Broad spectrum antiviral fractions from the lichen Ramalina farinacea (L.) Ach.

Chemotherapy

Volumn 55, Issue 2, 2009, Pages 119-126

  Esimone, C O ^a,c   Grunwald, T ^a   Nworu, C S ^a,c   Kuate, S ^a   Proksch, P ^b   Uberla K ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Adenoviruses; Herpes simplex virus 1; Human immunodeficiency virus 1; Lichen; Medicinal plants; Ramalina farinacea; Respiratory syncytial virus

Indexed keywords

ACETIC ACID ETHYL ESTER; BETA GALACTOSIDASE; BROXURIDINE; ET 4; GLYCINE DEHYDROGENASE (DECARBOXYLATING); HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; LENTIVIRUS VECTOR; MONOCLONAL ANTIBODY; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ANTIVIRAL ACTIVITY; ARTICLE; BIOASSAY; CELL LINE; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA VIRUS; ENZYME ACTIVITY; ENZYME INHIBITION; FRACTIONATION; HERPES SIMPLEX VIRUS 1; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IMMUNOFLUORESCENCE; LICHEN; MICROTITER PLATE ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RNA VIRUS; SCREENING; VIRUS REPLICATION;

ANTIVIRAL AGENTS; HERPESVIRUS 1, HUMAN; HIV-1; LICHENS; RESPIRATORY SYNCYTIAL VIRUSES; VIRUS REPLICATION;

EID: 58249132565     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000194974     Document Type: Article

References (29)

1. Jassim SA, Naji MA: Novel antiviral agents: a medicinal plant perspective. J Appl Microbiol 2003;95:412-427.
2. Cowan MM: Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12:564-582.
3. Vlietinck AJ, Vanden BDA: Can ethnopharmacology contribute to the development of antiviral drugs? J Ethnopharmacol 1991;32:141-153.
4. Williams JE: Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Altern Med Rev 2001;6:567-579.
5. De Clercq E: Antiviral therapy for human immunodeficiency virus infections. Clin Microbiol Rev 1995;8:200-239.
6. Cheng H-Y, Huang H-H, Yang C-M, Lin L-T, Lin C-C: The in vitro anti-herpes simplex virus type-1 and type-2 activity of Long Dan Xie Gan Tan, a prescription of traditional Chinese medicine. Chemotherapy 2008;54:77-83. DOI:10.1159/000119705.
7. Esimone CO, Omobowajo OR, Sowemimo AA, Proksch P: Single-cycle vector-based antiviral screening assays for high throughput evaluation of potential anti-HIV medicinal plants: a pilot study on some Nigerian herbs. Rec Prog Med Plant Res 2007;19:49-60.
8. De Clercq E: Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Med Res Rev 2000;20:323-349.
9. Aiken C, Chen CH: Betulinic acid derivatives as HIV-1 antivirals. Trends Mol Med 2005;11:31-36.
10. Asres K, Bucar F, Kartnig T, Witvrouw M, Pannecouque C, De Clercq E: Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants. Phytother Res 2001;15:62-69.
11. Chattopadhyay D, Arunachalam G, Mandal AB, Bhattacharya SK: Dose-dependent therapeutic antiinfectives from ethnomedicines of Bay Islands. Chemotherapy 2006;52:151-157. DOI:10.1159/000092859.
12. Li Z, Li L, Sun Y, Li J: Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L. ethanol extract. Chemotherapy 2007;53:320-326 DOI:10.1159/000107690.
13. Esimone CO, Grunwald T, Wildner O, Nchinda G, Tippler B, Proksch P, Ueberla K: In vitro pharmacodynamic evaluation of antiviral medicinal plants using a vector-based assay technique. J Appl Microbiol 2005;99:1346-1355.
14. Esimone CO, Adikwu MU: Susceptibility of some clinical isolates of Staphylococcus aureus to bioactive column fractions from the lichen Ramalina farinacea (L) Ach. Phytother Res 2002;16:494-496.
15. Esimone CO, Adikwu MU: Antimicrobial activity and cytotoxicity of Ramalina farinacea. Fitoterapia 70;1999:428-431.
16. Esimone CO, Adikwu MU, Ebi GC, Anaga A, Njoku C: Physicochemical evaluations and bioactive properties of column fractions from the lichen Ramalina farinacea (L) Ach. Boll Chim Farm 1999;138:19-25.
17. Esimone CO, Nwodo NJ, Iroha, IR and Ogbuefi NR: Antifungal screening of the methanolic extract of the Lichen Ramalina farinacea (L) Ach. Afric J Pharm Res Dev 2006;2:1-6.
18. Neamati N, Hong H, Mazumder A., Wang S, Sunder S, Nicklaus MC, Milne GW, Proksa B, Pommier Y: Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching. J Med Chem 1997;40:942-951.
19. Pengsuparp T, Cai L, Constant H, Fong HH, Lin LZ, Kinghorn AD, Pezzuto JM, Cordell GA, Ingolfsdottir K, Wagner H, Hughes SH: Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase. J Nat Prod 1995;58:1024-1031.
20. Cohen PA, Hudson JB, Towers GH: Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens. Experientia 1996;52:180-183.
21. Schnell T, Foley P, Wirth M, Munch J, Uberla, T: Development of a self-inactivating, minimal lentivirus vector based on simian immunodeficiency virus. Hum Gene Ther 2000;11:439-447.
22. Chackerian B, Haigwood NL, Overbaugh J: Characterization of a CD4-expressing macaque cell line that can detect virus after a single replication cycle and can be infected by diverse simian immunodeficiency virus isolates. Virology 1995:213:386-394.
23. Esimone CO, Omobowajo OR, Amadi C, Adikwu MU, Edrada R, Proksch P, Nabi G. Antiviral potentials of Nigerian Aframomum melegueta Roscoe and Piper guineense Schum. and Thonn. Nig J Nat Prod Med 2006;10:51-54.
24. Steinstraesser L, Tippler B, Mertens J, Lamme E, Homann, H, Lehnhardt M, Wildner O, Steinau H, Uberla K: Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides. Retrovirol 2005;2:2. DOI:10.1186/1742-4690-2-2.
25. Cianci C, Yu K, Combrink K, Sin N, Pearce B, Wang A, Civiello R, Voss S, Luo G, Kadow K, Genovesi EV, Venables B, Gulgeze H, Trehan A, James J, Lamb L, Medina I, Roach J, Yang Z, Zadjura L, Colonno R, Clark J, Meanwell N, Krystal M: Orally active fusion inhibitor of respiratory syncytial virus. Antimicrob Agents Chemother 2004;48:413-422.
26. Huntley CC, Weiss WJ, Gazumyan A, Buklan A, Feld B, Hu W, Jones TR, Murphy T, Nikitenko AA, O'Hara B, Prince G, Quartuccio S, Raifeld YE, Wyde P, O'Connell JF: RFI-641, a potent respiratory syncytial virus inhibitor. Antimicrob Agents Chemother 2002;46:841-847.
27. Robertson SE, Roca A, Alonso P, Simoes EAF, Kartasasmita CB, Olaleye DO, Odaibo GN, Collinson M, Venter M, Zhu Y, Wright P: Respiratory syncytial virus infection: denominator-based studies in Indonesia, Mozambique, Nigeria and South Africa. Bull World Health Org 2004;82:914-922.
28. Selwyn BJ: The epidemiology of acute respiratory tract infections in young children: comparison of findings from several developed countries. Rev Infect Dis 1990;12:S870-S888.
29. World Health Organization: Traditional Medicine and Modern Health Care: Progress Report by the Directorate General. Document No. A44/1022. Geneva, WHO, 1991.