary Research 2002 63 : 1012 7.
26. Boothe DM, Boeckh A, Boothe HW et al. Tissue concentrations of enrofloxacin and ciprofloxacin in anesthetized dogs following single intravenous administration. Veterinary Therapeutics 2001 2 : 120 8.
27. Boeckh A, Boothe D, Wilkie S et al. Time course of enrofloxacin and its active metabolite in peripheral leukocytes of dogs. Veterinary Therapeutics 2001 2 : 334 44.
28. Liu P, Müller M, Derendorf H. Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations. International Journal of Antimicrobial Agents 2002 19 : 285 90.
29. Ihrke PJ, Papich MG, DeManuelle TC. The use of fluoroquinolones in veterinary dermatology. Veterinary Dermatology 1999 10 : 193 204.
30. National Committee for Clinical Laboratory Standards (NCCLS). Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals, Informational Supplement NCCLS Document M31-S1. Wayne, PA : NCCLS 2004 24 : 17.
31. Pirro F, Edingloh M, Schmeer N. Bactericidal and inhibitory activity of enrofloxacin and other fluoroquinolones in small animal pathogens. Proceedings of the Third International Veterinary Symposium on Fluoroquinolones, Supplement to Compendium on Continuing Education for the Practicing Veterinarian 1999 21 : 19 25.
32. Asuquo AE, Piddock LJV. Accumulation and killing kinetics of fifteen quinolones for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The Journal of Antimicrobial Chemotherapy 1993 31 : 865 80.
33. Zlotos G, Bucker A, Kinzig-Schippers M et al. Plasma protein binding of gyrase inhibitors. Journal of Pharmaceutical Sciences 1998 87 : 215 20.
34. Kietzmann M. Overview of the pharmacokinetic properties of fluoroquinolones in companion animals. Proceedings of the Third International Veterinary Symposium on Fluoroquinolones, Supplement to Compendium on Continuing Education for the Practicing Veterinarian 1999 21 : 7 11.