Aspirin-resistance frequency: A prospective study in 280 healthy Turkish volunteers

Clinical and Applied Thrombosis/Hemostasis

Volumn 15, Issue 1, 2009, Pages 98-102

  Akay, O Meltem ^a   Canturk, Zerrin ^a   Akin, Enver ^a   Bal, Cengiz ^a   Gulbas, Zafer ^a  

^a OSMANGAZI UNIVERSITY MEDICAL FACULTY   (Turkey)

Author keywords

Aspirin; Platelet function; Resistance

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE VOLUME; TURKEY (REPUBLIC);

ADULT; ANTICOAGULANTS; ASPIRIN; DRUG RESISTANCE; FEMALE; HUMANS; MALE; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; PROSPECTIVE STUDIES; TURKEY;

EID: 58449109164     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029607306806     Document Type: Article

References (19)

1. Collaborative overview of randomised trials of antiplatelet therapy-I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ. 1994 ; 308: 81-106.
2. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002 ; 324: 71-86.
3. Gum PA, Kottke-Marchant K., Poggio ED, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease. Am J Cardiol. 2001 ; 88: 230-235.
4. Helgason CM, Tortorice KL, Winkler SR, et al. Aspirin response and failure in cerebral infarction. Stroke. 1993 ; 24: 345-350.
5. Pappas JM, Westengard JC, Bull BS Population variability in the effect of aspirin on platelet function. Implications for clinical trials and therapy. Arch Pathol Lab Med. 1994 ; 118: 801-804.
6. Grotemeyer KH Effects of acetylsalicylic acid in stroke patients. Evidence of nonresponders in a subpopulation of treated patients. Thromb Res. 1991 ; 63: 587-593.
7. Valles J., Santos MT, Aznar J., et al. Erythrocyte promotion of platelet reactivity decreases the effectiveness of aspirin as an antithrombotic therapeutic modality: the effect of low-dose aspirin is less than optimal in patients with vascular disease due to prothrombotic effects of erthrocytes on platelet reactivity. Circulation. 1998 ; 97: 350-355.
8. Nair GV, Davis CJ, McKenzie ME, Lowry DR, Serebruany VL Aspirin in patients with coronary artery disease:is it simply irresistible ? J Throm Thrombolysis. 2001 ; 11: 117-126.
9. Grotemeyer KH, Scharafinski HW, Husstedt IW Two-year follow-up of aspirin responder and aspirin non responder. A pilot-study including 180 post-stroke patients. Throm Res. 1993 ; 71: 397-403.
10. Mueller MR, Salat A., Stangl P., et al. Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty. Thromb Haemost. 1997 ; 78: 1003-1007.
11. Eikelboom JW, Hirsh J., Weitz JI, Johnston M., Yi Q., Yusuf S. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation. 2002 ; 105: 1650-1655.
12. Buchanan MR, Brister SJ Individual variation in the effects of ASA on platelet function:implications for the use of ASA clinically. Can J Cardiol. 1995 ; 11: 221-227.
13. Fontana P., Nolli S., Reber G., de Moerloose P. Biological effects of aspirin and clopidogrel in a randomized crossover study in 96 healthy volunteers. J Thromb Haemost. 2006 ; 4: 813-819.
14. Gonzalez-Conejero R., Rivera J., Corral J., Acuña C., Guerrero JA, Vicente V. Biological assessment of aspirin efficacy on healthy individuals. Stroke. 2005 ; 36: 276-280.
15. Hankey GJ, Eikelboom JW Aspirin resistance. Lancet. 2006 ; 367: 606-617.
16. Jousilahti P., Vartiainen E., Tuomilehto J., Puska P. Sex, age, cardiovascular risk factors and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland. Circulation. 1999 ; 99: 1165-1172.
17. Chamorro A. Role of inflammation in stroke and atherothrombosis. Cerebrovasc Dis. 2004 ; 17 (suppl 3). 1-5.
18. Erikssen G., Liestol K., Bjornholt JV, Stormorken H., Thaulow E., Erikssen J. Erythrocyte sedimentation rate: a possible marker of atherosclerosis and a strong predictor of coronary heart disease mortality. Eur Heart J. 2000 ; 21: 1614-1620.
19. Khaw KT, Wareham N., Luben R., et al. Glycated haemoglobin, diabetes, and mortality in men Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk). BMJ. 2001 ; 322: 15-18.