Neuro-Behçet's disease: epidemiology, clinical characteristics, and management

The Lancet Neurology

Volumn 8, Issue 2, 2009, Pages 192-204

  Al Araji, Adnan ^a   Kidd, Desmond P ^b  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; INFLIXIMAB; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

BEHCET DISEASE; BLOOD TESTIS BARRIER; CEREBROSPINAL FLUID; COMPUTER ASSISTED TOMOGRAPHY; EPILEPSY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MENINGISM; MENINGOENCEPHALITIS; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHLEBOGRAPHY; PREVALENCE; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE;

BEHCET SYNDROME; HUMANS; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES;

EID: 58249144864     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(09)70015-8     Document Type: Review

References (150)

1. Behçet H. Über residivierende, aphtöse durch ein Virus verursachtes Geschwüre am Mund, am Auge und an der Genitalien. Derm Wschr 105 (1937) 1152-1157
2. Sakane T., Takeno M., Suzuki N., and Inaba G. Behçet's disease. N Engl J Med 341 (1999) 1284-1291
3. Verity D.H., Wallace G.R., Vaughan R.W., and Stanford M.R. Behçet's disease: from Hippocrates to the third millennium. Br J Ophthalmol 87 (2003) 1175-1183
4. Yazici H., Fresko I., and Yurdakul S. Behçet's syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol 3 (2007) 148-155
5. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 335 (1990) 1078-1080
6. Kural-Seyahi E., Fresko I., Seyahi N., et al. The long-term mortality and morbidity of Behçet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center. Medicine (Baltimore) 82 (2003) 60-76
7. Hentati F., Fredj M., Gharbi N., and Hamida M. Clinical and biological aspects of neuro-Behçet's in Tunisia. In: Wechsler B., and Godeau P. (Eds). Behçet's disease (1993), Elsevier, Amsterdam 415-418
8. Bohlega S., AlKawi M.Z., Omer S., et al. Neuro-Behçet's: clinical syndromes and prognosis. In: Wechsler B., and Godeau P. (Eds). Behçet's disease (1993), Elsevier, Amsterdam 429-433
9. Nakamura Y., Takahashi M., Ueyama K., et al. Magnetic resonance imaging and brain-stem auditory evoked potentials in neuro-Behçet's disease. J Neurol 241 (1994) 481-486
10. Farah S., Al-Shubaili A., Montaser A., et al. Behçet's syndrome: a report of 41 patients with emphasis on neurological manifestations. J Neurol Neurosurg Psychiatry 64 (1998) 382-384
11. Kidd D., Steuer A., Denman A.M., and Rudge P. Neurological complications of Behçet's syndrome. Brain 122 (1999) 2183-2194
12. Akman-Demir G., Serdaroglu P., and Tasçi B. Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients. The Neuro-Behçet Study Group. Brain 122 (1999) 2171-2182
13. Al-Fahad S., and Al-Araji A. Neuro-Behçet's disease in Iraq: a study of 40 patients. J Neurol Sci 170 (1999) 105-111
14. Siva A., Kantarci O.H., Saip S., et al. Behçet's disease: diagnostic and prognostic aspects of neurological involvement. J Neurol 248 (2001) 95-103
15. Lee S.H., Yoon P.H., Park S.J., and Kim D.I. MRI findings in neuro-Behçet's disease. Clin Radiol 56 (2001) 485-494
16. Yücesan C., Isikay C.T., Ozay E., Aydin N., and Mutluer N. The clinical involvement patterns of neuro-Behçet's disease. Eur J Neurol 8 (2001) 92
17. Lannuzel A., Lamaury I., Charpentier D., and Caparros-Lefebvre D. Neurological manifestations of Behçet's disease in a Caribbean population: clinical and imaging findings. J Neurol 249 (2002) 410-418
18. Sbaï A., Wechsler B., Duhaut P., et al. Neuro-Behçet's disease (isolated cerebral thrombophlebitis excluded). Clinical pattern, prognostic factors, treatment and long term follow-up. Adv Exp Med Biol 528 (2003) 371-376
19. Al-Araji A., Sharquie K., and Al-Rawi Z. Prevalence and patterns of neurological involvement in Behçet's disease: a prospective study from Iraq. J Neurol Neurosurg Psychiatry 74 (2003) 608-613
20. Turker H., Terzi M., Bayrak O., Cengiz N., Onar M., and Us O. Visual evoked potentials in differential diagnosis of multiple sclerosis and neurobehçet's disease. Tohoku J Exp Med 216 (2008) 109-116
21. Borhani-Haghighi A., Samangooie S., Ashjazadeh N., et al. Neurological manifestations of Behçet's disease. Saudi Med J 27 (2006) 1542-1546
22. Lo Monaco A., La Corte R., Caniatti L., Borrelli M., and Trotta F. Neurological involvement in North Italian patients with Behçet disease. Rheumatol Int 26 (2006) 1113-1119
23. Barros R., Santos E., Moreira B., et al. Clinical characterization and pattern of neurological involvement of Behçet's disease in fifteen Portuguese patients. Clin Exp Rheumatol 24 suppl 42 (2007) S31
24. Joseph F.G., and Scolding N.J. Neuro-Behçet's disease in caucasians: a study of 22 patients. Eur J Neurol 14 (2007) 174-180
25. Houman M.H., Neffati H., Braham A., et al. Behçet's disease in Tunisia. Demographic, clinical and genetic aspects in 260 patients. Clin Exp Rheumatol 25 suppl 45 (2007) S58-S64
26. Tursen U., Gurler A., and Boyvat A. Evaluation of clinical findings according to sex in 2313 Turkish patients with Behçet's disease. Int J Dermatol 42 (2003) 346-351
27. Serdaroglu P., Yazici H., Ozdemir C., Yurdakul S., Bahar S., and Aktin E. Neurological involvement in Behçet's syndrome-a prospective study. Arch Neurol 46 (1989) 265-269
28. Ashjazadeh N., Haghighi A.B., Samangooie S., and Moosavi H. Neuro-Behçet's disease: a masquerader of multiple sclerosis. A prospective study of neurologic manifestations of Behçet's disease in 96 Iranian patients. Exp Mol Pathol 74 (2003) 17-22
29. Krause I., Uziel Y., Guedj D., et al. Childhood Behçet's disease: clinical features and comparison with adult-onset disease. Rheumatology (Oxford) 38 (1999) 457-462
30. Karincaoglu Y., Borlu M., Toker S.C., et al. Demographic and clinical properties of juvenile-onset Behçet's disease: a controlled multicenter study. J Am Acad Dermatol 58 (2008) 579-584
31. Treudler R., Orfanos C.E., and Zouboulis C.C. Twenty-eight cases of juvenile-onset Adamantiades-Behçet disease in Germany. Dermatology 199 (1999) 15-19
32. Wechsler B., Dell'Isola B., Vidailhet M., et al. MRI in 31 patients with Behçet's disease and neurological involvement: prospective study with clinical correlation. J Neurol Neurosurg Psychiatry 56 (1993) 793-798
33. Lueck C.J., Pires M., McCartney A.C., and Graham E.M. Ocular and neurological Behçet's disease without orogenital ulceration?. J Neurol Neurosurg Psychiatry 56 (1993) 505-508
34. Al Kawi M.Z., Bohlega S., and Banna M. MRI findings in neuro-Behçet's disease. Neurology 41 (1991) 405-408
35. Serdaroglu P. Behçet's disease and the nervous system. J Neurol 245 (1998) 197-205
36. Haghighi A.B., Pourmand R., and Nikseresht A.R. Neuro-Behçet disease. A review. Neurologist 11 (2005) 80-89
37. Hirohata S. Histopathology of central nervous system lesions in Behçet's disease. J Neurol Sci 267 (2008) 41-47
38. Hadfield M.G., Aydin F., Lippman H.R., Kubal W.S., and Sanders K.M. Neuro-Behçet's disease. Clin Neuropathol 15 (1996) 249-255
39. Arai Y., Kohno S., Takahashi Y., Miyajima Y., and Tsutusi Y. Autopsy case of neuro-Behçet's disease with multifocal neutrophilic perivascular inflammation. Neuropathology 26 (2006) 579-585
40. Scardamaglia L., Desmond P.M., Gonzales M.F., Bendrups A., Brotdmann A., and Kay T.W.H. Behçet's disease with cerebral vasculitis. Int Med J 31 (2001) 560-561
41. Koçer N., Islak C., Siva A., et al. CNS involvement in neuro-Behçet syndrome: an MR study. Am J Neuroradiol 20 (1999) 1015-1024
42. Kizilkilic O., Albayram S., Adaletli I., Ak H., Islak C., and Kocer N. Endovascular treatment of Behçet's disease-associated intracranial aneurysms: report of two cases and review of the literature. Neuroradiology 45 (2003) 328-334
43. Buge A., Vincent D., Rancurel G., Dechy H., Dorra M., and Betourne C. Behçet's diseases with multiple intracranial arterial aneurysms. Rev Neurol (Paris) 143 (1987) 832-835
44. Chen Y., Stanford M.R., Wallace G.R., Vaughan R.W., Kondeatis E., and Fortune F. Factor V leiden mutation does not correlate with retinal vascular occlusion in white patients with Behçet's disease. Br J Ophthalmol 87 (2003) 1048-1049
45. Leiba M., Seligson U., Sidi Y., et al. Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease. Ann Rheum Dis 63 (2004) 1445-1449
46. Saruhan-Direskeneli G., Yentur S.P., Akman-Demir G., Isik N., and Serdaroglu P. Cytokines and chemokines in neuro-Behçet's disease compared to multiple sclerosis and other neurological diseases. J Neuroimmunol 145 (2003) 127-134
47. Hirohata S., Isshi K., Oguchi H., et al. Cerebrospinal fluid interleukin-6 in progressive neuro-Behçet's syndrome. Clin Immunol Immunopathol 82 (1997) 12-17
48. Fujikawa K., Aratake K., Kawakama A., et al. Successful treatment of refractory neuro-Behçet's disease with infliximab: a case report to show its efficacy by magnetic resonance imaging, transcranial magnetic stimulation and cytokine profile. Ann Rheumat Dis 66 (2007) 136-137
49. Akman-Demir G., Tuzun E., Icoz S., et al. Interleukin-6 in neuro-Behçet's disease: association with disease subsets and long-term outcome. Cytokine (2008) 10.1016/j.cyto.2008.10.007 published online Nov 14.
50. Kermode A.G., Plant G.T., MacManus D.G., Kendall B.E., Kingsley D., and Moseley I.F. Behçet's disease with slowly enlarging midbrain mass on MRI: resolution following steroid therapy. Neurology 39 (1989) 1251-1252
51. Kang D.W., Chu K., Cho J.Y., et al. Diffusion weighted magnetic resonance imaging in neuro-Behçet's disease. J Neurol Neurosurg Psychiatry 70 (2001) 412-413
52. Hiwatashi A., Garber T., Moritani T., Kinoshita T., and Westeson P.L. Diffusion weighted MR imaging of neuro-Behçet's disease: a case report. Neuroradiology 45 (2003) 468-471
53. Coban O., Bahar S., Akman-Demir G., et al. Masked assessment of MRI findings: is it possible to differentiate neuro-Behçet's disease from other central nervous system diseases?. Neuroradiology 41 (1999) 255-260
54. Inaba G. Behçet's disease. In: Vinken P.J., Bruyn G.W., and Klawans H.L. (Eds). Handbook of clinical neurology vol. 56 (1989), Elsevier, Amsterdam 593-610
55. Mascalchi M., Cosottini M., Cellerini M., Paganini M., and Arnetoli G. MRI of spinal cord involvement in Behçet's disease: case report. Neuroradiology 40 (1998) 255-257
56. Tunc R., Saip S., Siva A., and Yazici H. Cerebral venous thrombosis is associated with major vessel disease in Behçet's syndrome. Ann Rheum Dis 63 (2004) 1693-1694
57. Wechsler B., Vidaihet M., Piette J.C., et al. Cerebral venous thrombosis in Behçet's disease: clinical study and long-term follow-up of 25 cases. Neurology 42 (1992) 614-618
58. Cengiz N., Sahin M., and Onar M. Correlation of clinical, MRI and Tc-99m HMPAO SPECT findings in neuro-Behçet's disease. Acta Neurol Belg 104 (2004) 100-105
59. Huang W.S., Chiu P.Y., Kao A., Tsai C.H., and Lee C.C. Decreased cerebral blood flow in neuro-Behçet's syndrome with neuropsychiatric manifestations and normal magnetic resonance imaging-a preliminary report. J Neuroimaging 12 (2002) 355-359
60. Alema G. Behçet's disease. In: Vinken P.J., and Bruyn G.W. (Eds). tHandbook of clinical neurology (1978), North Holland Publishing, Amsterdam 475-512
61. Schotland D.L., Wolf S.M., White H.H., and Dubin H.V. Neurologic aspects of Behçet's disease. Case report and review of the literature. Am J Med 34 (1963) 544-553
62. Hirohata S. Potential new therapeutic options for involvement of central nervous system in Behçet's disease (neuro-Behçet's syndrome). Curr Rheumatol Rev 3 (2007) 297-303
63. Kikuchi H., Aramaki K., and Hirohata S. Effect of infliximab in progressive neuro-Behçet's syndrome. J Neurol Sci 272 (2008) 99-105
64. Aykutlu E., Baykan B., Serdaroglu P., Gökyigit A., and Akman-Demir G. Epileptic seizures in Behçet disease. Epilepsia 43 (2002) 832-835
65. Mead S., Kidd D., Good C., and Plant G. Behçet's syndrome may present with partial seizures. J Neurol Neurosurg Psychiatry 68 (2000) 392-393
66. Aktekin B., Doǧan E.A., Oǧuz Y., and Karaali K. Epilepsia partialis continua in a patient with Behçet's disease. Clin Neurol Neurosurg 108 (2006) 392-395
67. Akman-Demir G., Bahar S., Coban O., Tasci B., and Serdaroglu P. Cranial MRI in Behçet's disease: 134 examinations of 98 patients. Neuroradiology 45 (2003) 851-859
68. Rubinstein L.J., and Ulrich H. Meningo-encephalitis of Behçet's disease: case report with pathological findings. Brain 86 (1963) 151-160
69. Totsuka S., Hattori T., Yazaki M., Nagao K., and Mizushima S. Clinicopathologic studies on neuro-Behçet's disease. Folia Psychiatr Neurol Jpn 39 (1985) 155-166
70. Litvan I., Roig C., Rovira A., and Ruscalleda J. Behçet's syndrome masquerading as tumor. Neuroradiology 29 (1987) 103
71. Heo J.H., Lee S.T., Chu K., and Kim M. Neuro-Behçet's disease mimicking multiple brain tumors: diffusion-weighted MR study and literature review. J Neurol Sci 264 (2008) 177-181
72. Matsuo K., Yamada K., Nakajima K., and Nakagawa M. Neuro-Behçet disease mimicking brain tumor. Am J Neuroradiol 26 (2005) 650-653
73. Appenzeller S., de Castro R., de Souza Queiroz L., et al. Brain tumor-like lesion in Behçet disease. Rheumatol Int 26 (2006) 577-580
74. Schmolck H. Large thalamic mass due to neuro-Behçet disease. Neurology 65 (2005) 436
75. Kösters K., Bos M.M., Wesseling P., Smeets S.M., van der Ven A.J., and Bredie S.J. An unusual cause of a cerebral tumour in a young patient. Behçet's disease. Neth J Med 64 (2006) 152
76. Bennett D.L., McCabe D.J., Stevens J.M., Mifsud V., Kitchen N.D., and Giovannoni G. Tumefactive neuro-Behçet disease. Neurology 63 (2004) 709
77. Park J.H., Jung M.K., Bang C.O., et al. Neuro-Behçet's disease mimicking a cerebral tumor: a case report. J Korean Med Sci 17 (2002) 718-722
78. Guak T.H., Kim Y.I., Park S.M., and Kim J.S. Paroxysmal focal dystonia in neuro-Behçet by a small ipsilateral thalamic lesion. Eur Neurol 47 (2002) 183-184
79. Bogdanova D., Milanov I., and Georgiev D. Parkinsonian syndrome as a neurological manifestation of Behçet's disease. Can J Neurol Sci 25 (1998) 82-85
80. Kuriwaka R., Kunishige M., Nakahira H., et al. Neuro-Behçet's disease with chorea after remission of intestinal Behçet's disease. Clin Rheumatol 23 (2004) 364-367
81. Scouras J., and Koutroumanos J. Ischaemic optic neuropathy in Behçet's syndrome. Ophthalmologica 173 (1976) 11-18
82. Kansu T., Kirkali P., Kansu E., and Zileli T. Optic neuropathy in Behçet's disease. J Clin Neuroophthalmol 9 (1989) 277-280
83. Salvi F., Mascalchi M., Malatesta R., et al. Optic neuropathy in Behçet's disease. Report of two cases. Ital J Neurol Sci 20 (1999) 183-186
84. Nakamura T., Takahashi K., and Kishi S. Optic nerve involvement in neuro-Behçet's disease. Jpn J Ophthalmol 46 (2002) 100-102
85. Yalçindag N., Yilmaz N., Tekeli O., and Ozdemir O. Acute optic neuropathy in Behçet disease. Eur J Ophthalmol 14 (2004) 578-580
86. Voros G.M., Sandhu S.S., and Pandit R. Acute optic neuropathy in patients with Behçet's disease. Report of two cases. Ophthalmologica 220 (2006) 400-405
87. Tarzi M.D., Lightman S., and Longhurst H.J. An exacerbation of Behçet's syndrome presenting with bilateral papillitis. Rheumatology (Oxford) 44 (2005) 953-954
88. Yamauchi Y., Cruz J.M., Kaplan H.J., Goto H., Sakai J., and Usui M. Suspected simultaneous bilateral anterior ischemic optic neuropathy in a patient with Behçet's disease. Ocul Immunol Inflamm 13 (2005) 317-325
89. Mitra S., and Koul R.L. Paediatric neuro-Behçet's disease presenting with optic nerve head swelling. Br J Ophthalmol 83 (1999) 1096
90. Yesilot N., Mutlu M., Gungor O., Baykal B., Serdaroglu P., and Akman-Demir G. Clinical characteristics and course of spinal cord involvement in Behçet's disease. Eur J Neurol 14 (2007) 729-737
91. Moskau S., Urbach H., Hartmann A., and Schmidt S. Multifocal myelitis in Behçet's disease. Neurology 60 (2003) 517
92. Calgüneri M., Onat A.M., Oztürk M.A., et al. Transverse myelitis in a patient with Behçet's disease: favourable outcome with a combination of interferon-alpha. Clin Rheumatol 24 (2005) 64-66
93. Miller D.H., Ormerod I.E., Gibson A., duBoulay E.P., Rudge P., and McDonald W.I. MR brain scanning in patients with vasculitis: differentiation from multiple sclerosis. Neuroradiology 29 (1987) 226-231
94. Grana J., de la Fuente R., Freire M., et al. Lack of finding in MRI and evoked potentials to detect CNS lesions in Behçet's disease. In: Wechsler B., and Godeau P. (Eds). Behçet's disease (1993), Elsevier, Amsterdam 467-470
95. Shimojo S., Yamamoto N., Matsuda T., and Yukinari T. Asymptomatic neuro-Behçet's disease. J Neuroimaging 8 (1998) 59-60
96. Tunç T., Ortapamuk H., Naldöken S., et al. Subclinical neurological involvement in Behçet's disease. Neurol India 54 (2006) 408-411
97. Anlar O., Akdeniz N., Tombul T., Calka O., and Bilgili S.G. Visual evoked potential findings in Behçet's disease without neurological manifestations. Int J Neurosci 116 (2006) 281-287
98. Kececi H. Behçet's disease without neurological manifestations. Tohoku J Exp Med 207 (2005) 1
99. Ozisik H.I., Karlidag R., Hazneci E., Kizkin S., and Ozcan C. Cognitive event-related potential and neuropsychological findings in Behçet's disease without neurological manifestations. Tohoku J Exp Med 206 (2005) 15-22
100. Yesilot N., Shehu M., Oktem-Tanor O., Serdaroglu P., and Akman-Demir G. Silent neurological involvement in Behçet's disease. Clin Exp Rheumatol 24 suppl 42 (2006) S65-S70
101. Masheter H.C. Behçet's syndrome complicated by intracranial thrombophlebitis. Proc R Soc Med 52 (1959) 1039-1040
102. Fadli M.E., and Youssef M.M. Neuro-Behçet syndrome in the United Arab Republic. Eur Neurol 9 (1973) 76-89
103. Bashir R., Al-Kawi M.Z., Jinkins J.R., Al Jaberi M., and Chavis P. Neuroimaging features of Behçet's disease. Ann Saudi Med 9 (1989) 11-15
104. Al-Dalaan A.N., Al-Balaa S.R., El-Ramahi K., et al. Behçet disease in Saudi Arabia. J Rheumatol 21 (1994) 658-661
105. Ozoran K., Dugun N., Gurler, Tutkak H., and Tokgoz G. Plasma von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor and anti-thrombin III levels in Behçet's disease. Scand J Rheumatol 24 (1995) 376-382
106. Chambers J.C., Haskard D.O., and Kooner J.S. Vascular endothelial function and oxidative stress mechanisms in patients with Behçet's syndrome. J Am Coll Cardiol 37 (2001) 517-520
107. Kayikcioglu M., Aksu K., Hasdemir C., et al. Endothelial functions in Behçet's disease. Rheumatol Int 26 (2006) 304-308
108. Yalcindag F.N., Batioglu F., Ozdemir O., Cansizoglu E., Egin Y., and Akar N. Soluble endothelial protein C receptor levels in Behçet patients with and without ocular involvement. Graefes Arch Clin Exp Ophthalmol 246 (2008) 1603-1608
109. Kansu T., Kansu E., Zileli T., and Kirkali P. Neuro-ophthalmologic manifestations of Behçet's disease. Neuroophthalmology 2 (1991) 7-11
110. Yesilot N., Celiktas S., Mutlu M., et al. Cerebral venous and dural sinus thrombosis associated with Behçet's disease. Clin Exp Rheumatol 24 suppl 42 (2006) S30
111. Bousser M.G., and Ferro J.M. Cerebral venous thrombosis: an update. Lancet Neurol 6 (2007) 162-170
112. Pamir M.N., Kansu T., Erbiengi A., and Zileli T. Papilloedema in Behçet's syndrome. Arch Neurol 38 (1981) 643-645
113. Demir G.A., Bahar S., Baykan-Kurt B., Gurvit I.H., and Serdaroglu P. Intracranial hypertension in Behçet's disease. Eur J Neurol 3 (1996) 66-70
114. Nakasu S., Kaneko M., and Matsuda M. Cerebral aneurysms associated with Behçet's disease: a case report. J Neurol Neurosurg Psychiatry 70 (2001) 682-684
115. Kaku Y., Hamada J.I., Kuroda J.I., Kai Y., Morioka M., and Kuratsu J.I. Multiple peripheral middle cerebral artery aneurysms associated with Behçet's disease. Acta Neurochir (Wien) 149 (2007) 823-827
116. Pannone A., Lucchetti G., Stazi G., et al. Internal carotid artery dissection in a patient with Behçet's syndrome. Ann Vasc Surg 12 (1998) 463-467
117. Bouarhroum A., Sedki N., Bouziane Z., et al. Extracranial carotid aneurysm in Behçet disease: report of two new cases. J Vasc Surg 43 (2006) 627-630
118. Ohshima T., Miyachi S., Hattori K., et al. A case of giant common carotid artery aneurysm associated with vascular Behçet disease: successfully treated with a covered stent. Surg Neurol 69 (2008) 297-301
119. Bahar S., Coban O., Gürvit I.H., Akman-Demir G., and Gökyiǧit A. Spontaneous dissection of the extracranial vertebral artery with spinal subarachnoid haemorrhage in a patient with Behçet's disease. Neuroradiology 35 (1993) 352-354
120. Gürer O., Yapici F., Enç Y., Cinar B., and Ozler A. Spontaneous pseudoaneurysm of the vertebral artery in Behçet's disease. Ann Vasc Surg 19 (2005) 280-283
121. Taner E., Coşar B., Burhanoǧlu S., Calikoǧlu E., Onder M., and Arikan Z. Depression and anxiety in patients with Behçet's disease compared with that in patients with psoriasis. Int J Dermatol 46 (2007) 1118-1124
122. Kawakita H., Nishimura M., Satoh Y., and Shibata N. Neurological aspects of Behçet's disease. A case report and clinico-pathological review of the literature in Japan. J Neurol Sci 5 (1967) 417-439
123. Yamada M., Kashiwamura K., Nakamura Y., Ota T., and Nakamura K. On psychiatric symptoms of neuro-Behçet's syndrome. Folia Psychiatr Neurol Jpn 32 (1978) 191-197
124. Epstein R.S., Cummings N.A., Sherwood E.B., and Bergsma D.R. Psychiatric aspects of Behçet's syndrome. J Psychosom Res 14 (1970) 161-172
125. Monastero R., Camarda C., Pipia C., et al. Cognitive impairment in Behçet's disease patients without overt neurological involvement. J Neurol Sci 220 (2004) 99-104
126. Gökçay F., Celebisoy N., Kisabay A., Kumral E., and Akyürekli O. P300 and neuropsychological evaluation in Behçet's disease with and without neurological manifestations. J Neurol 251 (2004) 676-679
127. Oktem-Tanör O., Baykan-Kurt B., Gürvit I.H., Akman-Demir G., and Serdaroǧlu P. Neuropsychological follow-up of 12 patients with neuro-Behçet disease. J Neurol 246 (1999) 113-119
128. Borhani-Haghighi A., Aflaki E., and Ketabchi L. The prevalence and characteristics of different types of headache in patients with Behçet's disease, a case-control study. Headache 48 (2008) 424-429
129. Kidd D. The prevalence of headache in Behçet's syndrome. Rheumatology (Oxford) 45 (2006) 621-623
130. Aykutlu E., Baykan B., Akman-Demir G., Topcular B., and Ertas M. Headache in Behçet's disease. Cephalalgia 26 (2006) 180-186
131. Saip S., Siva A., Altintas A., et al. Headache in Behçet's syndrome. Headache 45 (2005) 911-919
132. Monastero R., Mannino M., Lopez G., et al. Prevalence of headache in patients with Behçet's disease without overt neurological involvement. Cephalalgia 23 (2003) 105-108
133. Namer I.J., Karabudak R., Zileli T., Ruacan S., Küçükali T., and Kansu E. Peripheral nervous system involvement in Behçet's disease. Case report and review of the literature. Eur Neurol 26 (1987) 235-240
134. Walker L.J., Swallow M.W., and Mirakhur M. Behçet's disease presenting with mononeuritis multiplex. Ulster Med J 59 (1990) 206-210
135. Wakayama Y., Takayanagi T., Iida M., Matsuoka Y., and Sobue I. Biopsy study of the peripheral nerves in neuro-Behçet's syndrome. Rinsho Shinkeigaku 14 (1974) 519-525
136. Aksoyek S., Aytemir K., Ozer N., Ozcebe O., and Oto A. Assessment of autonomic nervous system function in patients with Behçet's disease by spectral analysis of heart rate variability. J Auton Nerv Syst 77 (1999) 190-194
137. Atasoy H.T., Tunc T.O., Unal A.E., et al. Peripheral nervous system involvement in patients with Behçet disease. Neurologist 13 (2007) 225-230
138. Uziel Y., Lazarov A., Cordoba M., and Wolach B. Paediatric Behçet's disease manifested as recurrent myositis: from an incomplete to a full-blown form. Eur J Paediatr 159 (2000) 507-508
139. Sarui H., Maruyama T., Ito I., et al. Necrotizing myositis in Behçet's disease: characteristic features on magnetic resonance imaging and a review of the literature. Ann Rheum Dis 61 (2002) 751-752
140. Koné-Paut I., Yurdakul S., Bahabri S.A., et al. Clinical features of Behçet's disease in children: an international collaborative study of 86 cases. J Pediatr 132 (1998) 721-725
141. Uziel Y., Brik R., Padeh S., et al. Juvenile Behçet's disease in Israel. The Pediatric Rheumatology Study Group of Israel. Clin Exp Rheumatol 16 (1998) 502-505
142. Eldem B., Onur C., and Ozen S. Clinical features of pediatric Behçet's disease. J Pediatr Ophthalmol Strabismus 35 (1998) 159-161
143. Allali F., Benomar A., Karim A., et al. Behçet's disease in Moroccan children: a report of 12 cases. Scand J Rheumatol 33 (2004) 362-363
144. Piptone N., Olivieri I., Padula A., et al. Infliximab for the treatment of neuro-Behçet's disease: a case series and review of the literature. Arthritis Rheum 59 (2008) 285-290
145. Kikuchi H., Aramaki K., and Hirohata S. Low dose MTX for progressive neuro-Behçet's disease. A follow-up study for 4 years. Adv Exp Med Biol 528 (2003) 575-578
146. Hatemi G., Silman A., Bang D., et al. Management of Behçet's disease: a systematic literature review for the EULAR evidence based recommendations for the management of Behçet's disease. Ann Rheum Dis 67 (2008) 1656-1662
147. Serkova N.J., Christians U., and Benet L.Z. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv 4 (2004) 97-107
148. Kotake S., Higashi K., Yoshikawa K., Sasamoto Y., Okamoto T., and Matsuda H. Central nervous system symptoms in patients with Behçet disease receiving cyclosporine therapy. Ophthalmology 106 (1999) 586-589
149. Kato Y., Numaga J., Kato S., Kaburaki T., Kawashima H., and Fujino Y. Central nervous system symptoms in a population of Behçet's disease patients with refractory uveitis treated with cyclosporine A. Clin Exp Ophthalmol 29 (2001) 335-336
150. Kötter I., Günaydin I., Batra M., et al. CNS involvement occurs more frequently in patients with Behçet's disease under cyclosporin A (CSA) than under other medications: results of a retrospective analysis of 117 cases. Clin Rheumatol 25 (2006) 482-486