Human herpes virus 6 in archival cardiac tissues from children with idiopathic dilated cardiomyopathy or congenital heart disease

Journal of Clinical Pathology

Volumn 62, Issue 1, 2009, Pages 80-83

  Comar, M ^a,d   D'Agaro, P ^a   Campello, C ^a   Poli, A ^b   Breinholt III, J P ^c   Towbin, J A ^c   Vatta, M ^c  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c TEXAS CHILDREN S HOSPITAL   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ADENOVIRUS; ARTICLE; CHILD; CLINICAL ARTICLE; CONGENITAL HEART DISEASE; CONGESTIVE CARDIOMYOPATHY; CYTOMEGALOVIRUS; ENTEROVIRUS; EPSTEIN BARR VIRUS; GENOTYPE; HEART TRANSPLANTATION; HERPES; HUMAN; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN TISSUE; PARVOVIRUS; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; VIRUS DETECTION; VIRUS LOAD;

ADOLESCENT; CARDIOMYOPATHY, DILATED; CHILD; CHILD, PRESCHOOL; HEART; HEART DEFECTS, CONGENITAL; HERPESVIRUS 6, HUMAN; HUMANS; INFANT; RETROSPECTIVE STUDIES; ROSEOLOVIRUS INFECTIONS; TISSUE BANKS; VIRAL LOAD;

EID: 58349121418     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2008.059568     Document Type: Article

References (30)

1. Magnani JW, Dec GW. Myocarditis: current trends in diagnosis and treatment. Circulation 2006;113:876-90.
2. Kuhl U, Pauschinger M, Seeberg B, et al. Viral persistence in the myocardium is associated with progressive cardiac dysfunction. Circulation 2005;112:1965-70.
3. Vallbracht KB, Schwimmbeck PL, Kuhl U, et al. Differential aspects of endothelial function of the coronary microcirculation considering myocardial virus persistence, endothelial activation, and myocardial leukocyte infiltrates. Circulation 2005;111:1784-91.
4. Shirali GS, Ni J, Chinnock RE, et al. Association of viral genome with graft loss in children after cardiac transplantation. N Engl J Med 2001;344:1498-503.
5. Bowies NE, Ni J, Kearney DL, et al. Detection of viruses in myocardial tissues by polymerase chain reaction. Evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 2003;42:466-72.
6. Pauschinger M, Bowles NE, Fuentes-Garcia FJ, et al. Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. Circulation 1999;99:1348- 54.
7. Why HJ, Meany BT, Richardson PJ, et al. Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy. Circulation 1994;89:2582-9.
8. Donoso Mantke O, Nitsche A, Meyer R, et al. Analysing myocardial tissue from explanted hearts of heart transplant recipients and multi-organ donors for the presence of parvovirus B19 DNA. J Clin Virol 2004;31:32-9.
9. Francalanci P, Chance JL, Vatta M, et al. Cardiotropic viruses in the myocardium of children with end-stage heart disease. J Heart Lung Transplant 2004;23:1046-52.
10. Kuhl U, Pauschinger M, Noutsias M, et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction. Circulation 2005;111:887-93.
11. Mahrholdt H, Wagner A, Deluigi CC, et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation 2006;114:1581-90.
12. Fukae S, Ashizawa N, Morikawa S, et al. A fatal case of fulminant myocarditis with human herpesvirus-6 infection. Intern Med 2000;39:632-6.
13. Rohayem J, Dinger J, Fischer R, et al. Fatal myocarditis associated with acute parvovirus B19 and human herpesvirus 6 coinfection. J Clin Microbiol 2001;39:4585-7.
14. Yoshikawa T, Ihira M, Suzuki K, et al. Fatal acute myocarditis in an infant with human herpesvirus 6 infection. J Clin Pathol 2001;54:792-5.
15. Martin AB, Webber S, Fricker FJ, et al. Acute myocarditis. Rapid diagnosis by PCR in children. Circulation 1994;90:330-9.
16. Comar M, D'Agaro P, Horejsh D, et al. Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. J Clin Microbiol 2005;43:2002-3.
17. Caruso A, Favilli F, Rotola A, et al. Human herpesvirus-6 modulates RANTES production in primary human endothelial cell cultures. J Med Virol 2003;70:451-8.
18. Grivel JC, Santoro F, Chen S, et al. Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. J Virol 2003;77:8280-9.
19. Aretz HT, Billingham ME, Edwards WD, et al. Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1987;1:3-14.
20. Menegazzi P, Galvan M, Rotola A, et al. Temporal mapping of transcripts in human herpesvirus-7. J Gen Virol 1999;80:2705-12.
21. Mirandola P, Menegazzi P, Merighi S, et al. Temporal mapping of transcripts in herpesvirus 6 variants. J Virol 1998;72:3837-44.
22. Boutolleau D, Duros C, Bonnafous P, et al. Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol 2006;35:257-63.
23. Caselli E, Galvan M, Santoni F, et al. Human herpesvirus-8 (Kaposi's sarcomaassociated virus) 0RF50 increases in vitro cell susceptibility to human immunodeficiency virus type 1 infection. J Gen Virol 2003;84:1123-31.
24. Harrell FE Jr, Lee KL, Mark DB. Multivariate prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996;15:361-87.
25. Maekawa Y, Ouzounian M, Opavsky MA, et al. Connecting the missing link between dilated cardiomyopathy and viral myocarditis: virus, cytoskeleton, and innate immunity. Circulation 2007;115:5-8.
26. Bultmann BD, Klingel K, Sotlar K, et al. Parvovirus B19: a pathogen responsible for more than hematologic disorders. Virchows Arch 2003;442:8-17.
27. Krueger GR, Ablashi DV. Human herpesvirus-6: a short review of its biological behavior. Intervirology 2003;46:257-69.
28. Hall CB, Caserta MT, Schnabel KC, et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr 2004;145:472-7.
29. Caserta MT, Hall CB, Schnabel K, et al. Human herpesvirus (HHV)-6 and HHV-7 infections in pregnant women. J Infect Dis 2007;196:1296-303.
30. Bultmann BD, Klingel K, Nabauer M, et al. High prevalence of viral genomes and inflammation in peripartum cardiomyopathy. Am J Obstet Gynecol 2005;193:363-5.