Differential aspects of endothelial function of the coronary microcirculation considering myocardial virus persistence, endothelial activation, and myocardial leukocyte infiltrates

Circulation

Volumn 111, Issue 14, 2005, Pages 1784-1791

  Vallbracht, Katja B ^a   Schwimmbeck, Peter L ^a   Kühl, Uwe ^a   Rauch, Ursula ^a   Seeberg, Bettina ^a   Schultheiss, Heinz Peter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cardiomyopathy; Endothelium; Inflammation; Microcirculation; Viruses

Indexed keywords

ACETYLCHOLINE; ADENOSINE;

ADENOVIRUS; ADULT; ANGIOCARDIOGRAPHY; ARTERY DIAMETER; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL REACTIVITY; CALCULATION; CARDIOMYOPATHY; CELL INFILTRATION; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENTEROVIRUS; FEMALE; HEART CATHETERIZATION; HEART EJECTION FRACTION; HEART MUSCLE BIOPSY; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOLOGY; INTERMETHOD COMPARISON; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MYOCARDITIS; PARVOVIRUS; PERSISTENT VIRUS INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE; VASODILATATION; VELOCITY;

ADULT; BIOPSY; CARDIOMYOPATHIES; CHEMOTAXIS, LEUKOCYTE; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; ECHOCARDIOGRAPHY, DOPPLER; ENDOTHELIUM, VASCULAR; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROCIRCULATION; MIDDLE AGED; POLYMERASE CHAIN REACTION; STROKE VOLUME; VIRAL LOAD;

EID: 17144409396     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000160863.30496.9B     Document Type: Article

References (35)

1. Vallbracht KB, Schwimmbeck PL, Seeberg B, Kuhl U, Schultheiss HP. Endothelial dysfunction of peripheral arteries in patients with immunohistologically confirmed myocardial inflammation correlates with endothelial expression of human leukocyte antigens and adhesion molecules in myocardial biopsies. J Am Coll Cardiol. 2002;40:515-520.
2. Hingorani AD, Cross J, Kharbanda RK, Mullen MJ, Bhagat K, Taylor M, Donald AE, Palacios M, Griffin GE, Deanfield JE, MacAllister RJ, Vallance P. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation. 2000;102:994-999.
3. Dhillon R, Clarkson P, Donald AE, Powe AJ, Nash M, Novelli V, Dillon MJ, Deanfield JE. Endothelial dysfunction late after Kawasaki disease. Circulation. 1996;94:2103-2106.
4. Raza K, Thambyrajah J, Townend JN, Exley AR, Hortas C, Filer A, Carruthers DM, Bacon PA. Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function: lessons for atherosclerotic disease? Circulation. 2000;102:1470-1472.
5. Fichtescherer S, Rosenberger G, Walter DH, Breuer S, Dimmeler S, Zeiher AM. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation. 2000;102:1000-1006.
6. Wang P, Ba ZF, Chaudry IH. Administration of tumor necrosis factor alpha in vivo depresses endothelium dependent vasorelaxation. Am J Physiol. 1994;266:H2535-H2541.
7. Wildhirt SM, Weis M, Schulze C, Conrad N, Rieder G, Enders G, Hoepp C, von Scheidt W, Reichart B. An association between microvascular endothelial dysfunction, transcardiac nitric oxide production and proinflammatory cytokines after heart transplantation in humans. Transpl Int. 2000;13(suppl 1):S228-S234.
8. Pauschinger M, Doerner A, Kuehl U, Schwimmbeck PL, Poller W, Kandolf R, Schultheiss HP. Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. Circulation. 1999;99:889-895.
9. Kuehl U, Pauschinger M, Bock T, Klingel K, Schwimmbeck CP, Seeberg B, Krautwurm L, Poller W, Schultheiss HP, Kandolf R. Parvovirus B19 infection mimicking acute myocardial infarction. Circulation. 2003;108:945-950.
10. Burgert HG, Maryanski JL, Kvist S. E3/19 k protein of adenovirus type 2 inhibits lysis of cytolytic T lymphocytes by blocking cell-surface expression of histocompatibility class 1 antigens. Proc Natl Acad Sci U S A. 1987;84:1356-1360.
11. Vallbracht KB, Schwimmbeck PL, Kuehl U, Seeberg B, Schultheiss HP. Endothelium-dependent flow-mediated vasodilation of systemic arteries is impaired in patients with myocardial virus persistence. Circulation. 2004;110:2938-2945.
12. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336:973-979.
13. Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, Mabuchi N, Sawaki M, Kinoshita M. Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol. 1998;31:391-398.
14. Schaechinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899-1906.
15. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101:948-954.
16. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Hour KR, Quyyumi AA. Prognostic value of coronary vascular endothelial function. Circulation. 2002;106:653-658.
17. Davis SF, Yeung AC, Meredith IT, Charbonneau F, Ganz P, Selwyn AP, Anderson TJ. Early endothelial dysfunction predicts the development of transplant coronary artery disease at 1 year posttransplant. Circulation. 1996;93:457-462.
18. Weis M, Hartmann A, Olbrich HG, Hor G, Zeiher AM. Prognostic significance of coronary flow reserve on left ventricular ejection fraction in cardiac transplant recipients. Transplantation. 1998;65:103-108.
19. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk-factors and their interaction. J Am Coll Cardiol. 1994;24:1468-1474.
20. Reddy KG, Nair RN, Sheehan HM, Hodgson JM. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk-factors for atherosclerosis. J Am Coll Cardiol. 1994;23:833-843.
21. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, Deanfield JE. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88(pt 1):2149-2155.
22. Kubo SH, Rector TS, Bank AJ, Williams RE, Heifetz SM. Endothelium-dependent vasodilation is attenuated in patients with heart failure. Circulation. 1991;84:1589-1596.
23. Hornig B, Arakawa N. Haussmann D, Drexler H. Differential effects of quinaprilat on endothelial function of conduit arteries in patients with chronic heart failure. Circulation. 1998;98:2842-2848.
24. Gokce N, Holbrook M, Hunter LM, Palmisano J, Vigalok E, Keaney JF Jr, Vita JA. Acute effects of vasoactive drug treatment on brachial artery reactivity. J Am Coll Cardiol. 2002;40:761-765.
25. Kühl U, Noutsias M, Seeberg B, Schultheiss HP. Immunohistological evidence for a chronic intramyocardial inflammatory process in dilated cardiomyopathy. Heart. 1996;75:295-300.
26. Noutsias M, Seeberg B, Schultheiss HP, Kuhl U. Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy. Circulation. 1999;99:2124-2131.
27. Pauschinger M, Bowles NE, Fuentes-Garcia FJ, Pham V, Kuhl U, Schwimmbeck PL, Schultheiss HP, Towbin JA. Detection of adenoviral genome in adult patients with idiopathic left ventricular dysfunction. Circulation. 1999;99:1348-1354.
28. Smith LM, Sanders JZ, Kaiser RJ, Hughes P, Dodd C, Connell CR, Heiner C, Kent SB, Hood LE. Fluorescence detection in automated DNA sequence analysis. Nature. 1986;321:674-679.
29. Erdman DD, Durigon EL, Wang QY, Anderson LJ. Genetic diversity of human parvovirus B19: sequence analysis of the VP1/VP2 gene from multiple isolates. J Gen Virol. 1996;77:2767-2774.
30. Chomczynski P, Sacchi N. Single step method of RNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
31. Rotbart HA. PCR amplification of enteroviruses. In: PCR Protocols: A Guide to Methods and Applications. New York, NY: Academic Press, Inc; 1990:372-377.
32. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046-1051.
33. Deleted in proof.
34. Vita JA, Treasure CB, Nabel EG, McLenachan JM, Fish RD, Yeung AC, Vekshtein VI, Selwyn AP, Ganz P. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 1990;81:491-497.
35. Kern MJ, Bach RG, Mechem CJ, Caracciolo EA, Aguirre FV, Miller LW, Donohue TJ. Variations in normal coronary vasodilatory reserve stratified by artery, gender, heart transplantation and coronary artery disease. J Am Coll Cardiol. 1996;28:1154-1160.