Advances and challenges in basic and translational research on clusterin

Cancer Research

Volumn 69, Issue 2, 2009, Pages 403-406

  Trougakos, Ioannis P ^a,d   Djeu, Julie Y ^b   Gonos, Efstathios S ^a   Boothman, David A ^c  

^a UNIVERSITY OF ATHENS   (Greece)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d INSTITUTE OF BIOLOGY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CLUSTERIN; CYTOTOXIC AGENT; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; SMALL INTERFERING RNA; STAT PROTEIN; TOLL LIKE RECEPTOR; VANADYL SULFATE; VASCULOTROPIN A;

APOPTOSIS; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONFERENCE PAPER; DOUBLE STRANDED DNA BREAK; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC CODE; HUMAN; LUNG ADENOCARCINOMA; METASTASIS; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; TUMOR PROMOTION; UPREGULATION;

ANIMALS; CLUSTERIN; HUMANS; NEOPLASMS;

EID: 58349092086     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-2912     Document Type: Conference Paper

References (11)

1. Pucci S, Bonanno E, Pichiorri F, et al. Modulation of different clusterin isoforms in human colon tumorigenesis. Oncogene 2004;23:2298-304.
2. Redondo M, Villar E, Torres-Munoz J, et al. Overexpression of clusterin in human breast carcinoma. Am J Pathol 2000;157:393-9.
3. Shannan B, Seifert M, Leskov K, et al. Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death Differ 2006;13:12-9.
4. Chi KN, Siu LL, Hirte H, et al. A phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin Cancer Res 2008;14:833-9.
5. 2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells. Cell Death Differ 2005;12:101-4.
6. Leskov KS, Klokov DY, Li J, et al. Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem 2003;278:11590-600.
7. Criswell TL, Beman M, Arakis S, et al. Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a prosurvival factor. J Biol Chem 2005;280:14212-21.
8. Trougakos IP, Gonos ES. Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res 2006;40:1324-34.
9. Klokov D, Criswell T, Leskov KS, et al. IR-inducible clusterin gene expression: a protein with potential roles in ionizing radiation-induced adaptive responses, genomic instability, and bystander effects. Mutat Res 2004;568:97-110.
10. Sallman DA, Chen X, Zhong B, et al. Clusterin mediates TRAIL resistance in prostate tumor cells. Mol Cancer Ther 2007;6:2938-47.
11. Thomas-Tikhonenko A, Viard-Leveugle I, Dews M, et al. Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. Cancer Res 2004;64:3126-36.