The effect of processing parameters on pharmaceutical tablet properties

Powder Technology

Volumn 189, Issue 2, 2009, Pages 276-284

  Sinka, I C ^a   Motazedian, F ^a   Cocks, A C F ^b   Pitt, K G ^c  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Die fill; Friability; Shoe die system; Strength; Tablet structure; Tableting

Indexed keywords

FRIABILITY; SHOE-DIE SYSTEM; STRENGTH; TABLET STRUCTURE; TABLETING;

COMPACTION; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC RADIOGRAPHY; DRUG DELIVERY; MACHINERY; MEDICAL IMAGING; POWDERS; PRESSES (MACHINE TOOLS); SHOE MANUFACTURE; TOMOGRAPHY;

DIES;

ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DENSITY; FLOW MEASUREMENT; FRICTION; GRAVITY; POWDER; PROCESSING; QUANTITATIVE ANALYSIS; SIMULATOR; SUCTION; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET MACHINE; TABLET PROPERTY; VELOCITY;

EID: 58349117904     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.04.020     Document Type: Article

References (21)

1. Sinka I.C., Schneider L.C.R., and Cocks A.C.F. Measurement of the flow properties of powders with special reference to die fill. International Journal of Pharmaceutics 280 1-2 (2004) 27-38
2. Wu C.Y., Dihoru L., and Cocks A.C.F. The flow of powder into simple and stepped dies. Powder Technology 134 (2003) 24-39
3. Schneider L.C.R., Sinka I.C., and Cocks A.C.F. Characterisation of the flow behaviour of pharmaceutical powders using a model die-shoe filling system. Powder Technology 173 (2007) 59-71
4. Jackson S., Sinka I.C., and Cocks A.C.F. The effect of suction during die fill on a rotary tablet press. European Journal of Pharmaceutics and Biopharmaceutics 65 2 (2007) 253-256 Short communication
5. Pitt K.G., and Sinka I.C. Chapter 16: Tableting. In: Salman A.D., Hounslow M.J., and Seville J.P.K. (Eds). Granulation (Handbook of Powder Technology Vol. 11 (2007), Elsevier B.V. 735-778
6. Rippie E.G., and Danielson D.W. Viscoelastic stress/strain behavior of pharmaceutical tablets: analysis during unloading and post compression periods. Journal of Pharmaceutical Sciences 70 (1981) 476-482
7. Timoshenko S.P., and Goodier J.N. Theory of Elasticity (1970), McGraw-Hill, New York
8. Procopio A., Zavaliangos A., and Cunningham J.C. Analysis of the diametrical compression test and its applicability to plastically deforming materials. Journal of Materials Science 38 (2003) 3629-3639
9. Sinka I.C., Pitt K.G., and Cocks A.C.F. Chapter 22: The strength of pharmaceutical tablets. In: Salman A.D., Hounslow M.J., and Ghadiri M. (Eds). Particle Breakage. Handbook of Powder Technology vol. 12 (2007), Elsevier 941-970
10. Joiris E., Di Martino P., Berneron C., Guyot-Hermann A.M., and Guyot J.G. Compression behavior of orthorhombic paracetamol. Pharmaceutical Research 15 (1998) 1122-1130
11. Sinka I.C., Cunningham J.C., and Zavaliangos A. Experimental characterization and numerical simulation of die wall friction in pharmaceutical powder compaction. Proc. PM2TEC 2001 International Conference on Powder Metallurgy & Particulate Materials, 13-17 May, New Orleans, Louisiana, USA 1 (2001). 1-878954-82-2 46-60
12. Michrafy A., Ringenbacher D., and Tchoreloff P. Modelling the compaction behaviour of powders: application to pharmaceutical powders. Powder Technology 127 (2002) 257-266
13. Sinka I.C., Cunningham J.C., and Zavaliangos A. The effect of wall friction in the compaction of pharmaceutical tablets with curved faces: a validation study of the Drucker-Prager Cap model. Powder Technology 133 1-3 (2003) 33-43
14. Sinka I.C., Cunningham J.C., and Zavaliangos A. Analysis of tablet compaction. Part 2 - Finite element analysis of density distribution in convex tablets. Journal of Pharmaceutical Sciences 93 8 (2004) 2040-2052
15. Wu C.-Y., Ruddy O.M., Bentham A.C., Hancock B.C., Best S.M., and Elliott J.A. Modelling the mechanical behaviour of pharmaceutical powders during compaction. Powder Technology 152 (2005) 107-117
16. Train D. Transmission of forces through a powder mass during the process of pelleting. Transactions of the Institution of Chemical Engineers 35 (1957) 258-266
17. Lannutti J.J. Characterisation and control of compact microstructure. MRS Bulletin 22 12 (1997) 38-44
18. Nebgen G., Gross D., Lehmann V., and Müller F. 1H-NMR microscopy of tablets. Journal of Pharmaceutical Sciences 84 3 (1995) 283-291
19. Sinka I.C., Burch S.F., Tweed J.H., and Cunningham J.C. Measurement of density variations in tablets using X-ray computed tomography. International Journal of Pharmaceutics 271 1-2 (2004) 215-224
20. Eiliazadeh B., Pitt K., and Briscoe B. Effects of punch geometry on powder movement during pharmaceutical tabletting processes. International Journal of Solids and Structures 41 21 (2004) 5967-5977
21. Djemai A., and Sinka I.C. Nuclear magnetic resonance imaging of density distributions in tablets. International Journal of Pharmaceutics 319 1-2 (2006) 55-62