Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis

Archives of Neurology

Volumn 66, Issue 1, 2009, Pages 44-53

  Moll, Natalia M ^a   Cossoy, Michael B ^a,b   Fisher, Elizabeth ^a   Staugaitis, Susan M ^a   Tucky, Barbara H ^a   Rietsch, Anna M ^a   Chang, Ansi ^a   Fox, Robert J ^a   Trapp, Bruce D ^a   Ransohoff, Richard M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1;

ADULT; ARTICLE; ASTROCYTE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DISABILITY; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; UPREGULATION; WHITE MATTER;

AGED; AGED, 80 AND OVER; ASTROCYTES; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM; CHEMOKINE CXCL12; CHEMOTAXIS, LEUKOCYTE; DISEASE PROGRESSION; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTES; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MALE; MICROGLIA; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE FIBERS, MYELINATED; PREDICTIVE VALUE OF TESTS; RECEPTORS, CXCR4;

EID: 58449113120     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2008.512     Document Type: Article

References (30)

1. Charil A, Filippi M. Inflammatory demyelination and neurodegeneration in early multiple sclerosis. J Neurol Sci. 2007;259(1-2):7-15.
2. Filippi M, Rocca MA. Conventional MRI in multiple sclerosis. J Neuroimaging. 2007;17(suppl 1):3S-9S.
3. Rovaris M, Bozzali M, Santuccio G, et al. In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis. Brain. 2001;124(pt 12):2540-2549.
4. Kutzelnigg A, Lucchinetti CF, Stadelmann C, et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain. 2005;128(pt 11):2705-2712.
5. Filippi M, Rocca MA. MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system. J Neurol. 2005;252(suppl 5):v16-v24.
6. Lassmann H, Bruck W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathol. 2007;17(2):210-218.
7. Young EA, Fowler CD, Kidd GJ, et al. Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions. Ann Neurol. 2008;63(4):428-435.
8. van Waesberghe JH, Kamphorst W, De Groot CJ, et al. Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability. Ann Neurol. 1999;46(5):747-754.
9. Schmierer K, Scaravilli F, Altmann DR, Barker GJ, Miller DH. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol. 2004;56(3):407-415.
10. Truyen L, van Waesberghe JH, van Walderveen MA, et al. Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology. 1996;47(6):1469-1476.
11. Fisher E, Chang A, Fox RJ, et al. Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Ann Neurol. 2007;62(3):219-228.
12. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med. 2000;343(13):938-952.
13. Ludwin SK. The pathogenesis of multiple sclerosis: relating human pathology to experimental studies. J Neuropathol Exp Neurol. 2006;65(4):305-318.
14. Brück W. The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. J Neurol. 2005;252(suppl 5):v3-v9.
15. Flynn G, Maru S, Loughlin J, Romero IA, Male D. Regulation of chemokine receptor expression in human microglia and astrocytes. J Neuroimmunol. 2003;136(1-2):84-93.
16. Ohtani Y, Minami M, Kawaguchi N, et al. Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells. Neurosci Lett. 1998;249(2-3):163-166.
17. Li M, Ransohoff RM. Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Prog Neurobiol. 2008;84(2):116-131.
18. Pashenkov M, Soderstrom M, Link H. Secondary lymphoid organ chemokines are elevated in the cerebrospinal fluid during central nervous system inflammation. J Neuroimmunol. 2003;135(1-2):154-160.
19. Krumbholz M, Theil D, Cepok S, et al. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain. 2006;129(pt 1):200-211.
20. Calderon TM, Eugenin EA, Lopez L, et al. A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. J Neuroimmunol. 2006;177(1-2):27-39.
21. McCandless EE, Piccio L, Woerner BM, et al. Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis [published online ahead of print February 14, 2008]. Am J Pathol. 2008;172(3):799-808.
22. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L. Axonal transection in the lesions of multiple sclerosis. N Engl J Med. 1998;338(5):278-285.
23. Moll NM, Rietsch AM, Ransohoff AJ, et al. Cortical demyelination in PML and MS: similarities and differences. Neurology. 2008;70(5):336-343.
24. Woerner BM, Warrington NM, Kung AL, Perry A, Rubin JB. Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. Cancer Res. 2005;65(24):11392-11399.
25. Boyko OB, Alston SR, Fuller GN, Hulette CM, Johnson GA, Burger PC. Utility of postmortem magnetic resonance imaging in clinical neuropathology. Arch Pathol Lab Med. 1994;118(3):219-225.
26. Nessler S, Boretius S, Stadelmann C, et al. Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage. Brain. 2007;130(pt 8):2186-2198.
27. Chen S, Tuttle DL, Oshier JT, et al. Transforming growth factor-beta1 increases CXCR4 expression, stromal-derived factor-1alpha-stimulated signalling and human immunodeficiency virus-1 entry in human monocyte-derived macrophages. Immunology. 2005;114(4):565-574.
28. Jiang Y, Salafranca MN, Adhikari S, et al. Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis. J Neuroimmunol. 1998;86(1):1-12.
29. Glabinski AR, O'Bryant S, Selmaj K, Ransohoff RM. CXC chemokine receptors expression during chronic relapsing experimental autoimmune encephalomyelitis. Ann N Y Acad Sci. 2000;917:135-144.
30. Klein RS, Rubin JB. Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity. Trends Immunol. 2004;25(6):306-314.