Botulinum toxin reduces anal spasm but has no effect on pain after haemorrhoidectomy

Colorectal Disease

Volumn 11, Issue 2, 2009, Pages 203-207

  Singh, B ^a   Box, B ^b   Lindsey, I ^b   George, B ^b   Mortensen, N ^b   Cunningham, Chris ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Botulinum toxin; Manometry; Open haemorrhoidectomy; Pain

Indexed keywords

BOTULINUM TOXIN A; BUPIVACAINE; CODEINE PHOSPHATE; LAXATIVE; METRONIDAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO;

ADULT; ANORECTAL PRESSURE; ANUS DISEASE; ANUS SPASM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEMORRHOID; HEMORRHOIDECTOMY; HUMAN; INCONTINENCE; MALE; PAIN ASSESSMENT; POSTOPERATIVE CARE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE;

ADULT; ANAL CANAL; BOTULINUM TOXIN TYPE A; FEMALE; HEMORRHOIDS; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; MIDDLE AGED; NEUROMUSCULAR AGENTS; PAIN, POSTOPERATIVE;

EID: 58449124738     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2008.01549.x     Document Type: Article

References (18)

1. Loder PB, Kamm MA, Nicholls RJ, Phillips RK. Haemorrhoids: Pathology, pathophysiology and aetiology. Br J Surg 1994; 81: 946-54.
2. Goligher JC, Graham NG, Clark CG, De Dombal FT, Giles G. The value of stretching the anal sphincters in the relief of post-haemorrhoidectomy pain. Br J Surg 1969; 56: 859-61.
3. Mathai V, Ong BC, Ho YH. Randomized controlled trial of lateral internal sphincterotomy with haemorrhoidectomy. Br J Surg 1996; 83: 380-2.
4. Hwang DY, Yoon SG, Kim HS, Lee JK, Kim KY. Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial. Dis Colon Rectum 2003; 46: 950-4.
5. Coskun A, Duzgun SA, Uzunkoy A, Bozer M, Aslan O, Canbeyli B. Nitroderm TTS band application for pain after hemorrhoidectomy. Dis Colon Rectum 2001; 44: 680-5.
6. Silverman R, Bendick PJ, Wasvary HJ. A randomized, prospective, double-blind, placebo-controlled trial of the effect of a calcium channel blocker ointment on pain after hemorrhoidectomy. Dis Colon Rectum 2005; 48: 1913-6.
7. Wasvary HJ, Hain J, Mosed-Vogel M, Bendick P, Barkel DC, Klein SN. Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy. Dis Colon Rectum 2001; 44: 1069-73.
8. Davies J, Duffy D, Boyt N, Aghahoseini A, Alexander D, Leveson S. Botulinum toxin (botox) reduces pain after hemorrhoidectomy: Results of a double-blind, randomized study. Dis Colon Rectum 2003; 46: 1097-102.
9. Patti R, Almasio PL, Muggeo VM et al. Improvement of wound healing after hemorrhoidectomy: A double-blind, randomized study of botulinum toxin injection. Dis Colon Rectum 2005; 48: 2173-9.
10. Brisinda G, Albanese A, Cadeddu F et al. Botulinum neurotoxin to treat chronic anal fissure: Results of a randomized 'Botox vs. Dysport' controlled trial. Aliment Pharmacol Ther 2004; 19: 695-701.
11. Patti R, Almasio PL, Arcara M et al. Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: A randomized trial. Dis Colon Rectum 2006; 49: 1741-8.
12. Brisinda G, Maria G, Bentivoglio AR, Cassetta E, Gui D, Albanese A. A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med 1999; 341: 65-9.
13. Hallet M. One man's poison - clinical application of botulinum toxin. N Engl J Med 1999; 341: 118-20.
14. Jones OM, Brading AF, Mortensen NJ. Mechanism of action of botulinum toxin on the internal anal sphincter. Br J Surg 2004; 91: 224-8.
15. Runfola M, Di Mugno M, Balletta A, Magalini SC, Gui D. Antinociceptive effect of botulinum toxin: An added value to chemical sphincterotomy in anal fissure? Dis Colon Rectum 2006; 49: 1078-9.
16. Minguez M, Melo F, Espi A et al. Therapeutic effects of different doses of botulinum toxin in chronic anal fissure. Dis Colon Rectum 1999; 42: 1016-21.
17. Carapeti EA, Kamm MA, McDonald PJ, Phillips RK. Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy. Lancet 1998; 351: 169-72.
18. Jirasiritham S, Tantivitayatan K, Jirasiritham S. Perianal blockage with 0.5% bupivacaine for postoperative pain relief in hemorrhoidectomy. J Med Assoc Thai 2004; 87: 660-4.