Hippocampal mossy fiber sprouting and Cdk5/p35 expressions in the pentylenetetrazol kindling rat model

Journal of Central South University (Medical Sciences)

Volumn 33, Issue 12, 2008, Pages 1101-1107

  Tian, Fa Fa ^a   Guo, Ting Hui ^a,b   Chen, Jin Mei ^a,c   Ma, Yun Feng ^a,d   Zeng, Chang ^a   Li, Feng Rong ^a   Wang, Xin Hua ^a   Fu, Jing Jing ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c Shanghai Putuo District People's Hospital   (China)

^d Sanbofuxing Brain Hospital   (China)

Author keywords

Cyclin dependent kinase 5; Kindling model; Mossy fiber sprouting; Pentylenetetrazole

Indexed keywords

CDK5 PROTEIN, RAT; CDK5R PROTEIN, RAT; CYCLIN DEPENDENT KINASE 5; MESSENGER RNA; PENTETRAZOLE; PHOSPHOTRANSFERASE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; EPILEPSY; GENETICS; HIPPOCAMPAL MOSSY FIBER; KINDLING; MALE; METABOLISM; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CYCLIN-DEPENDENT KINASE 5; EPILEPSY; KINDLING, NEUROLOGIC; MALE; MOSSY FIBERS, HIPPOCAMPAL; PENTYLENETETRAZOLE; PHOSPHOTRANSFERASES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 58449099641     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Bernard P B, Macdonald D S, Gill D A, et al. Hippocampal mossy fiber sprouting and elevated trkB receptor expression following systemic administration of low dose domoic acid during neonatal development[J]. Hippocampus,2007,17(11):1121-1133.
2. Cross D J, Cavazos J E. Synaptic reorganization in subiculum and CA3 after early-life status epilepticus in the kainic acid rat model[J]. Epilepsy Res,2007,73(2):156-65.
3. Wang J, Liu S, Fu Y, et al. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors[J]. Nat Neurosci,2003,6(10): 1039-1047.
4. Tomizawa K, Ohta J, Matsushita M, et al. Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q type voltage-dependent calcium channel activity[J]. J Neurosci,2002,22(7):2590-2597.
5. TIAN Fa-fa, GUO Ting-hui, CHEN Jin-mei, et al. Change of mossy fiber sprouting in hippocampus of pentylenetetrazole kindling rats[J]. Journal of Central South University. Medical Sciences,2007,32(6):1026-1030.
6. Holmes G L, Gaiarsa J L, Chavassus-Au-Louis N, et al. Consequences of neonatal seizures in the rat: morphological and behavioral effects[J]. Ann Neurol,1998,44(6):845-857.
7. Coulter D A. Chronic epileptogenic cellular alterations in the limbic system after status epilepticus[J]. Epilepsia,1999,40(suppl):S23-33.
8. Tomizawa K, Cai X H, Moriwaki A, et al. Involvement of cyclin-dependent kinase 5/p35 (nck5a) in the synaptic reorganization of rat hippocampus during kindling progression[J]. Jpn J Physiol,2000,50(5):525-532.
9. Bibb J A, Nishi A, O'Callaghan JP, et al. Phosphorylation of protein phosphatase inhibitor-1 by Cdk5[J]. J Biol Chem,2001,276(17):14490-14497.
10. Morabito M A, Sheng M, Tsai L H. Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons[J]. J Neurosci,2004,24(4):865-876.