Urinary excretions of lipocalin-type prostaglandin D synthase predict renal injury in type-2 diabetes: A cross-sectional and prospective multicentre study

Nephrology Dialysis Transplantation

Volumn 24, Issue 2, 2009, Pages 475-482

  Uehara, Yoshio ^a   Makino, Hirofumi ^b   Seiki, Kousuke ^c   Urade, Yoshihiro ^d  

^a UNIVERSITY OF TOKYO   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c Maruha Nichiro Holdings Inc   (Japan)

^d OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

Albuminuria; Biomarker; Diabetes mellitus; Nephropathy; Prostaglandin D synthase

Indexed keywords

LIPOCALIN; PROSTAGLANDIN D SYNTHASE;

ADULT; AGED; ALBUMINURIA; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; MEMBRANE PERMEABILITY; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; URINARY EXCRETION;

ADULT; AGED; ALBUMINURIA; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REFERENCE VALUES; ROC CURVE; YOUNG ADULT;

EID: 58449120045     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn515     Document Type: Article

References (19)

1. Ruggenenti P, Remuzzi G. The role of protein traffic in the progression of renal diseases. Annu Rev Med 2000; 51: 315-327
2. Yaqoob M, McClelland P, Patrick AW et al. Tubular damage in microalbuminuric patients with primary glomerulonephritis and diabetic nephropathy. Ren Fail 1995; 17: 43-49
3. Mogensen CE, Christensen CK. Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 1984; 311: 89-93
4. Uusitupa M, Sitonen O, Penttila K. Proteinuria in newly diagnosed type 2 diabetic patients. Diabetes Care 1987; 10: 191-194
5. Alzaid AA. Microalbuminuria in patients with NIDDM: an overview. Diabetes Care 1996; 19: 79-89
6. Mimran A, Ribstein J, DuCailar G. Is microalbuminuria a marker of early intrarenal vascular dysfunction in essential hypertension? Hypertension 1994; 23(Pt 2): 1018-1021
7. Urade Y, Hayaishi O. Prostaglandin D synthase: structure and function. Vitam Horm 2000; 58: 89-120
8. Urade Y, Watanabe K, Hayaishi O. Prostaglandin D, E, and F synthases. J Lipid Mediat Cell Signal 1995; 12: 257-273
9. Ogawa M, Hirawa N, Tsuchida T et al. Urinary L-PGDS in early stage of diabetes predicts overt proteinuria following established diabetes in OLETF rats. Nephrol Dial Transplant 2006; 21: 924-934
10. Hoffmann A, Nimtz M, Conradt S. Molecular characterization of beta-trace protein in human serum and urine: a potential diagnostic marker for renal disease. Glycobiology 1997; 7: 499-506
11. Melegos DN, Grass L, Pierratos A et al. Highly elevated levels of prostaglandin D synthase in the serum of patients with renal failure. Urology 1999; 53: 32-37
12. Hirawa N, Uehara Y, Ikeda T et al. Urinary prostaglandin D synthase (β-trace) excretion increases in the early stage of diabetes mellitus. Nephron 2001; 87: 321-327
13. Hamano K, Totsuka Y, Ajima M et al. Blood sugar control reverses the increase in urinary excretion of prostaglandin D synthase in diabetic patients. Nephron 2002; 92: 77-85
14. Hirawa N, Uehara Y, Yamakado M et al. Lipocalin-type prostaglandin D synthase in essential hypertension. Hypertension 2002; 39(Pt 2): 449-454
15. Sacks DB, Bruns DE, Goldstein DE et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care 2002; 25: 750-786
16. Yagame M, Suzuki D, Jinde K et al. Significance of urinary type IV collagen in patients with diabetic nephropathy using a highly sensitive one-step sandwich enzyme immunoassay. J Clin Lab Anal 1997; 11: 110-116
17. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561-577
18. Viberti GC, Hill RD, Jarrett RJ et al. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1982; 391: 1430-1432
19. Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 1984; 310: 356-360