Prostaglandin E1 prevents liver failure after excessive hepatectomy in the rat by up-regulating Cyclin C, Cyclin D1, and Bclxl

Wound Repair and Regeneration

Volumn 17, Issue 1, 2009, Pages 62-70

  Ishibe, Atsushi ^a   Togo, Shinji ^a   Kumamoto, Takafumi ^a   Watanabe, Kazuteru ^a   Takahashi, Takuji ^a   Shimizu, Tetsuya ^a   Makino, Hirochika ^a   Matsuo, Kenichi ^a   Kubota, Toru ^a   Nagashima, Yoji ^a   Shimada, Hiroshi ^a  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYCLIN C; CYCLIN D1; CYCLIN E; CYCLINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; KI 67 ANTIGEN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROSTAGLANDIN E1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL COUNT; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME RELEASE; EXPERIMENTAL MODEL; GENE EXPRESSION; LIVER CELL DAMAGE; LIVER FAILURE; LIVER PROTECTION; LIVER REGENERATION; LIVER RESECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME; UPREGULATION;

ALANINE TRANSAMINASE; ALPROSTADIL; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; BCL-X PROTEIN; BLOTTING, WESTERN; CYCLIN C; CYCLIN D1; CYCLINS; HEPATECTOMY; HEPATOCYTES; IN SITU NICK-END LABELING; LIVER FAILURE; LIVER REGENERATION; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL RATE; UP-REGULATION;

EID: 58449103846     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2008.00442.x     Document Type: Article

References (43)

1. Kubota T, Takabe K, Yang M, Sekido H, Endo I, Ichikawa Y, Togo S, Shimada H. Minimum sizes for remnant and transplanted livers in rat. J Hep Bil Pancr Surg 1997 4 : 398 404.
2. Morita T, Togo S, Kubota T, Kamimukai N, Nishizuka I, Kobayashi T, Ichikawa Y, Ishikawa T, Takahashi S, Matsuo K, Tomaru Y, Okazaki Y, Hayashizaki Y, Shimada H. Mechanism of postoperative liver failure after excessive hepatectomy investigated using cDNA micoarray. J Hep Bil Pancr Surg 2002 9 : 352 9.
3. Yang H, Majno P, Morel P, Toso C, Triponez F, Oberholzer J, Mentha G, Lou J. Prostaglandin E1 protects human liver sinusoidal endothelial cell from apoptosis induced by hypoxia reoxygenation. Microvasc Res 2002 64 : 94 103.
4. Siendones E, Jiménez-Gómez Y, Montero JL, Gómez-Díaz C, Villalba JM, Muntané J. PGE1 abolishes the mitochondrial-independent cell death pathway induced by d-galactosamine in primary culture of rat hepatocytes. J Gastroenterol Hepatl 2005 20 : 108 16.
5. Hafez T, Moussa M, Nesim I, Baligh N, Davidson B, Abdol-Hadi A. The effect of intraportal prostaglandin E1 on adhesion molecule expression, inflammatory modulator function, and histology in canine hepatic ischemia/reperfusion injury. J Surg Res 2007 138 : 88 99.
6. Ranchal I, González R, López-Sánchez LM, Barrera P, López-Cillero P, Serrano J, Bernardos A, De la Mata M, Rodríguez-Ariza A, Muntané J. The differential effect of PGE(1) on d-galactosamine-induced nitrosative stress and cell death in primary culture of human hepatocytes. Prostaglandins Other Lipid Mediat 2007 79 : 245 59.
7. Togo S, Chen H, Takahashi T, Kubota T, Matsuo K, Morioka D, Watanabe K, Yamamoto H, Nagashima Y, Shimada H. Prostaglandin E(1) improves survival rate after 95% hepatectomy in rats. J Surg Res 2008 146 : 66 72.
8. Higgins GM, Anderson RM. Experimental pathology of liver. Arch Pathol 1931 12 : 186 202.
9. Fausto N. Liver regeneration. J Hepatol 2000 32 : 19 31.
10. Rabes HM, Wirsching R, Tuczek HV, Iseler G. Analysis of cell cycle compartments of hepatocytes after partial hepatecomy. Cell Tissue Kinet 1976 9 : 517 32.
11. Michalopoulos GK. Liver regeneration: molecular mechanisms of growth control. FASEB J 1990 4 : 176 87.
12. Hasegawa S, Kubota T, Fukuyama N, Kurosawa H, Sekido H, Togo S, Nakazawa H, Shimada H. Apoptosis of hepatocytes is a main cause of inducing lethal hepatic failure after excessive hepatectomy in rats. Transplant Proc 1999 31 : 558 9.
13. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 1995 146 : 1220 34.
14. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regress liver by transforming growth factor 1. Proc Natl Acad Sci USA 1992 89 : 5408 12.
15. Nakamura T, Arakaki R, Ichihara A. Interleukin-1 beta is a potent growth inhibitor of adult rat hepatocytes in primary culture. Exp Cell Res 1988 179 : 488 97.
16. Court FG, Wemyss-Holden SA, Dennison AR, Maddern GJ. The mystery of liver regeneration. Br J Surg 2002 89 : 1089 95.
17. Kamimukai N, Togo S, Hasegawa S, Kubota T, Kurosawa H, Li XK, Suzuki S, Shimada H. Expression of Bcl-2 family reduced apoptotic hepatocytes after excessive hepatectomy. Eur Surg Res 2001 33 : 8 15.
18. Abecassis M, Falk JA, Makowka L, Dindzans VJ, Falk RE, Levy GA. 16,16,dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection. J Clin Invest 1987 80 : 881 9.
19. 1. Transplantation 1989 48 : 447 53.
20. 1 on the terminal vascular bed. Am J Physiol 1969 217 : 563 6.
21. Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979 77 : 761 7.
22. Natori S, Fujii Y, Kurosawa H, Nakano A, Shimada H. Prostaglandin E1 protects against ischemia-reperfusion injury of the liver by inhibition of neutrophil adherence to endothelial cells. Transplantation 1997 64 : 1514 20.
23. Kuzumoto Y, Sho M, Ikeda N, Hamada K, Mizuno T, Akashi S, Tsurui Y, Kashizuka H, Nomi T, Kubo A, Kanehiro H, Nakajima Y. Significance and therapeutic potential of prostaglandin E2 receptor in hepatic ischemia/reperfusion injury in mice. Hepatology 2005 42 : 608 17.
24. Masaki N, Ohta Y, Shirataki H, Ogata I, Hayashi S, Yamada S, Hirata K, Nagoshi S, Mochida S, Tomiya T. Hepatocyte membrane stabilization by prostaglandins E1 and E2: favorable effects on rat liver injury. Gastroenterology 1992 102 : 572 6.
25. Wang J, Li W, Min J, Ou Q, Chen J, Song E. Intrasplenic transplantation of allogeneic hepatocytes modified by BCL-2 gene protects rats from acute liver failure. Transplant Proc 2004 36 : 2924 6.
26. Takushi Y, Shiraishi M, Nozato E, Toyoda A, Nishimaki T. Expression of anti-apoptotic protein, Bcl-2, in liver regeneration after a partial hepatectomy. J Surg Res 2006 134 : 93 101.
27. de la Coste A, Fabre M, McDonell N, Porteu A, Gilgenkrantz H, Perret C, Kahn A, Mignon A. Differential protective effects of Bcl-xL and Bcl-2 on apoptotic liver injury in transgenic mice. Am J Physiol 1999 277 : 702 8.
28. Akcali KC, Dalgic A, Ucar A, Haj KB, Guvenc D. Expression of bcl-2 gene family during resection induced liver regeneration: comparison between hepatectomized and sham groups. World J Gastroenterol 2004 10 : 279 83.
29. Kataoka K, Takikawa Y, Lin SD, Suzuki K. Prostaglandin E2 receptor EP4 agonist induces Bcl-xL and independently activates proliferation signals in mouse primary hepatocytes. J Gastroenterol 2005 40 : 610 6.
30. Casado M, Callejas NA, Rodrigo J, Zhao X, Dey SK, Boscá L, Martín-Sanz P. Contribution of cyclooxygenase 2 to liver regeneration after partial hepatectomy. FASEB J 2001 15 : 2016 8.
31. Andreis PG, Whitfield JF, Armato U. Stimulation of DNA synthesis and mitosis of hepatocytes in primary cultures of neonatal rat liver by arachidonic acid and prostaglandins. Exp Cell Res 1981 134 : 265 72.
32. Little P, Skouteris GG, Ord MG, Stocken LA. Serum from partially hepatectomized rats induces primary hepatocytes to enter S phase: a role for prostaglandins? J Cell Sci 1988 91 : 549 53.
33. Kimura M, Osumi S, Ogihara M. Prostaglandin E2 (EP1) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-α. Endocrinology 2001 142 : 4428 40.
34. Roselli HT, Su M, Washington K, Kerins DM, Vaughan DE, Russell WE. Liver regeneration is transiently impaired in urokinase-deficient mice. Am J Physiol 1998 275 : 1472 9.
35. Albrecht JH, Poon RY, Ahonen CL, Rieland BM, Deng C, Crary GS. Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver. Oncogene 1998 16 : 2141 50.
36. Nagahara H, Ezhevsky SA, Vocero-Akbani AM, Kaldis P, Solomon MJ, Dowdy SF. Transforming growth factor beta targeted inactivation of cyclin E: cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc Natl Acad Sci USA 1999 96 : 14961 6.
37. Ehrenfried JA, Ko TC, Thompson EA, Evers BM. Cell cycle-mediated regulation of hepatic regeneration. Surgery 1997 122 : 927 35.
38. Léopold P, O'Farrell PH. An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell 1991 66 : 1207 16.
39. Lew DJ, Dulić V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 1991 66 : 1197 206.
40. Ren S, Rollins BJ. Cyclin C/Cdk3 promotes Rb-dependent G0 exit. Cell 2004 117 : 239 51.
41. Shimizu Y, Miyazaki M, Shimizu H, Ito H, Nakagawa K, Ambiru S, Yoshidome H, Nakajima N. Beneficial effects of arterialization of the portal vein on extended hepatectomy. Br J Surg 2000 87 : 784 9.
42. Oda H, Miyake H, Iwata T, Kusumoto K, Rokutan K, Tashiro S. Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats. J Gastrointest Surg 2002 6 : 464 72.
43. Fukuchi T, Hirose H, Onitsuka A, Hayashi M, Senga S, Imai N, Shibata M, Yamauchi K, Futamura N, Sumi Y. Effects of portal-systemic shunt following 90% partial hepatectomy in rats. J Surg Res 2000 89 : 126 31.