Metabonomic profile of urine from rats administrated with different treatment period of rifampin

Acta Academiae Medicinae Sinicae

Volumn 30, Issue 6, 2008, Pages 696-702

  Liao, Yan ^b   Peng, Shuang Qing ^a   Yan, Xian Zhong ^a   Chen, He Bing ^a   Zhang, Li Shi ^c  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Hepatotoxicity; Metabonomic; Nuclear magnetic resonance; Pattern recognition; Rifampin

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CITRIC ACID; GLUCOSE; RIFAMPICIN; TAURINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG URINE LEVEL; ENERGY METABOLISM; GLUCOSE METABOLISM; GLUCOSE URINE LEVEL; HISTOPATHOLOGY; LIPID METABOLISM; LIVER TOXICITY; LONG TERM EXPOSURE; MALE; METABOLOMICS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TOXICITY TESTING; URINALYSIS;

ANIMALS; ANTIBIOTICS, ANTITUBERCULAR; BLOOD CHEMICAL ANALYSIS; DRUG TOXICITY; INFUSIONS, PARENTERAL; LIVER; MALE; METABOLOMICS; MODELS, ANIMAL; RANDOM ALLOCATION; RATS; RATS, WISTAR; RIFAMPIN; URINE;

EID: 58349107072     PISSN: 1000503X     EISSN: None     Source Type: Journal    
DOI: 10.3881/j.issn.1000-503X.2008.06.015     Document Type: Article

References (16)

1. Nicholson LK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data [J]. Xenobiotica, 1999, 29(11):1181-1189.
2. Lindon JC, Holmes E, Nicholson JK. Pattern recognition methods and applications in biomedical magnetic resonance [J]. Prog NMRS, 2001, 39(1):1-40.
3. Nicholson JK, Connelly J, Lindon JC, et al. Metabonomics: a platform for studying drug toxicity and gene function [J]. Nat Rev Drug Discov, 2002, 1(2):153-161.
4. Dossing M, Wilcke JTR, Askgaard DS, et al. Liver injury during antituberculosis treatment: an 11-year study [J]. Tuberc Lung Dis, 1996, 77(4):335-340.
5. Sinder DE, Caras GJ. Isoniazid-associated hepatitis deaths: a review of available information [J]. Am Reu Respir Dis, 1992, 145 (2 Pt1):494-497.
6. Chinese source.
7. Nicholson JK, Buckingham MJ, Ssdler PJ. High resolution proton NMR studies of vertebrate blood and plasma [J]. Biochem J, 1983, 211(3):605-615.
8. Gavaghan CL, Holmes E, Lenz E, et al. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences; application to the C57BL10J and Alpk: ApfCD mouse [J]. FEBS Lett, 2000, 484(3):169-174.
9. Azmi J, Griffin JL, Antti H, et al. Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data [J]. Analyst, 2002, 127(2):271-276.
10. Nicholls AW, Holmes E, Lindon JC, et al. Metabonomic investigations into hydrazine toxicity in the rat [J]. Chem Res Toxicol, 2001, 14(8):975-987.
11. Robertson DG, Reily MD, Sigler RE, et al. Metabonomics: evaluation of nuclear magneuc resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants [J]. Toxicol Sci, 2000, 57(2):326-337.
12. Jaeschke H, Gores GJ, Cederbaum AI, et al. Mechanisms of hepatotoxicity [J]. Toxicol Sci, 2002, 65(2):166-176.
13. Griffin JL, Bollard ME. Metabonomics: its potential as a tool in toxicology for safety assessment and data integration [J]. Curr Drug Metab, 2004, 5(5):389-398.
14. Lenz EM, Wilson ID. Analytical strategies in metabonomics [J]. J Proteome Res, 2007, 6(2):443-458.
15. Robertson DG, Reily MD, Baker JD. Metabonomics in pharmaceutical discovery and development [J]. J Proteome Res, 2007, 6(2):526-539.
16. Yuan KL, Kong HW, Guan YF, et al. A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile [J]. J Chromatogr B, 2007, 850 (1-2): 236-240.